(Q40461705)

English

Substrate specificity of recombinant dengue 2 virus NS2B-NS3 protease: influence of natural and unnatural basic amino acids on hydrolysis of synthetic fluorescent substrates.

scientific article published on 16 November 2006

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scholarly article

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Europe PubMed Central

PubMed publication ID

20 September 2017

Substrate specificity of recombinant dengue 2 virus NS2B-NS3 protease: influence of natural and unnatural basic amino acids on hydrolysis of synthetic fluorescent substrates. (English)

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Europe PubMed Central

PubMed publication ID

20 September 2017

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dengue NS2B-NS3 protease

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based on heuristic

inferred from abstract

David P. Fairlie

11

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20 September 2017

author name string

Gouvea IE

1

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Europe PubMed Central

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20 September 2017

Izidoro MA

2

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Europe PubMed Central

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20 September 2017

Judice WA

3

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Europe PubMed Central

PubMed publication ID

20 September 2017

Cezari MH

4

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Europe PubMed Central

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20 September 2017

Caliendo G

5

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Europe PubMed Central

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20 September 2017

Santagada V

6

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Europe PubMed Central

PubMed publication ID

20 September 2017

dos Santos CN

7

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Europe PubMed Central

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20 September 2017

Queiroz MH

8

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20 September 2017

Juliano MA

9

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20 September 2017

Young PR

10

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20 September 2017

Juliano L

12

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20 September 2017

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publication date

16 November 2006

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20 September 2017

number of pages

10

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Archives of Biochemistry and Biophysics

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20 September 2017

457

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20 September 2017

2

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20 September 2017

187-196

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20 September 2017

Haematology in dengue and dengue haemorrhagic fever

1 reference

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Cleavage of the dengue virus polyprotein at the NS3/NS4A and NS4B/NS5 junctions is mediated by viral protease NS2B-NS3, whereas NS4A/NS4B may be processed by a cellular protease

1 reference

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4 November 2022

Probing the substrate specificity of the dengue virus type 2 NS3 serine protease by using internally quenched fluorescent peptides

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4 November 2022

Processing and localization of Dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5

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Competitive inhibition of the dengue virus NS3 serine protease by synthetic peptides representing polyprotein cleavage sites

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Alterations of pr-M cleavage and virus export in pr-M junction chimeric dengue viruses

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Polyarginines are potent furin inhibitors

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4 November 2022

Purified NS2B/NS3 serine protease of dengue virus type 2 exhibits cofactor NS2B dependence for cleavage of substrates with dibasic amino acids in vitro

1 reference

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4 November 2022

Dengue viral infections; pathogenesis and epidemiology

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4 November 2022

Cotranslational membrane insertion of the serine proteinase precursor NS2B-NS3(Pro) of dengue virus type 2 is required for efficient in vitro processing and is mediated through the hydrophobic regions of NS2B.

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4 November 2022

Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries.

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4 November 2022

Proteases universally recognize beta strands in their active sites

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Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors.

1 reference

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4 November 2022

Steady-state cleavage kinetics for dengue virus type 2 ns2b-ns3(pro) serine protease with synthetic peptides

1 reference

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4 November 2022

In vitro determination of dengue virus type 2 NS2B-NS3 protease activity with fluorescent peptide substrates

1 reference

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4 November 2022

Identification and characterization of nonsubstrate based inhibitors of the essential dengue and West Nile virus proteases

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4 November 2022

Crystal structure of Dengue virus NS3 protease in complex with a Bowman-Birk inhibitor: implications for flaviviral polyprotein processing and drug design

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4 November 2022

Homology model of the dengue 2 virus NS3 protease: putative interactions with both substrate and NS2B cofactor.

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4 November 2022

Enhancement of hepatitis C virus NS3 proteinase activity by association with NS4A-specific synthetic peptides: identification of sequence and critical residues of NS4A for the cofactor activity

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4 November 2022

Use of a fluorescence plate reader for measuring kinetic parameters with inner filter effect correction

1 reference

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4 November 2022

Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase

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Conformation of angiotensin II in aqueous solution. Titration of several peptide analogs and homologs

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alpha1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: application as an antipathogenic agent

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4 November 2022

Substrate specificity of human kallikrein 6: salt and glycosaminoglycan activation effects

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4 November 2022

Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein

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4 November 2022

Synthesis and hydrolysis by cathepsin B of fluorogenic substrates with the general structure benzoyl-X-ARG-MCA containing non-natural basic amino acids at position X.

1 reference

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4 November 2022

Internally quenched fluorogenic protease substrates: Solid-phase synthesis and fluorescence spectroscopy of peptides containing ortho-aminobenzoyl/dinitrophenyl groups as donor-acceptor pairs

1 reference

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4 November 2022

Identifiers

10.1016/J.ABB.2006.11.005

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

ResearchGate publication ID

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