(Q40499239)

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Sustained phenotypic correction of hemophilia a mice following oncoretroviral-mediated expression of a bioengineered human factor VIII gene in long-term hematopoietic repopulating cells

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Europe PubMed Central

21 September 2017

Sustained phenotypic correction of hemophilia a mice following oncoretroviral-mediated expression of a bioengineered human factor VIII gene in long-term hematopoietic repopulating cells (English)

1 reference

Europe PubMed Central

21 September 2017

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Coagulation factor VIII

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Robert G Hawley

5

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author name string

Morvarid Moayeri

1

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Europe PubMed Central

21 September 2017

Ali Ramezani

2

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Europe PubMed Central

21 September 2017

Richard A Morgan

3

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Europe PubMed Central

21 September 2017

Teresa S Hawley

4

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Europe PubMed Central

21 September 2017

publication date

1 November 2004

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Europe PubMed Central

21 September 2017

Molecular Therapy

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Europe PubMed Central

21 September 2017

10

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Europe PubMed Central

21 September 2017

5

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Europe PubMed Central

21 September 2017

892-902

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Europe PubMed Central

21 September 2017

Development of improved factor VIII molecules and new gene transfer approaches for hemophilia A.

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7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.08.006

7 January 2021

Haemophilias A and B.

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7 January 2021

Gene transfer as an approach to treating hemophilia

1 reference

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Progress toward vector design for hematopoietic stem cell gene therapy

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Hematopoietic stem cell gene therapy: towards clinically significant gene transfer efficiency

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Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy

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Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning

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Genetic induction of immune tolerance to human clotting factor VIII in a mouse model for hemophilia A

1 reference

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Thrombopoietic potential and serial repopulating ability of murine hematopoietic stem cells constitutively expressing interleukin 11.

1 reference

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Development and analysis of retroviral vectors expressing human factor VIII as a potential gene therapy for hemophilia A.

1 reference

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7 January 2021

Gene therapy for hemophilia A: production of therapeutic levels of human factor VIII in vivo in mice

1 reference

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Mutagenesis of a potential immunoglobulin-binding protein-binding site enhances secretion of coagulation factor VIII

1 reference

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Efficient production of human FVIII in hemophilic mice using lentiviral vectors

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7 January 2021

Generation and characterization of human hematopoietic cell lines expressing factor VIII.

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7 January 2021

Recombinant factor VIII expression in hematopoietic cells following lentiviral transduction.

1 reference

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Simplified retroviral vector gcsap with murine stem cell virus long terminal repeat allows high and continued expression of enhanced green fluorescent protein by human hematopoietic progenitors engrafted in nonobese diabetic/severe combined immunode

1 reference

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7 January 2021

Long-term persistence of human bone marrow stromal cells transduced with factor VIII-retroviral vectors and transient production of therapeutic levels of human factor VIII in nonmyeloablated immunodeficient mice

1 reference

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Bone marrow mesenchymal cells for haemophilia A gene therapy using retroviral vectors with modified long-terminal repeats

1 reference

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Preselection of retrovirally transduced bone marrow avoids subsequent stem cell gene silencing and age-dependent extinction of expression of human beta-globin in engrafted mice.

1 reference

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7 January 2021

Bioengineering of coagulation factor VIII for improved secretion

1 reference

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7 January 2021

Integrative molecular and developmental biology of adult stem cells

1 reference

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7 January 2021

Bone marrow-derived mesenchymal stem cells remain host-derived despite successful hematopoietic engraftment after allogeneic transplantation in patients with lysosomal and peroxisomal storage diseases

1 reference

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7 January 2021

Isolation of mouse marrow mesenchymal progenitors by a novel and reliable method

1 reference

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7 January 2021

In vivo persistence of retrovirally transduced murine long-term repopulating cells is not limited by expression of foreign gene products in the fully or minimally myeloablated setting

1 reference

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7 January 2021

Myeloablation enhances engraftment of transduced murine hematopoietic cells, but does not influence long-term expression of the transgene

1 reference

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Engraftment of retroviral EGFP-transduced bone marrow in mice prevents rejection of EGFP-transgenic skin grafts

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Introduction of a xenogeneic gene via hematopoietic stem cells leads to specific tolerance in a rhesus monkey model

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Induction of transgene-specific immunological tolerance in myeloablated nonhuman primates using lentivirally transduced CD34+ progenitor cells

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LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

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Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiency

1 reference

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Handicapped retroviral vectors efficiently transduce foreign genes into hematopoietic stem cells

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Performance- and safety-enhanced lentiviral vectors containing the human interferon-beta scaffold attachment region and the chicken beta-globin insulator

1 reference

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Retroviral vectors for production of interleukin-12 in the bone marrow to induce a graft-versus-leukemia effect

1 reference

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7 January 2021

Versatile retrovirus vector systems for regulated gene expression in vitro and in vivo.

1 reference

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Comparative analysis of retroviral vector expression in mouse embryonal carcinoma cells

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Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1 reference

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Increased frequency of both total and specific monoclonal antibody producing hybridomas using a fusion partner that constitutively expresses recombinant IL-6.

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Sustained correction of bleeding disorder in hemophilia B mice by gene therapy

1 reference

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Lentiviral vectors for enhanced gene expression in human hematopoietic cells

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DNA rearrangements in human follicular lymphoma can involve the 5' or the 3' region of the bcl-2 gene

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10.1016/J.YMTHE.2004.08.006

1 reference

Europe PubMed Central

21 September 2017

1 reference

Europe PubMed Central

21 September 2017

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