(Q40499246)

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Enhanced in vivo selection of bone marrow cells by retroviral-mediated coexpression of mutant O6-methylguanine-DNA-methyltransferase and HOXB4.

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scholarly article

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Europe PubMed Central

PubMed publication ID

21 September 2017

Enhanced in vivo selection of bone marrow cells by retroviral-mediated coexpression of mutant O6-methylguanine-DNA-methyltransferase and HOXB4. (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Richard Humphries

4

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21 September 2017

author name string

Michael D Milsom

1

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21 September 2017

Lorna B Woolford

2

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21 September 2017

Geoffrey P Margison

3

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21 September 2017

Leslie J Fairbairn

5

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21 September 2017

publication date

1 November 2004

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21 September 2017

Molecular Therapy

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21 September 2017

10

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21 September 2017

5

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21 September 2017

862-873

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21 September 2017

Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy

1 reference

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Gene therapy of severe combined immunodeficiencies

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Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

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Gene therapy of X-linked severe combined immunodeficiency

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Dose finding with retroviral vectors: correlation of retroviral vector copy numbers in single cells with gene transfer efficiency in a cell population

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Genetic chemoprotection with mutant O6-alkylguanine-DNA-alkyltransferases

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Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents

1 reference

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Hematoprotection and enrichment of transduced cells in vivo after gene transfer of MGMT(P140K) into hematopoietic stem cells

1 reference

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Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo

1 reference

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HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation.

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HOXB4-induced expansion of adult hematopoietic stem cells ex vivo.

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Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells

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The competitive nature of HOXB4-transduced HSC is limited by PBX1: the generation of ultra-competitive stem cells retaining full differentiation potential

1 reference

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Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein

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Reduction in hematopoietic stem cell numbers with in vivo drug selection can be partially abrogated by HOXB4 gene expression

1 reference

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LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

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Enforced adenoviral vector-mediated expression of HOXB4 in human umbilical cord blood CD34+ cells promotes myeloid differentiation but not proliferation

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High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation

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Improved post-transcriptional processing of an MDR1 retrovirus elevates expression of multidrug resistance in primary human hematopoietic cells

1 reference

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Chemoprotective gene transfer II: multilineage in vivo protection of haemopoiesis against the effects of an antitumour agent by expression of a mutant human O6-alkylguanine-DNA alkyltransferase.

1 reference

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Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

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10.1016/J.YMTHE.2004.07.019

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

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