(Q40499871)

21 September 2017

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title

Topoisomerase inhibitors. A review of their therapeutic potential in cancer (English)

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21 September 2017

B K Sinha

1

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21 September 2017

publication date

1 January 1995

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21 September 2017

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21 September 2017

volume

49

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21 September 2017

issue

1

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21 September 2017

page(s)

11-19

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CPT-11: a new derivative of camptothecin for the treatment of refractory or relapsed small-cell lung cancer

21 September 2017

cites work

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12 December 2020

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

1 reference

12 December 2020

Effect of VP-16-213 on the intracellular degradation of DNA in HeLa cells

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12 December 2020

Phase II study of 9-hydroxy-2N-methylellipticinium acetate

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12 December 2020

Phosphorylation of mammalian DNA topoisomerase I and activation by protein kinase C.

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12 December 2020

Mitoxantrone affects topoisomerase activities in human breast cancer cells

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12 December 2020

Relationship of VP-16 to the classical multidrug resistance phenotype

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12 December 2020

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

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12 December 2020

Phase I and pharmacologic study of topotecan: a novel topoisomerase I inhibitor

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12 December 2020

Two mechanisms of adriamycin-DNA interaction in L1210 cells

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12 December 2020

Preliminary pharmacologic and clinical evaluation of camptothecin sodium (NSC-100880).

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12 December 2020

Potentiation of topoisomerase inhibitor-induced DNA strand breakage and cytotoxicity by tumor necrosis factor: enhancement of topoisomerase activity as a mechanism of potentiation.

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12 December 2020

Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II.

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12 December 2020

Structure-activity relations, cytotoxicity and topoisomerase II dependent cleavage induced by pendulum ring analogues of etoposide

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12 December 2020

Comparison of cytotoxicity and DNA breakage activity of congeners of podophyllotoxin including VP16-213 and VM26: a quantitative structure-activity relationship

1 reference

12 December 2020

An early phase II study of CPT-11: a new derivative of camptothecin, for the treatment of leukemia and lymphoma.

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12 December 2020

DNA topoisomerases--enzymes that catalyse the breaking and rejoining of DNA.

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12 December 2020

Interaction of some daunomycin derivatives with deoxyribonucleic acid and their biological activity

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12 December 2020

Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II

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12 December 2020

Iron-dependent hydroxyl radical formation and DNA damage from a novel metabolite of the clinically active antitumor drug VP-16.

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12 December 2020

The current status of camptothecin analogues as antitumor agents

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12 December 2020

Inhibitors of DNA topoisomerases

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12 December 2020

Relationship of adriamycin concentrations to the DNA lesions induced in hypoxic and euoxic L1210 cells

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12 December 2020

Qualitative and quantitative aspects of intercalator-induced DNA strand breaks

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12 December 2020

Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide

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12 December 2020

Antitumor effect of CPT-11, a new derivative of camptothecin, against pleiotropic drug-resistant tumors in vitro and in vivo

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12 December 2020

DNA topoisomerases as targets for chemotherapy

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12 December 2020

Free radicals in anticancer drug pharmacology

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12 December 2020

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11

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12 December 2020

Peroxidase-catalyzed metabolism of etoposide (VP-16-213) and covalent binding of reactive intermediates to cellular macromolecules

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12 December 2020

Resistance to multiple chemotherapeutic agents in human cancer cells

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12 December 2020

Characteristics of the binding of the anticancer agents mitoxantrone and ametantrone and related structures to deoxyribonucleic acids

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12 December 2020

Characterization of free radicals produced during oxidation of etoposide (VP-16) and its catechol and quinone derivatives. An ESR Study

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12 December 2020

Effect of P-glycoprotein expression on the accumulation and cytotoxicity of topotecan (SK&F 104864), a new camptothecin analogue.

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12 December 2020

Mechanisms of resistance to drugs that inhibit DNA topoisomerases

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12 December 2020

P-glycoprotein-independent mechanism of resistance to VP-16 in multidrug-resistant tumor cell lines: pharmacokinetic and photoaffinity labeling studies

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12 December 2020

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

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12 December 2020

DNA strand breaks produced by etoposide (VP-16,213) in sensitive and resistant human breast tumor cells: implications for the mechanism of action

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12 December 2020

Cleavage of DNA by mammalian DNA topoisomerase II

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12 December 2020

Proliferation- and cell cycle-dependent differences in expression of the 170 kilodalton and 180 kilodalton forms of topoisomerase II in NIH-3T3 cells

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12 December 2020

Multidrug resistance-associated protein gene overexpression and reduced drug sensitivity of topoisomerase II in a human breast carcinoma MCF7 cell line selected for etoposide resistance

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12 December 2020

Copper ion-dependent oxy-radical mediated DNA damage from dihydroxy derivative of etoposide

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12 December 2020

Resistance of human leukemic and normal lymphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II

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12 December 2020

Protein-associated DNA breaks in cells treated with adriamycin or ellipticine

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12 December 2020

Free radicals and anticancer drug resistance: oxygen free radicals in the mechanisms of drug cytotoxicity and resistance by certain tumors

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12 December 2020

Tyrosinase-induced free radical formation from VP-16,213: relationship to cytotoxicity

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12 December 2020

10.2165/00003495-199549010-00002

Identifiers

DOI

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Dimensions Publication ID

21 September 2017

1037019886

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