(Q40517227)

21 September 2017

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title

Problems of delivery of monoclonal antibodies. Pharmaceutical and pharmacokinetic solutions (English)

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21 September 2017

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R M Reilly

1

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21 September 2017

J Sandhu

2

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21 September 2017

T M Alvarez-Diez

3

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21 September 2017

S Gallinger

4

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21 September 2017

J Kirsh

5

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21 September 2017

H Stern

6

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21 September 2017

1 February 1995

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Clinical Pharmacokinetics

21 September 2017

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21 September 2017

28

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21 September 2017

2

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21 September 2017

126-142

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https://scigraph.springernature.com/pub.10.2165/00003088-199528020-00004

21 September 2017

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cites work

A new approach to the problem of targeting specific monoclonal antibodies to human tumors using anti-hapten chimeric antibodies

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12 December 2020

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12 December 2020

Therapeutic advantage of high-affinity anticarcinoma radioimmunoconjugates

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12 December 2020

Plasmapheresis in radioimmunotherapy of micrometastases: a mathematical modeling and dosimetrical analysis

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12 December 2020

Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms

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12 December 2020

Exchange of macromolecules between plasma and peritoneal cavity in ascites tumor-bearing, normal, and serotonin-injected mice

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12 December 2020

Three-step monoclonal antibody tumor targeting in carcinoembryonic antigen-positive patients

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12 December 2020

Intratumoral generation of 5-fluorouracil mediated by an antibody-cytosine deaminase conjugate in combination with 5-fluorocytosine

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12 December 2020

Structure of solid tumors and their vasculature: implications for therapy with monoclonal antibodies

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12 December 2020

Colorectal tumors: scintigraphy with In-111 anti-CEA monoclonal antibody and correlation with surgical, histopathologic, and immunohistochemical findings

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12 December 2020

Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier

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12 December 2020

The characteristics of blood-borne radiolabels and the effect of anti-mouse IgG antibodies on localization of radiolabeled monoclonal antibody in cancer patients

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12 December 2020

Regional heterogeneity and complementation in the expression of the tumor-associated glycoprotein 72 epitopes in colorectal cancer

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12 December 2020

Generation and characterization of B72.3 second generation monoclonal antibodies reactive with the tumor-associated glycoprotein 72 antigen

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12 December 2020

Effect of tumor mass and antigenic nature on the biodistribution of labeled monoclonal antibodies in mice

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12 December 2020

Improved detection of hepatic lesions using MoAb B72.3 and a modified 111In labelling technique in patients with recurrent colon cancer

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12 December 2020

Improved radiolabeled monoclonal antibody uptake by lavage of intraperitoneal carcinomatosis in mice

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12 December 2020

A general, extracorporeal immunoadsorption method to increase the tumor-to-normal tissue ratio in radioimmunoimaging and radioimmunotherapy

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12 December 2020

An analysis of monoclonal antibody distribution in microscopic tumor nodules: consequences of a "binding site barrier".

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12 December 2020

Galactosylated antibodies and antibody-enzyme conjugates in antibody-directed enzyme prodrug therapy

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12 December 2020

Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors

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12 December 2020

Development of biologically active peptides based on antibody structure

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12 December 2020

Rapid blood clearance of biotinylated IgG after infusion of avidin

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12 December 2020

Production of murine V-human Cr1 chimeric anti-TAG72 antibody using V region cDNA amplified by PCR.

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12 December 2020

Two-step tumour targetting in ovarian cancer patients using biotinylated monoclonal antibodies and radioactive streptavidin

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12 December 2020

Processing of antibody-radioisotope conjugates after binding to the surface of tumor cells

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12 December 2020

Yttrium-90-labeled monoclonal antibody for therapy: labeling by a new macrocyclic bifunctional chelating agent

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12 December 2020

Disulfide bond-targeted radiolabeling: tumor specificity of a streptavidin-biotinylated monoclonal antibody complex

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12 December 2020

A preliminary pharmacokinetic study of 111In-labeled 260F9 anti-(breast cancer) antibody in patients

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12 December 2020

Quantitative and qualitative aspects of radiolocalization in colon cancer patients of intravenously administered MAb B72.3.

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12 December 2020

Immunogenicity in rabbits and mice of an antibody-chelate conjugate: comparison of (S) and (R) macrocyclic enantiomers and an acyclic chelating agent

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12 December 2020

[34] Expression of functional antibody Fv and Fab fragments in Escherichia coli

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12 December 2020

Reduction by anti-antibody administration of the radiotoxicity associated with 131I-labeled antibody to carcinoembryonic antigen in cancer radioimmunotherapy

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12 December 2020

The effect of tumor CEA content and tumor size on tissue uptake of indium 111-labeled anti-CEA monoclonal antibody

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12 December 2020

Disposition of a murine monoclonal antibody vinca conjugate (KS1/4-DAVLB) in patients with adenocarcinomas

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12 December 2020

Kinetics of interstitially administered monoclonal antibodies for purposes of lymphoscintigraphy

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12 December 2020

B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice

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12 December 2020

Phase I evaluation of an anti-breast carcinoma monoclonal antibody 260F9-recombinant ricin A chain immunoconjugate

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12 December 2020

Comparative dual label study of first and second generation antitumor-associated glycoprotein-72 monoclonal antibodies in colorectal cancer patients

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12 December 2020

A distributed pharmacokinetic model of two-step imaging and treatment protocols: application to streptavidin-conjugated monoclonal antibodies and radiolabeled biotin.

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12 December 2020

Use of Radiolabeled Antibodies to Carcinoembryonic Antigen for the Detection and Localization of Diverse Cancers by External Photoscanning

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12 December 2020

Immunoscintigraphy of tumours using 99Tcm-labelled monoclonal antibodies: a review

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12 December 2020

The stability of 99Tcm directly labelled to an Fab' antibody via stannous ion and mercaptoethanol reduction

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12 December 2020

Metabolism of indium chelates attached to monoclonal antibody: minimal transchelation of indium from benzyl-EDTA chelate in vivo.

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12 December 2020

In vitro stability of EDTA and DTPA immunoconjugates of monoclonal antibody 2G3 labeled with indium-111

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12 December 2020

Replacing the complementarity-determining regions in a human antibody with those from a mouse

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12 December 2020

Tumour localisation with a radioactively labelled reshaped human monoclonal antibody

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12 December 2020

Intraperitoneal radio-localization of tumors pre-targeted by biotinylated monoclonal antibodies.

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12 December 2020

Effect of seven new vasoactive immunoconjugates on the enhancement of monoclonal antibody uptake in tumors

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12 December 2020

Antibody-directed enzyme prodrug therapy

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12 December 2020

Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains

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12 December 2020

Biological activity of human-mouse IgG1, IgG2, IgG3, and IgG4 chimeric monoclonal antibodies with antitumor specificity

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12 December 2020

Chelate radiochemistry: cleavable linkers lead to altered levels of radioactivity in the liver

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12 December 2020

Biotin delivery to brain with a covalent conjugate of avidin and a monoclonal antibody to the transferrin receptor

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12 December 2020

Vascular permeability and interstitial diffusion of macromolecules in the hamster cheek pouch: effects of vasoactive drugs

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12 December 2020

In vitro and in vivo evaluation of streptavidin immunoconjugates of the second generation TAG-72 monoclonal antibody CC49.

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12 December 2020

Reduction of background activities by introduction of a diester linkage between antibody and a chelate in radioimmunodetection of tumor

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12 December 2020

Recombinant Toxins for Cancer Treatment

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12 December 2020

Engineering of antibodies

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12 December 2020

A modeling analysis of monoclonal antibody percolation through tumors: a binding-site barrier.

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12 December 2020

Quantitative analyses of selective radiolabeled monoclonal antibody localization in metastatic lesions of colorectal cancer patients

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12 December 2020

Radioimmunolocalization of human carcinoma xenografts with B72.3 second generation monoclonal antibodies.

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12 December 2020

Functional immunoglobulin M production after transfection of cloned immunoglobulin heavy and light chain genes into lymphoid cells

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12 December 2020

Approaches to radiolabeling of antibodies for diagnosis and therapy of cancer

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12 December 2020

A genetically engineered murine/human chimeric antibody retains specificity for human tumor-associated antigen.

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12 December 2020

Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism

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12 December 2020

The preparation of DTPA-coupled antibodies radiolabeled with metallic radionuclides: an improved method

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12 December 2020

Quantitative analysis of antibody localization in human metastatic colon cancer: a phase I study of monoclonal antibody A33.

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12 December 2020

Specific recognition of antibody-oligonucleotide conjugates by radiolabeled antisense nucleotides: a novel approach for two-step radioimmunotherapy of cancer

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12 December 2020

Peritoneal carcinomatosis: imaging with intraperitoneal injection of I-131-labeled B72.3 monoclonal antibody

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12 December 2020

Transfer of a cloned immunoglobulin light-chain gene to mutant hybridoma cells restores specific antibody production

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12 December 2020

Immunolymphoscintigraphy with 99mTc-labeled monoclonal antibody (BW 431/26) reacting with carcinoembryonic antigen in breast cancer

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12 December 2020

A method for the radiohalogenation of proteins resulting in decreased thyroid uptake of radioiodine

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12 December 2020

Pre-targeted immunoscintigraphy of murine tumors with indium-111-labeled bifunctional haptens

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12 December 2020

Immunoscintigraphy of human colon cancer xenografts in nude mice using a second-generation TAG-72 monoclonal antibody labelled with 99Tcm

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12 December 2020

Radioimmunotherapy of malignancies

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12 December 2020

Production of a mouse-human chimeric monoclonal antibody to CD20 with potent Fc-dependent biologic activity.

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12 December 2020

Production of antibodies in transgenic plants

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12 December 2020

Rhenium-186-labeled chimeric antibody NR-LU-13: pharmacokinetics, biodistribution and immunogenicity relative to murine analog NR-LU-10.

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12 December 2020

Comparative biodistributions of yttrium- and indium-labeled monoclonal antibody B72.3 in athymic mice bearing human colon carcinoma xenografts

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12 December 2020

The treatment of intraperitoneal malignant disease with monoclonal antibody guided 131I radiotherapy

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12 December 2020

Effect of antibody dose on the imaging and biodistribution of indium-111 9.2.27 anti-melanoma monoclonal antibody

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12 December 2020

Immunoscintigraphy with three step monoclonal pretargeting technique in diagnosis of uveal melanoma: preliminary results

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12 December 2020

Differences in biodistribution of indium-111-and iodine-131-labeled B72.3 monoclonal antibodies in patients with colorectal cancer

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12 December 2020

Patient biodistribution of intraperitoneally administered yttrium-90-labeled antibody

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12 December 2020

Renaturation, purification and characterization of recombinant Fab-fragments produced in Escherichia coli

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12 December 2020

Pharmacokinetics of 111In-labeled OC-125 antibody in cancer patients compared with the 19-9 antibody

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12 December 2020

Mechanisms of tissue uptake and metabolism of radiolabeled antibody--role of antigen: antibody complex formation

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12 December 2020

Phase I Study of an Anti-Breast Cancer Immunotoxin by Continuous Infusion: Report of a Targeted Toxic Effect Not Predicted by Animal Studies

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12 December 2020

Development and biologic evaluation of a kit for preformed chelate technetium-99m radiolabeling of an antibody Fab fragment using a diamide dimercaptide chelating agent

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12 December 2020

Intracavitary use of two radiolabeled tumor-associated monoclonal antibodies

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12 December 2020

Antibodies against metal chelates

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12 December 2020

Tumor uptake as a function of tumor mass: a mathematic model

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12 December 2020

Single chain antibody (SCA) encoding genes: one-step construction and expression in eukaryotic cells

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12 December 2020

Monoclonal antibodies as reversible equilibrium carriers of radiopharmaceuticals

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12 December 2020

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12 December 2020

Improved pharmacokinetics and tumor localization of immunotoxins constructed with the Mr 30,000 form of ricin A chain.

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12 December 2020

Assembly of a functional immunoglobulin Fv fragment in Escherichia coli

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12 December 2020

Imaging of tumor in patients with indium-111-labeled biotin and streptavidin-conjugated antibodies: preliminary communication

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12 December 2020

In vitro evaluation of DNA-DNA hybridization as a two-step approach in radioimmunotherapy of cancer

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12 December 2020

Pharmacokinetics in patients of an anti-carcinoembryonic antigen antibody radiolabeled with indium-111 using a novel diethylenetriamine pentaacetic acid chelator

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12 December 2020

Human anti-murine immunoglobulin responses in patients receiving monoclonal antibody therapy

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12 December 2020

Pharmacokinetics of monoclonal immunoglobulin G1, F(ab')2, and Fab' in mice

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12 December 2020

Differences in experimental tumor localization of dual-labeled monoclonal antibody

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12 December 2020

Production of functional chimaeric mouse/human antibody

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12 December 2020

Genetic construction, expression, and characterization of a single chain anti-carcinoma antibody fused to beta-lactamase

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12 December 2020

Mouse/human chimeric monoclonal antibody in man: kinetics and immune response

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12 December 2020

Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure

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12 December 2020

Tumor size: effect on monoclonal antibody uptake in tumor models.

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12 December 2020

Pre-targeted immunodetection in glioma patients: tumour localization and single-photon emission tomography imaging of [99mTc]PnAO-biotin.

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12 December 2020

Continuous cultures of fused cells secreting antibody of predefined specificity

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12 December 2020

Biodistribution of antibodies after intraperitoneal or intravenous injection and effect of carbohydrate modifications

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12 December 2020

Clearance of 131I-labeled murine monoclonal antibody from patients' blood by intravenous human anti-murine immunoglobulin antibody

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12 December 2020

Anti-antibody enhancement of iodine-131 anti-CEA radioimmunodetection in experimental and clinical studies

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12 December 2020

Localization of radioiodine conjugated to the monoclonal antibody HMFG2 in human ovarian carcinoma: assessment of intravenous and intraperitoneal routes of administration

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12 December 2020

Intracellular metabolism of indium-111-DTPA-labeled receptor targeted proteins.

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12 December 2020

Compartmental analysis of the pharmacokinetics of radioiodinated monoclonal antibody B72.3 in colon cancer patients

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12 December 2020

Interposition of different chemical linkages between antibody and 111In-DTPA to accelerate clearance from non-target organs and blood

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12 December 2020

Clinical comparison of radiolocalization of two monoclonal antibodies (mAbs) against the TAG-72 antigen

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12 December 2020

Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies.

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12 December 2020

Biodistribution and histological localization of anti-human colon cancer monoclonal antibody (MAb) 1A3: the influence of administered MAb dose on tumor uptake

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12 December 2020

Endocytosis and intracellular routing of an antibody-ricin A chain conjugate

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12 December 2020

Immunolymphoscintigraphy for the detection of lymph node metastases from breast cancer

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12 December 2020

Improved sarcoma imaging and reduced hepatic activity with indium-111-SCN-Bz-DTPA linked to MoAb 19-24

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12 December 2020

Expression of an antibody Fv fragment in myeloma cells

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12 December 2020

Pharmacokinetics and immune response of 131I-chimeric mouse/human B72.3 (human gamma 4) monoclonal antibody in humans

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12 December 2020

Pharmacokinetics, immune response, and biodistribution of iodine-131-labeled chimeric mouse/human IgG1,k 17-1A monoclonal antibody

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12 December 2020

Pharmacokinetics of an indium-111-labeled monoclonal antibody in cancer patients

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12 December 2020

10.2165/00003088-199528020-00004

Identifiers

DOI

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Dimensions Publication ID

21 September 2017

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