(Q40531131)

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Inhibition of system A-mediated glycine transport in cortical synaptosomes by therapeutic concentrations of clozapine: implications for mechanisms of action

scientific article published on March 2005

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scholarly article

1 reference

Europe PubMed Central

21 September 2017

Inhibition of system A-mediated glycine transport in cortical synaptosomes by therapeutic concentrations of clozapine: implications for mechanisms of action (English)

1 reference

Europe PubMed Central

21 September 2017

author name string

Javitt DC

1

1 reference

Europe PubMed Central

21 September 2017

Duncan L

2

1 reference

Europe PubMed Central

21 September 2017

Balla A

3

1 reference

Europe PubMed Central

21 September 2017

Sershen H

4

1 reference

Europe PubMed Central

21 September 2017

language of work or name

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publication date

1 March 2005

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Europe PubMed Central

21 September 2017

Molecular Psychiatry

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Europe PubMed Central

21 September 2017

10

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Europe PubMed Central

21 September 2017

3

1 reference

Europe PubMed Central

21 September 2017

275-287

1 reference

Europe PubMed Central

21 September 2017

https://scigraph.springernature.com/pub.10.1038/sj.mp.4001552

0 references

Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine

1 reference

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21 January 2018

Structural evaluation of the prefrontal cortex in schizophrenia.

1 reference

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21 January 2018

Effectiveness of second-generation antipsychotics in patients with treatment-resistant schizophrenia: a review and meta-analysis of randomized trials

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A meta-analysis of the efficacy of second-generation antipsychotics

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New generation antipsychotics versus low-potency conventional antipsychotics: a systematic review and meta-analysis

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21 January 2018

The role of serotonin in antipsychotic drug action

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Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors

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21 January 2018

Does fast dissociation from the dopamine d(2) receptor explain the action of atypical antipsychotics?: A new hypothesis

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21 January 2018

Is the time course of clozapine response correlated to the time course of clozapine plasma levels? A one-year prospective study in drug-resistant patients with schizophrenia.

1 reference

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21 January 2018

Recent advances in the phencyclidine model of schizophrenia

1 reference

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21 January 2018

The glutamatergic dysfunction hypothesis for schizophrenia

1 reference

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Bringing order to the glutamate chaos in schizophrenia

1 reference

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Clozapine but not haloperidol antagonizes an MK-801 discriminative stimulus cue.

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Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review

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Reversal of phencyclidine-induced prepulse inhibition deficits by clozapine in monkeys

1 reference

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21 January 2018

Differential effects of clozapine and haloperidol on ketamine-induced brain metabolic activation.

1 reference

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21 January 2018

Enduring cognitive deficits and cortical dopamine dysfunction in monkeys after long-term administration of phencyclidine.

1 reference

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21 January 2018

Clozapine blunts N-methyl-D-aspartate antagonist-induced psychosis: a study with ketamine.

1 reference

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21 January 2018

Modulation of brain and serum glutamatergic concentrations following a switch from conventional neuroleptics to olanzapine

1 reference

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21 January 2018

The expression of glutamate transporter GLT-1 in the rat cerebral cortex is down-regulated by the antipsychotic drug clozapine

1 reference

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21 January 2018

Double-blind, placebo-controlled, crossover trial of D-cycloserine adjuvant therapy for treatment-resistant schizophrenia.

1 reference

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21 January 2018

Placebo-controlled trial of D-cycloserine added to conventional neuroleptics, olanzapine, or risperidone in schizophrenia

1 reference

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21 January 2018

D-Cycloserine added to risperidone in patients with primary negative symptoms of schizophrenia

1 reference

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21 January 2018

D-cycloserine: a ligand for the N-methyl-D-aspartate coupled glycine receptor has partial agonist characteristics

1 reference

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21 January 2018

Cloning and expression of a glycine transporter reveal colocalization with NMDA receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

21 January 2018

High-affinity transport of gamma-aminobutyric acid, glycine, taurine, L-aspartic acid, and L-glutamic acid in synaptosomal (P2) tissue: a kinetic and substrate specificity analysis

1 reference

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21 January 2018

The glycine transporter-1 inhibitors NFPS and Org 24461: a pharmacological study

1 reference

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21 January 2018

Pharmacological assessment of the role of the glycine transporter GlyT-1 in mediating high-affinity glycine uptake by rat cerebral cortex and cerebellum synaptosomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

21 January 2018

Structure, function, and tissue expression pattern of human SN2, a subtype of the amino acid transport system N.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

21 January 2018

Inhibition of glutamine transport depletes glutamate and GABA neurotransmitter pools: further evidence for metabolic compartmentation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

21 January 2018

Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

21 January 2018

Cloning and functional identification of a neuronal glutamine transporter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

21 January 2018

Involvement of transporter recruitment as well as gene expression in the substrate-induced adaptive regulation of amino acid transport system A.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

21 January 2018

Cloning, expression, and localization of a rat brain high-affinity glycine transporter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

21 January 2018

Characterization of glycine release mediated by glycine transporter 1 stably expressed in HEK-293 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

21 January 2018

The glial and the neuronal glycine transporters differ in their reactivity to sulfhydryl reagents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

21 January 2018

Neuronal and glial glycine transporters have different stoichiometries

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

21 January 2018

3Hglycine uptake in rat hippocampus: kinetic analysis and autoradiographic localization

1 reference

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21 January 2018

A novel system A isoform mediating Na+/neutral amino acid cotransport

1 reference

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21 January 2018

Localization and functional relevance of system a neutral amino acid transporters in cultured hippocampal neurons.

1 reference

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21 January 2018

Functional properties and cellular distribution of the system A glutamine transporter SNAT1 support specialized roles in central neurons.

1 reference

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21 January 2018

Antagonism of phencyclidine-induced hyperactivity by glycine in mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

21 January 2018

A.E. Bennett Research Award. Reversal of phencyclidine-induced effects by glycine and glycine transport inhibitors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

21 January 2018

The role of glycineB binding site and glycine transporter (GlyT1) in the regulation of [3H]GABA and [3H]glycine release in the rat brain

1 reference

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21 January 2018

Discovery and SAR of org 24598-a selective glycine uptake inhibitor

1 reference

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21 January 2018

Pharmacology and expression analysis of glycine transporter GlyT1 with [3H]-(N-[3-(4'-fluorophenyl)-3-(4'phenylphenoxy)propyl])sarcosine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

21 January 2018

Modulation of N-methyl-D-aspartate receptor function by glycine transport

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

21 January 2018

Glycine tranporter-1 blockade potentiates NMDA-mediated responses in rat prefrontal cortical neurons in vitro and in vivo

1 reference

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21 January 2018

Schizophrenia: glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

21 January 2018

ATA2 is predominantly expressed as system A at the blood-brain barrier and acts as brain-to-blood efflux transport for L-proline

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

21 January 2018

Clozapine monitoring: plasma or serum levels?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

7 January 2021

based on heuristic

inferred from DOI database lookup

Tissue concentrations of clozapine and its metabolites in the rat

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of MK-801 on clozapine-induced potentiation of excitatory synaptic responses in the perforant path-dentate gyrus pathway in chronically prepared rabbits

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

7 January 2021

based on heuristic

inferred from DOI database lookup

Clozapine treatment increases serum glutamate and aspartate compared to conventional neuroleptics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

7 January 2021

based on heuristic

inferred from DOI database lookup

Placebo-controlled trial of glycine added to clozapine in schizophrenia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

7 January 2021

based on heuristic

inferred from DOI database lookup

D-cycloserine added to clozapine for patients with schizophrenia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

7 January 2021

based on heuristic

inferred from DOI database lookup

Control of NMDA receptor activation by a glycine transporter co-expressed in Xenopus oocytes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

7 January 2021

based on heuristic

inferred from DOI database lookup

Glycine transporters are differentially expressed among CNS cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

7 January 2021

based on heuristic

inferred from DOI database lookup

Cloning and functional characterization of a new subtype of the amino acid transport system N

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

7 January 2021

based on heuristic

inferred from DOI database lookup

Reversal of phencyclidine-induced hyperactivity by glycine and the glycine uptake inhibitor glycyldodecylamide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

7 January 2021

based on heuristic

inferred from DOI database lookup

Glutamine uptake by neurons: interaction of protons with system a transporters.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

7 January 2021

based on heuristic

inferred from DOI database lookup

Neuronal dependency of the glycine transporter GLYT1 expression in glial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential properties of two stably expressed brain-specific glycine transporters.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

7 January 2021

based on heuristic

inferred from DOI database lookup

Glycyldodecylamide, a phencyclidine behavioral antagonist, blocks cortical glycine uptake: implications for schizophrenia and substance abuse

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

7 January 2021

based on heuristic

inferred from DOI database lookup

ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

7 January 2021

based on heuristic

inferred from DOI database lookup

The glycine transporter type 1 inhibitor N-[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

7 January 2021

based on heuristic

inferred from DOI database lookup

Reversal of Phencyclidine-Induced Dopaminergic Dysregulation by N-Methyl-D-Aspartate Receptor/Glycine-site Agonists

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

7 January 2021

based on heuristic

inferred from DOI database lookup

Clozapine and seizures

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4001552

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.MP.4001552

1 reference

Europe PubMed Central

21 September 2017

1 reference

Europe PubMed Central

21 September 2017

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