(Q40537932)

21 September 2017

1 reference

title

The application of in vitro models of drug metabolism and toxicity in drug discovery and drug development (English)

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21 September 2017

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Ball SE

1

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21 September 2017

Scatina JA

series ordinal

2

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21 September 2017

Sisenwine SF

series ordinal

3

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21 September 2017

Fisher GL

series ordinal

4

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21 September 2017

publication date

1 February 1995

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Drug and Chemical Toxicology

21 September 2017

published in

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21 September 2017

volume

18

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21 September 2017

issue

1

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21 September 2017

page(s)

1-28

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Human cytochromes P450: problems and prospects

21 September 2017

cites work

1 reference

https://api.crossref.org/works/10.3109%2F01480549509017855

UDP-glucuronosyltransferases: a family of detoxifying enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549509017855

The pharmacokinetics of amlodipine in healthy volunteers after single intravenous and oral doses and after 14 repeated oral doses given once daily

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549509017855

Problems and opportunities in toxicity testing arising from species differences in xenobiotic metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549509017855

Metabolism of ciamexon by human liver microsomes: an investigation into the formation of stable, chemically reactive and cytotoxic metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549509017855

Predictive value of liver slices for metabolism and toxicity in vivo: use of acetaminophen as a model hepatotoxicant

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549509017855

Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549509017855

Correspondence of results from hepatocyte studies with in vivo response

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549509017855

Genetic polymorphisms of drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549509017855

The genetic polymorphism of debrisoquine/sparteine metabolism--clinical aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549509017855

Molecular genetics of the debrisoquin-sparteine polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549509017855

Genetic polymorphism of S-mephenytoin hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549509017855

The effects of erythromycin in patients treated with cyclosporine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549509017855

In- Vitro Hepatotoxicity of Three Dichlorobenzene Isomers in Human Liver Slices

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549509017855

Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549509017855

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549509017855

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549509017855

Recombinant DNA approaches for the development of metabolic systems used in in vitro toxicology

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549509017855

A metabolically competent human cell line expressing five cDNAs encoding procarcinogen-activating enzymes: application to mutagenicity testing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549509017855

Detection of human carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F01480549509017855

10.3109/01480549509017855

21 January 2018

Identifiers

DOI

1 reference

21 September 2017

1 reference