(Q40558195)

English

Molecular mechanisms of TNF-alpha-induced ceramide formation in human glioma cells: P53-mediated oxidant stress-dependent and -independent pathways

scientific article published on September 2004

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Molecular mechanisms of TNF-alpha-induced ceramide formation in human glioma cells: P53-mediated oxidant stress-dependent and -independent pathways (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

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author name string

Sawada M

1

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Kiyono T

2

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Nakashima S

3

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Shinoda J

4

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Naganawa T

5

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Hara S

6

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Iwama T

7

1 reference

Europe PubMed Central

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21 September 2017

Sakai N

8

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

publication date

1 September 2004

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21 September 2017

Cell Death & Differentiation

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Europe PubMed Central

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21 September 2017

11

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Europe PubMed Central

PubMed publication ID

21 September 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

997-1008

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Europe PubMed Central

PubMed publication ID

21 September 2017

https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401438

0 references

Tumour necrosis factor-alpha induces superoxide anion generation in mitochondria of L929 cells

1 reference

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Tumor necrosis factor receptor-mediated signaling pathways

1 reference

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21 January 2018

Oxidants as stimulators of signal transduction

1 reference

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Cytokine-induced modulation of tumor suppressor gene expression in ovarian cancer cells: up-regulation of p53 gene expression and induction of apoptosis by tumor necrosis factor-alpha.

1 reference

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21 January 2018

Tumor necrosis factor-alpha induces p53-dependent apoptosis in rat glioma cells

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21 January 2018

Resistance of MCF7 human breast carcinoma cells to TNF-induced cell death is associated with loss of p53 function

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Tumor necrosis factor-induced apoptosis stimulates p53 accumulation and p21WAF1 proteolysis in ME-180 cells

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p53 is involved in tumor necrosis factor-alpha-induced apoptosis in the human prostatic carcinoma cell line LNCaP.

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Reactive oxygen species are downstream mediators of p53-dependent apoptosis

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A model for p53-induced apoptosis

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p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2.

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Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death

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Cytokine-mediated induction of ceramide production is redox-sensitive. Implications to proinflammatory cytokine-mediated apoptosis in demyelinating diseases

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The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

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Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein

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Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

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p53 regulates ceramide formation by neutral sphingomyelinase through reactive oxygen species in human glioma cells

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Telomerase activation by the E6 gene product of human papillomavirus type 16.

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Cytochrome p450 epoxygenase metabolism of arachidonic acid inhibits apoptosis

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Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.

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Commitment to apoptosis is associated with changes in mitochondrial biogenesis and activity in cell lines conditionally immortalized with simian virus 40.

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Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis

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Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo.

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21 January 2018

The baculovirus p35 protein inhibits Fas- and tumor necrosis factor-induced apoptosis.

1 reference

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21 January 2018

Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway

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21 January 2018

Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c

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Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor

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Analysis of where and which types of proteinases participate in lysosomal proteinase processing using bafilomycin A1 and Helicobacter pylori Vac A toxin

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21 January 2018

Multiple pathways of TWEAK-induced cell death

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p53-dependent ceramide response to genotoxic stress

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Adenovirus-mediated wild-type-p53-gene expression sensitizes TNF-resistant tumor cells to TNF-induced cytotoxicity by altering the cellular redox state

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21 January 2018

Bcl-xL interrupts oxidative activation of neutral sphingomyelinase.

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21 January 2018

Ceramide induces hepatocyte cell death through disruption of mitochondrial function in the rat.

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Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis

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Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

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The regulation of reactive oxygen species production during programmed cell death

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Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells.

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21 January 2018

Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptotic pathway in glioma cells.

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A system for stable expression of short interfering RNAs in mammalian cells

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Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

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Ceramide Induces CytochromecRelease from Isolated Mitochondria

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Compartmentalization of ceramide signaling: physical foundations and biological effects

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Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

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Elevation of ceramide within distal neurites inhibits neurite growth in cultured rat sympathetic neurons

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Inhibition of rat cardiac muscle contraction and mitochondrial respiration by endogenous peroxynitrite formation during posthypoxic reoxygenation

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Selective involvement of superoxide anion, but not downstream compounds hydrogen peroxide and peroxynitrite, in tumor necrosis factor-alpha-induced apoptosis of rat mesangial cells

1 reference

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CA074 methyl ester: a proinhibitor for intracellular cathepsin B

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Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-alpha-induced cell death

1 reference

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Inhibition of neutral sphingomyelinase activation and ceramide formation by glutathione in hypoxic PC12 cell death

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Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide

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Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells

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Can the life span of human marrow stromal cells be prolonged by bmi-1, E6, E7, and/or telomerase without affecting cardiomyogenic differentiation?

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Identifiers

10.1038/SJ.CDD.4401438

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

Dimensions Publication ID

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 September 2017

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