(Q40575836)

21 September 2017

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title

GAD, diabetes, and Stiff-Man syndrome: some progress and more questions (English)

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21 September 2017

M Solimena

1

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21 September 2017

M H Butler

series ordinal

2

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21 September 2017

P De Camilli

series ordinal

3

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21 September 2017

1 July 1994

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Journal of Endocrinological Investigation

21 September 2017

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21 September 2017

17

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21 September 2017

7

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21 September 2017

509-520

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https://scigraph.springernature.com/pub.10.1007/bf03347745

21 September 2017

0 references

cites work

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21 January 2018

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Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome

21 January 2018

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Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

21 January 2018

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Identification and cloning of a granule autoantigen (carboxypeptidase-H) associated with type I diabetes

21 January 2018

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Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen

21 January 2018

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Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein

21 January 2018

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Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein.

21 January 2018

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No evidence for serological autoimmunity to islet cell heat shock proteins in insulin dependent diabetes

21 January 2018

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Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

21 January 2018

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Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice.

21 January 2018

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The structural and functional heterogeneity of glutamic acid decarboxylase: A review

21 January 2018

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Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10

21 January 2018

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Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene

21 January 2018

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Characterization of a cDNA coding for rat glutamic acid decarboxylase

21 January 2018

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Rat brain glutamic acid decarboxylase sequence deduced from a cloned cDNA.

21 January 2018

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Two genes encode distinct glutamate decarboxylases

21 January 2018

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Cloning, characterization, and autoimmune recognition of rat islet glutamic acid decarboxylase in insulin-dependent diabetes mellitus

21 January 2018

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Molecular Identification of the 62 kd Form of Glutamic Acid Decarboxylase from the Mouse

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03347745

Drosophila GABAergic Systems: Sequence and Expression of Glutamic Acid Decarboxylase

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03347745

Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain

21 January 2018

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Association of GAD-65, but not of GAD-67, with the Golgi complex of transfected Chinese hamster ovary cells mediated by the N-terminal region

21 January 2018

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Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03347745

A signal located within amino acids 1-27 of GAD65 is required for its targeting to the Golgi complex region

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03347745

Sequences homologous to glutamic acid decarboxylase cDNA are present on mouse chromosomes 2 and 10.

21 January 2018

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Regulatory properties of brain glutamate decarboxylase

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03347745

Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03347745

Cofactor interactions and the regulation of glutamate decarboxylase activity.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03347745

Immunohistochemical Studies of the GABA System in the Pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Glutamate decarboxylases in nonneural cells of rat testis and oviduct: differential expression of GAD65 and GAD67.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03347745

Differential expression of glutamic acid decarboxylase in rat and human islets

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03347745

Differential expression of GAD65 and GAD67 in human, rat, and mouse pancreatic islets.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03347745

Pathways to regulated exocytosis in neurons

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03347745

Amino acid neurotransmission: spotlight on synaptic vesicles

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03347745

Structural and functional considerations of GABA in islets of Langerhans. Beta-cells and nerves

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03347745

The amphicrine pancreatic cell line, AR42J, secretes GABA and amylase by separate regulated pathways

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF03347745

A gamma-aminobutyric acid transporter driven by a proton pump is present in synaptic-like microvesicles of pancreatic beta cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Autoantibodies to glutamic acid decarboxylase in a patient with stiff-man syndrome, epilepsy, and type I diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Stiff-person syndrome: an autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Stiff man syndrome: clinical and laboratory findings in eight patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

The stiff-man syndrome: new pathophysiological aspects from abnormal exteroceptive reflexes and the response to clomipramine, clonidine, and tizanidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Stiff-man syndrome updated

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Stiff-man syndrome: a GABAergic autoimmune disorder with autoantigenic heterogeneity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Exteroceptive reflexes abnormalities in stiff-man syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Anatomy, physiology, and pathology of epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Identification of a dominant epitope of glutamic acid decarboxylase (GAD-65) recognized by autoantibodies in stiff-man syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Plasma exchange and immunosuppression in the stiff man syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Autoantibodies to GABAergic neurons and response to plasmapheresis in stiff-man syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Autoimmunity in stiff man syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Age-dependent HLA genetic heterogeneity of type 1 insulin-dependent diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64K autoantibody positivity at onset predicts diabetes type

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Antibodies to Glutamic Acid Decarboxylase Discriminate Major Types of Diabetes Mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Recombinant glutamic acid decarboxylase (representing the single isoform expressed in human islets) detects IDDM-associated 64,000-M(r) autoantibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Human monoclonal islet specific autoantibodies share features of islet cell and 64 kDa antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Autoreactive epitopes defined by diabetes-associated human monoclonal antibodies are localized in the middle and C-terminal domains of the smaller form of glutamate decarboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Demonstration of GAD-65 as the main immunogenic isoform of glutamate decarboxylase in type 1 diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

An ELISA for antibodies to recombinant glutamic acid decarboxylase in IDDM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Autoantibodies to glutamic acid decarboxylase (GAD) detected by an immuno-trapping enzyme activity assay: Relation to insulin-dependent diabetes mellitus and islet cell antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Sudden death and paroxysmal autonomic dysfunction in stiff-man syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Inducible expression of H-2 and Ia antigens on brain cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Neuronal cells are deficient in loading peptides onto MHC class I molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Postnatal expression of glutamate decarboxylases in developing rat cerebellum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Antigen-specific immunotherapy: is it a real possibility to combat T-cell-mediated autoimmunity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Isolation of nonobese diabetic mouse T-cells that recognize novel autoantigens involved in the early events of diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

snRNPs and scRNPs as autoantigens: clues to the etiology of the connective tissue diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

T-cell clones from a type-1 diabetes patient respond to insulin secretory granule proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

An explanation for the protective effect of the MHC class II I–E molecule in murine diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Spotlight on a neuronal enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF03347745

Is juvenile diabetes a viral disease?

21 January 2018

1 reference

12 December 2020

"Cytoplasmic" islet cell antibodies. Evidence that the target antigen is a sialoglycoconjugate

1 reference

12 December 2020

Baculovirus-mediated expression of human 65 kDa and 67 kDa glutamic acid decarboxylases in SF9 insect cells and their relevance in diagnosis of insulin-dependent diabetes mellitus

1 reference

12 December 2020

No role for 65 kD heat-shock protein in diabetes

1 reference

12 December 2020

A role for synaptic vesicles in non-neuronal cells: clues from pancreatic beta cells and from chromaffin cells.

1 reference

12 December 2020

Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice

1 reference

12 December 2020

Cloning and sequence analysis of a murine cDNA encoding glutamate decarboxylase (GAD65).

1 reference

12 December 2020

Stiff-man syndrome, dysimmune disorder, and cancer

1 reference

12 December 2020

Pancreatic beta cells express two autoantigenic forms of glutamic acid decarboxylase, a 65-kDa hydrophilic form and a 64-kDa amphiphilic form which can be both membrane-bound and soluble

1 reference

12 December 2020

Characterization of the proteins purified with monoclonal antibodies to glutamic acid decarboxylase

1 reference

12 December 2020

Immunohistochemical localization of glutamate decarboxylase in the rat oviduct and ovary: further evidence for non-neural GABA systems

1 reference

12 December 2020

Prognostically significant heterogeneity of cytoplasmic islet cell antibodies in relatives of patients with type I diabetes

1 reference

12 December 2020

64,000 Mr autoantibodies as predictors of insulin-dependent diabetes

1 reference

12 December 2020

GABA and pancreatic beta-cells: colocalization of glutamic acid decarboxylase (GAD) and GABA with synaptic-like microvesicles suggests their role in GABA storage and secretion.

1 reference

12 December 2020

Organ-specific autoimmunity and HLA-DR antigens as markers for beta-cell destruction in patients with type II diabetes

1 reference

12 December 2020

A plant glutamate decarboxylase containing a calmodulin binding domain. Cloning, sequence, and functional analysis

1 reference

12 December 2020

Immune abnormalities in diabetic patients not requiring insulin at diagnosis

1 reference

12 December 2020

Human autoantibodies react with glutamic acid decarboxylase antigen in human and rat but not in mouse pancreatic islets

1 reference

12 December 2020

Association of HLA-DQB1*0201 with stiff-man syndrome

1 reference

12 December 2020

T-cell reactivity to 38 kD insulin-secretory-granule protein in patients with recent-onset type 1 diabetes

1 reference

12 December 2020

Binding of antibodies in sera from Type 1 (insulin-dependent) diabetic patients to glutamate decarboxylase from rat tissues. Evidence for antigenic and non-antigenic forms of the enzyme.

1 reference

12 December 2020

Plasmapheresis in the treatment of stiff-man syndrome

1 reference

12 December 2020

Regulatory properties of brain glutamate decarboxylase (GAD): the apoenzyme of GAD is present principally as the smaller of two molecular forms of GAD in brain

1 reference

12 December 2020

Autoantibodies to a 64-Kilodalton Islet Cell Protein Precede the Onset of Spontaneous Diabetes in the BB Rat

1 reference

12 December 2020

Ultrastructural immunocytochemical localization of L-glutamate decarboxylase and GABA in rat pancreatic zymogen granules

1 reference

12 December 2020

Progressive fluctuating muscular rigidity and spasm ("stiff-man" syndrome); report of a case and some observations in 13 other cases.

1 reference

12 December 2020

Autoimmunity to glutamic acid decarboxylase (GAD) in stiffman syndrome and insulin-dependent diabetes mellitus

1 reference

12 December 2020

The Stiff-Man syndrome

1 reference

12 December 2020

Mapping of glutamic acid decarboxylase (GAD) genes

1 reference

12 December 2020

Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes

1 reference

12 December 2020

Resolution of stiff-man syndrome with cortisol replacement in a patient with deficiencies of ACTH, growth hormone, and prolactin

1 reference

12 December 2020

A Bovine Albumin Peptide as a Possible Trigger of Insulin-Dependent Diabetes Mellitus

1 reference

12 December 2020

Glutamic acid decarboxylase cDNA: nucleotide sequence encoding an enzymatically active fusion protein.

1 reference

12 December 2020

The amino acid sequence of glutamate decarboxylase from Escherichia coli. Evolutionary relationship between mammalian and bacterial enzymes

1 reference

12 December 2020

T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis

1 reference

12 December 2020

Twin-to-twin pancreas transplantation: reversal and reenactment of the pathogenesis of type I diabetes

1 reference

12 December 2020

Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes

1 reference

12 December 2020

Expression of the neurotransmitter-synthesizing enzyme glutamic acid decarboxylase in male germ cells

1 reference

12 December 2020

1 reference

12 December 2020

Delay in onset of insulitis in NOD mice following a single injection of CD 4 and CD8 antibodies

1 reference

12 December 2020

Insulin Antibodies in Insulin-Dependent Diabetics Before Insulin Treatment

1 reference

12 December 2020

Breaking T cell tolerance with foreign and self co-immunogens. A study of autoimmune B and T cell epitopes of cytochrome c

1 reference

12 December 2020

Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms

1 reference

12 December 2020

Glutamic acid decarboxylase in brain.

1 reference

12 December 2020

Localization and quantitation of expression of two glutamate decarboxylase genes in pancreatic beta-cells and other peripheral tissues of mouse and rat.

1 reference

12 December 2020

The Potential of Restricted T Cell Recognition of Myelin Basic Protein Epitopes in the Therapy of Multiple Sclerosis

1 reference

12 December 2020

Differential expression and regulation of MHC products in the endocrine and exocrine cells of the human pancreas

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF03347745

1 reference

Dimensions Publication ID

21 September 2017

0 references

1 reference