(Q40579202)

21 September 2017

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title

Polymer conjugates. Pharmacokinetic considerations for design and development (English)

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21 September 2017

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R Duncan

1

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21 September 2017

F Spreafico

series ordinal

2

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21 September 2017

publication date

1 October 1994

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Clinical Pharmacokinetics

21 September 2017

published in

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21 September 2017

volume

27

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21 September 2017

issue

4

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21 September 2017

page(s)

290-306

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https://scigraph.springernature.com/pub.10.2165/00003088-199427040-00004

21 September 2017

exact match

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cites work

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A phase II trial of PEG-L-asparaginase in the treatment of non-Hodgkins lymphoma

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Modification of human hemoglobin with polyethylene glycol : a new candidate for blood substitute

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12 December 2020

Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers.

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Modification of hemoglobin upon covalent coupling to dextran: enhanced stability against acid denaturation and reduced affinity for haptoglobin

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12 December 2020

Effect of arterial administration of high-molecular-weight anticancer agent SMANCS with lipid lymphographic agent on hepatoma: a preliminary report

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PEG superoxide dismutase derivatives: anti-inflammatory activity in carrageenan pelurisy in rats

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12 December 2020

Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol

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12 December 2020

Characterization of polyethylene glycol-modified L-asparaginase from Escherichia coli and its application to therapy of leukemia

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12 December 2020

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs

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12 December 2020

Preparation and properties of polyethylene glycol-trypsin adducts

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12 December 2020

The effect of chemical modification of L-asparaginase on its persistence in circulating blood of animals

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12 December 2020

Biocompatibility of N-(2-hydroxypropyl) methacrylamide copolymers containing adriamycin. Immunogenicity, and effect on haematopoietic stem cells in bone marrow in vivo and mouse splenocytes and human peripheral blood lymphocytes in vitro

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12 December 2020

Drug-polymer conjugates: potential for improved chemotherapy

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12 December 2020

Pharmacokinetics of recombinant interleukin 2 in humans

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12 December 2020

Binding of Covalent Proteins to Polysaccharides by Cyanogen Bromide and Organic Cyanates. I. Preparation of Soluble Glycine-, Insulin- and Ampicillin-dextran

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12 December 2020

Preclinical trials with combinations and conjugates of T101 monoclonal antibody and doxorubicin

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12 December 2020

Immunologic responses to conjugates of antigen E in patients with ragweed hay fever

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12 December 2020

Controlled biodegradability of polymers — a key to drug delivery systems

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12 December 2020

Tyrosinamide residues enhance pinocytic capture of N-(2-hydroxypropyl)methacrylamide copolymers

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12 December 2020

Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. II. Evaluation of daunomycin conjugates in vivo against L1210 leukaemia

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12 December 2020

Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood

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12 December 2020

Comparison of the liver subcellular distribution of free daunomycin and that bound to galactosamine targeted N-(2-hydroxypropyl)methacrylamide copolymers, following intravenous administration in the rat

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12 December 2020

Treatment of adenosine deaminase deficiency with polyethylene glycol-modified adenosine deaminase

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12 December 2020

Enhanced plasma persistence of therapeutic enzymes by coupling to soluble dextran

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12 December 2020

Influence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier

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12 December 2020

Distribution and mechanism of clearance of L-asparaginase (NSC-109229).

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12 December 2020

Synthesis, isolation, and characterization of conjugates of ovalbumin with monomethoxypolyethylene glycol using cyanuric chloride as the coupling agent

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12 December 2020

Preparation of a polyethylene glycol: superoxide dismutase adduct, and an examination of its blood circulation life and anti-inflammatory activity

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12 December 2020

Degradation of side-chains of N-(2-hydroxypropyl)methacrylamide copolymers by lysosomal thiol-proteinases

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12 December 2020

Reduced bone marrow toxicity of neocarzinostatin by conjugation with divinyl ether-maleic acid copolymer

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12 December 2020

Tolerogenic polyethylene glycol derivatives of xenogeneic monoclonal immunoglobulins

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12 December 2020

High efficacy of monomethoxypolyethylene glycolconjugated l-asparaginase (PEG2-ASP) in two patients with hematological malignancies

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12 December 2020

Pharmacokinetics of recombinant human granulocyte colony-stimulating factor conjugated to polyethylene glycol in rats

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12 December 2020

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12 December 2020

Preparation of polyethylene glycol-tissue plasminogen activator adducts that retain functional activity: characteristics and behavior in three animal species

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12 December 2020

Preparation of a non-immunogenic arginase by the covalent attachment of polyethylene glycol

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12 December 2020

Hypouricaemic effect of polyethyleneglycol modified urate oxidase

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12 December 2020

Use of polyethylene glycol-modified uricase (PEG-uricase) to treat hyperuricemia in a patient with non-Hodgkin lymphoma

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12 December 2020

Receptor-mediated gene delivery and expression in vivo.

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12 December 2020

Chemical engineering of the monoclonal antibody A7 by polyethylene glycol for targeting cancer chemotherapy

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12 December 2020

Properties of two urate oxidases modified by the covalent attachment of poly(ethylene glycol)

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12 December 2020

Some properties of polyethylene glycol:phenylalanine ammonia-lyase adducts

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12 December 2020

The pharmacokinetics of polymer-bound adriamycin

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12 December 2020

The uses and properties of PEG-linked proteins

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12 December 2020

Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo.

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12 December 2020

Chemical modification of recombinant interleukin 2 by polyethylene glycol increases its potency in the murine Meth A sarcoma model

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12 December 2020

Clinical pharmacology of polyethylene glycol-L-asparaginase

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12 December 2020

Lipase modified for solubility in organic solvents

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12 December 2020

Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase

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12 December 2020

Preparation, properties and antileukemic activity of arabinosylcytosine polysaccharide conjugates

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12 December 2020

Pharmacological and therapeutic properties of carrier bound methotrexate against tumor confined to a third space body compartment

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12 December 2020

Chemical modification of alpha-thrombin and in vitro characterization of its anticoagulant activity

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12 December 2020

Antitumor activity of monomeric and polymeric cyclophosphamide derivatives compared with in vitro hydrolysis

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12 December 2020

SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy

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12 December 2020

Reduction of immunogenicity by covalent modification of murine and rabbit immunoglobulins with oxidized dextrans of low molecular weight

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12 December 2020

Clinical experiences with polyethylene glycol-bound E. coli L-asparaginase in patients with multiple recurrences of acute lymphoblastic leukemia

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12 December 2020

Fate of N-(2-hydroxypropyl)methacrylamide copolymers with pendent galactosamine residues after intravenous administration to rats

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12 December 2020

The development of anti-interleukin-2 antibodies in patients treated with recombinant human interleukin-2 (IL-2)

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12 December 2020

Use of oily contrast medium for selective drug targeting to tumor: enhanced therapeutic effect and X-ray image

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12 December 2020

Modification of amino groups in porcine pancreatic elastase with polyethylene glycol in relation to binding ability towards anti-serum and to enzymic activity

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12 December 2020

[Soluble high molecular weight derivatives of pancreatic trypsin inhibitor. Modification of pancreatic trypsin inhibitor by soluble polysaccharides activated by titanium tetrachloride]

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12 December 2020

Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran. I: Synthesis and characterization

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12 December 2020

Passive tumor targeting of soluble macromolecules and drug conjugates

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12 December 2020

Polymeric drug-carriers containing doxorubicin and melanocyte-stimulating hormone: in vitro and in vivo evaluation against murine melanoma

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12 December 2020

Effects of monomethoxypoly(ethylene glycol) modification of ribonuclease on antibody recognition, substrate accessibility and conformational stability

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12 December 2020

Targeting of N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugate to the hepatocyte galactose-receptor in mice: visualisation and quantification by gamma scintigraphy as a basis for clinical targeting studies

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12 December 2020

A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone

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12 December 2020

Schedule dependency of the antitumor activity and toxicity of polyethylene glycol-modified interleukin 2 in murine tumor models.

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12 December 2020

Stabilization of Human beta-D-N-Acetylhexosaminidase A towards Proteolytic Inactivation by Coupling It to Poly(N-vinylpyrrolidone)

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12 December 2020

Enzyme therapy: II. Effect of covalent attachment of polyethylene glycol on biochemical parameters and immunological determinants of beta-glucosidase and alpha-galactosidase

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12 December 2020

Studies on the effect of PEG-modified urokinase on coagulation-fibrinolysis using beagles

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12 December 2020

Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats.

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12 December 2020

N-(2-Hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose-receptor: pharmacokinetics in DBA2 mice

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12 December 2020

Adenosine deaminase deficiency with late onset of recurrent infections: response to treatment with polyethylene glycol-modified adenosine deaminase

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12 December 2020

Modification of E. coli L-asparaginase with polyethylene glycol: Disappearance of binding ability to anti-asparaginase serum

1 reference

12 December 2020

Conjugation of poly(styrene-co-maleic acid) derivatives to the antitumor protein neocarzinostatin: pronounced improvements in pharmacological properties

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12 December 2020

Tumoritropic and lymphotropic principles of macromolecular drugs

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12 December 2020

Antibody responses to honey-bee venom and monomethoxy-polyethylene glycol-modified honey-bee venom in mice

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12 December 2020

Reduction of plasma urate levels in the cockerel with polyethylene glycol-uricase

1 reference

12 December 2020

Pharmacokinetic properties of polyethylene glycol derivatized superoxide dismutase

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12 December 2020

Suppression of reaginic antibodies with modified allergens. III. Preparation of tolerogenic conjugates of common allergens with monomethoxypolyethylene glycols of different molecular weights by the mixed anhydride method

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12 December 2020

Comparison of antitumor effects of daunorubicin covalently linked to poly-L-amino acid carriers

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12 December 2020

Changes in the toxicity and therapeutic efficacy of daunorubicin linked with a biodegradable carrier

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12 December 2020

Cell separation by immunoaffinity partitioning with polyethylene glycol-modified protein a in aqueous polymer two-phase systems

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12 December 2020

A new procedure for the synthesis of polyethylene glycol-protein adducts; Effects on function, receptor recognition, and clearance of superoxide dismutase, lactoferrin, and α2-macroglobulin

1 reference

12 December 2020

A nonantigenic covalent streptokinase-polyethylene glycol complex with plasminogen activator function

1 reference

12 December 2020

Application of polyvinylpyrrolidone as a carrier for kallikrein

1 reference

12 December 2020

Selective tumor localization and improved therapeutic index of anthracyclines encapsulated in long-circulating liposomes

1 reference

12 December 2020

Higher Antitumor Efficacy of Daunomycin When Linked to Dextran: In Vivo and In Vitro Studies 2

1 reference

12 December 2020

Use of site-directed mutagenesis to enhance the epitope-shielding effect of covalent modification of proteins with polyethylene glycol

1 reference

12 December 2020

Reduced cardiotoxicity of doxorubicin given in the form of N-(2-hydroxypropyl)methacrylamide conjugates: and experimental study in the rat

1 reference

12 December 2020

A phase I study including pharmacokinetics of polyethylene glycol conjugated interleukin-2.

1 reference

12 December 2020

Activity of N-(2-hydroxypropyl)methacrylamide copolymers containing daunomycin against a rat tumour model

1 reference

12 December 2020

10.2165/00003088-199427040-00004

Identifiers

DOI

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Dimensions Publication ID

21 September 2017

1002144695

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