(Q40590105)

21 September 2017

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title

Topoisomerase II enzymes and mutagenicity (English)

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21 September 2017

Ferguson LR

1

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21 September 2017

Baguley BC

series ordinal

2

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21 September 2017

publication date

1 January 1994

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Environmental and Molecular Mutagenesis

21 September 2017

published in

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21 September 2017

volume

24

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21 September 2017

issue

4

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21 September 2017

page(s)

245-261

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International Commission for Protection Against Environmental Mutagens and Carcinogens. Mutagenicity and carcinogenicity of topoisomerase-interactive agents

21 September 2017

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21 January 2018

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Site-specific DNA cleavage by mammalian DNA topoisomerase II induced by novel flavone and catechin derivatives

21 January 2018

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Cytogenetical characterization of Chinese hamster ovary X-ray-sensitive mutant cells, xrs 5 and xrs 6. IV. Study of chromosomal aberrations and sister-chromatid exchanges by restriction endonucleases and inhibitors of DNA topoisomerase II.

21 January 2018

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Prophage induction by DNA topoisomerase II poisons and reactive-oxygen species: role of DNA breaks

21 January 2018

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DNA topoisomerases and models of sister-chromatid exchange

21 January 2018

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The relationship between frameshift mutagenicity and DNA-binding affinity in a series of acridine-substituted derivatives of the experimental antitumour drug 4'-(9-acridinylamino)methanesulphonanilide (AMSA).

21 January 2018

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Chromosomal changes in Chinese hamster AA8 cells caused by podophyllin, a common treatment for genital warts

21 January 2018

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Meiosis-specific arrest revealed in DNA topoisomerase II mutants

21 January 2018

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Apoptosis (the 1992 Frank Rose Memorial Lecture).

21 January 2018

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Chromosome assembly in vitro: Topoisomerase II is required for condensation

21 January 2018

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7 January 2021

Etoposide (VP-16): cytogenetic studies in mice

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https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Implication of prior treatment with drug combinations including inhibitors of topoisomerase II in therapy-related monocytic leukemia with a 9;11 translocation

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https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Potent clastogenicity of the human carcinogen etoposide to the mouse bone marrow and mouse lymphoma L5178Y cells: comparison to Salmonella responses.

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https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Genotoxicity of inhibitors of DNA topoisomerases I (camptothecin) and II (m-AMSA) in vivo and in vitro

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https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Illegitimate recombination mediated by calf thymus DNA topoisomerase II in vitro

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https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

A shuttle vector for analysis of illegitimate recombination in mammalian cells: effects of DNA topoisomerase inhibitors on deletion frequency

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https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Inverse correlation between bacterial frameshift mutagenicity and yeast mitochondrial effects of antitumour anilinoacridines.

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https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

DNA binding and growth inhibitory properties of a series of 2,7-di-alkyl-substituted derivatives of proflavine.

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https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Etoposide (VP-16-213)-induced gene alterations: potential contribution to cell death

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https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Protein:DNA interactions at chromosomal loop attachment sites.

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https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

A proflavin-induced frameshift hotspot in the thymidylate synthase gene of bacteriophage T4

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https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

DNA topoisomerase II is required for formation of mitotic chromosomes in Chinese hamster ovary cells: studies using the inhibitor 4'-demethylepipodophyllotoxin 9-(4,6-O-thenylidene-beta-D-glucopyranoside).

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Chromosome recombination and defective genome segregation induced in Chinese hamster cells by the topoisomerase II inhibitor VM-26

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Mitotic recombination in the rDNA of S. cerevisiae is suppressed by the combined action of DNA topoisomerases I and II.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

The effect of acridine compounds on sister-chromatid exchange formation in cultured human lymphocytes

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Bacterial and mammalian cell mutagenesis, sister-chromatid exchange, and mouse lung adenoma bioassay with the antineoplastic acridine derivative amsacrine.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Apoptotic cell death triggered by camptothecin or teniposide. The cell cycle specificity and effects of ionizing radiation

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Mutagenicity of topoisomerase-active agents in bacteriophage T4

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Mutagenicity and clastogenicity of teniposide (VM-26) in L5178Y/TK +/- -3.7.2C mouse lymphoma cells

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Mutagenicity of m-AMSA and o-AMSA in mammalian cells due to clastogenic mechanism: possible role of topoisomerase

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Molecular analysis of mutations induced by the intercalating agent ellipticine at the hisD3052 allele of Salmonella typhimurium TA98.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Inhibitors of DNA topoisomerase II prevent chromatid separation in mammalian cells but do not prevent exit from mitosis

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Topoisomerase II is a structural component of mitotic chromosome scaffolds.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Cell cycle stage dependent variations in drug-induced topoisomerase II mediated DNA cleavage and cytotoxicity

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Apparent changes in structure-activity relationships for antimitochondrial effects of 9-anilinoacridines according to Saccharomyces cerevisiae strain and methodology.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Induction of petite formation in Saccharomyces cerevisiae by experimental antitumour agents. Structure--activity relationships for 9-anilinoacridines

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Potential antitumor agents. 30. Mutagenic activity of some 9-anilinoacridines: relationships between structure, mutagenic potential, and antileukemic activity

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Potential antitumor agents. 33. Quantitative structure--activity relationships for mutagenic activity and antitumor activity of substituted 4'-(9-acridinylamino)methanesulfonanilide derivatives.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Frameshift mutagenesis by acridines and other reversibly-binding DNA ligands

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Mitotic crossing-over by anticancer drugs in Saccharomyces cerevisiae strain D5

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Comparative studies of mutagenic, DNA binding and antileukaemic properties of 9-anilinoacridine derivatives and related compounds

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Morphological transformation and chromosome damage by amsacrine in C3H/10T1/2 clone 8 cells.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Comparison of the mutagenicity of amsacrine with that of a new clinical analogue, CI-921.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Mutagenicity profiles of newer amsacrine analogues with activity against solid tumours: comparison of microbial and mammalian systems

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Genetic toxicology of tricyclic carboxamides, a new class of DNA binding antitumour agent.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Induction of mitotic crossing-over by the topoisomerase II poison DACA (N-[2-dimethylamino)ethyl]acridine-4-carboxamide) in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Chemoprotection by 9-aminoacridine derivatives against the cytotoxicity of topoisomerase II-directed drugs

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

DNA gyrase: an enzyme that introduces superhelical turns into DNA

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Regulation of DNA Supercoiling in Escherichia coli

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

A restudy of the efficacy of adriamycin in inducing dominant lethals in mouse spermatogonia stems cells

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Apoptosis of S-phase HL-60 cells induced by DNA topoisomerase inhibitors: detection of DNA strand breaks by flow cytometry using the in situ nick translation assay

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Yeast DNA topoisomerase II is encoded by a single-copy, essential gene

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Tests for the genotoxicity of m-AMSA, etoposide, teniposide and ellipticine in Neurospora crassa

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Etoposide (VP16) and teniposide (VM26): novel anticancer drugs, strongly mutagenic in mammalian but not prokaryotic test systems.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Effects of etoposide on stage-specific DNA synthesis during rat spermatogenesis

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Cytokinetic differences in the action of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide as compared with that of amsacrine and doxorubicin

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Small deletion and insertion mutations induced by the topoisomerase II inhibitor teniposide in CHO cells and comparison with sites of drug-stimulated DNA cleavage in vitro

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Epipodophyllotoxins, alkylating agents, and radiation and risk of secondary leukaemia after childhood cancer

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Topoisomerase II does not play a scaffolding role in the organization of mitotic chromosomes assembled in Xenopus egg extracts

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Genetic profile of a nalidixic acid analog: a model for the mechanism of sister chromatid exchange induction

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

DNA topoisomerase II is required at the time of mitosis in yeast

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Illegitimate recombination mediated by T4 DNA topoisomerase in vitro. Recombinants between phage and plasmid DNA molecules.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Redox chemistry of the 9-anilinoacridine class of antitumor agents

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Tannins as potent inhibitors of DNA topoisomerase II in vitro

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Localization of RAP1 and topoisomerase II in nuclei and meiotic chromosomes of yeast

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

4-Quinolones cause a selective loss of mitochondrial DNA from mouse L1210 leukemia cells

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

A new Salmonella tester strain (TA102) with A X T base pairs at the site of mutation detects oxidative mutagens

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

DNA topoisomerase poisons as antitumor drugs

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Inhibitors of topoisomerase II: structure-activity relationships and mechanism of action of podophyllin congeners.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Tandem regions of yeast DNA topoisomerase II share homology with different subunits of bacterial gyrase.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Genotoxic classification of anticancer drugs.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Frameshift mutations: relative roles of simple intercalation and of adduct formation.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Anti-topoisomerase II recognizes meiotic chromosome cores

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Mutagenesis of L5178Y/TK(+/-)-3.7.2C mouse lymphoma cells by the clastogen ellipticine

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Mutagenicity and clastogenicity of adriamycin in L5178Y/TK(+/-)-3.7.2C mouse lymphoma cells

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Site-specific cleavage of DNA by E. coli DNA gyrase

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Topoisomerase inhibitors induce apoptosis in thymocytes

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Localization of DNA topoisomerase II in Chinese hamster fibroblasts by confocal and electron microscopy

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

DNA topoisomerases and the DNA lesion in human genetic instability syndromes

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

In vivo exposure to four ellipticine derivatives with topoisomerase inhibitory activity results in chromosome clumping and sister chromatid exchange in murine bone marrow cells

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Deletion and duplication sequences induced in CHO cells by teniposide (VM-26), a topoisomerase II targeting drug, can be explained by the processing of DNA nicks produced by the drug-topoisomerase interaction

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Hotspot sites for acridine-induced frameshift mutations in bacteriophage T4 correspond to sites of action of the T4 type II topoisomerase

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

The topoisomerase II inhibitor VM-26 induces marked changes in histone H1 kinase activity, histones H1 and H3 phosphorylation, and chromosome condensation in G2 phase and mitotic BHK cells

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

The capture of a DNA double helix by an ATP-dependent protein clamp: a key step in DNA transport by type II DNA topoisomerases

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Secondary acute myeloid leukemia in children previously treated with alkylating agents, intercalating topoisomerase II inhibitors, and irradiation

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Cell line selectivity and DNA breakage properties of the antitumour agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide: role of DNA topoisomerase II.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Sister chromatid separation in frog egg extracts requires DNA topoisomerase II activity during anaphase

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Fertility, reproduction, and genetic disease: studies on the mutagenic effects of environmental agents on mammalian germ cells

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Micronuclei in neonatal lymphocytes treated with the topoisomerase II inhibitors amsacrine and etoposide

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Identification of a structural protein component of rat synaptonemal complexes

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Dysfunction of chromosomal loop attachment sites: illegitimate recombination linked to matrix association regions and topoisomerase II.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Eukaryotic topoisomerase II preferentially cleaves alternating purine-pyrimidine repeats

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Mechanism of action of nalidixic acid: Purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

DNA gyrase subunit stoichiometry and the covalent attachment of subunit A to DNA during DNA cleavage

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Scanning electron microscopy of mammalian chromosomes from prophase to telophase

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Multiple chromosomal populations of topoisomerase II detected in vivo by time-lapse, three-dimensional wide-field microscopy

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Measurement of low levels of x-ray mutagenesis in relation to human disease

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

The role of DNA topoisomerases in recombination and genome stability: a double-edged sword?

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Teniposide, a topoisomerase II inhibitor, prevents chromosome condensation and separation but not decondensation in fertilized surf clam (Spisula solidissima) oocytes

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Structure of the Drosophila DNA topoisomerase II gene. Nucleotide sequence and homology among topoisomerases II.

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Induction of mammalian topoisomerase II dependent DNA cleavage by nonintercalative flavonoids, genistein and orobol

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

The 180-kDa isoform of topoisomerase II is localized in the nucleolus and belongs to the structural elements of the nucleolar remnant

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Polyploidy induction as a consequence of topoisomerase inhibition. A flow cytometric assessment

1 reference

https://api.crossref.org/works/10.1002%2FEM.2850240402

7 January 2021

Identifiers

DOI

10.1002/EM.2850240402

1 reference

21 September 2017

1 reference