(Q40593829)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14754889%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

title

Squalestatin cures prion-infected neurons and protects against prion neurotoxicity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14754889%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

0 references

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14754889%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

author name string

Clive Bate

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14754889%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

Luisa Diomede

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14754889%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

Alun Williams

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14754889%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

language of work or name

English

0 references

publication date

29 January 2004

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14754889%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

17 November 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14754889%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

volume

279

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14754889%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

issue

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14754889%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

page(s)

14983-14990

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14754889%20AND%20SRC:MED&resulttype=core&format=json

PrP deposition, microglial activation, and neuronal apoptosis in murine scrapie.

17 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Novel proteinaceous infectious particles cause scrapie

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Mice devoid of PrP are resistant to scrapie

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Normal host prion protein necessary for scrapie-induced neurotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Functional rafts in cell membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia: evidence that simvastatin affects cholesterol metabolism in the human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Cardioprotective actions of acute HMG-CoA reductase inhibition in the setting of myocardial infarction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

In vivo anti-inflammatory effect of statins is mediated by nonsterol mevalonate products

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Cytoprotective effect of NMDA receptor antagonists on prion protein (PrionSc)-induced toxicity in rat cortical cell cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Neurotoxicity of a prion protein fragment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Synthetic miniprion PrP106.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Cyclo-oxygenase inhibitors protect against prion-induced neurotoxicity in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Microglial cells respond to amyloidogenic PrP peptide by the production of inflammatory cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Killing of prion-damaged neurones by microglia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Role of microglia and host prion protein in neurotoxicity of a prion protein fragment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Effects of S-2474, a novel nonsteroidal anti-inflammatory drug, on amyloid beta protein-induced neuronal cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

How cells handle cholesterol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Effects of statins on human cerebral cholesterol metabolism and secretion of Alzheimer amyloid peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Stimulation of PrP(C) retrograde transport toward the endoplasmic reticulum increases accumulation of PrP(Sc) in prion-infected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Filipin prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP release

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Extraction of cholesterol with methyl-beta-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Cholesterol depletion by methyl-beta-cyclodextrin blocks cholera toxin transport from endosomes to the Golgi apparatus in hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Apoptosis-mediated neurotoxicity induced by beta-amyloid and PrP fragments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Association of p75(NTR) with caveolin and localization of neurotrophin-induced sphingomyelin hydrolysis to caveolae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Neurotrophin p75 receptor is involved in neuronal damage by prion peptide-(106-126).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Compartmentation of cyclic adenosine 3',5'-monophosphate signaling in caveolae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Cellular prion protein transduces neuroprotective signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Lipid rafts are enriched in arachidonic acid and plasmenylethanolamine and their composition is independent of caveolin-1 expression: a quantitative electrospray ionization/mass spectrometric analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Colocalization and interaction of cyclooxygenase-2 with caveolin-1 in human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Immunocytochemical appearance of cytokines, prostaglandin E2 and lipocortin-1 in the CNS during the incubation period of murine scrapie correlates with progressive PrP accumulations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Endocytic Intermediates Involved with the Intracellular Trafficking of a Fluorescent Cellular Prion Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Synapse loss associated with abnormal PrP precedes neuronal degeneration in the scrapie-infected murine hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

The expanding role of HMG-CoA reductase inhibitors (statins) in the prevention and treatment of ischemic heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Isoprenylated proteins in cultured cells: subcellular distribution and changes related to altered morphology and growth arrest induced by mevalonate deprivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Precise targeting of the pathology of the sialoglycoprotein, PrP, and vacuolar degeneration in mouse scrapie

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Increased brain synthesis of prostaglandin E2 and F2-isoprostane in human and experimental transmissible spongiform encephalopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

A rapid, quantitative immunofunctional assay for measuring human leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

Temporal and spatial relationship between the death of PrP-damaged neurones and microglial activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M313061200

21 January 2018

Identifiers

DOI

10.1074/JBC.M313061200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14754889%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

1 reference