(Q40596817)

English

Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016.

scientific article published on January 2004

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scholarly article

1 reference

Europe PubMed Central

21 September 2017

Truncated ErbB2 receptor (p95ErbB2) is regulated by heregulin through heterodimer formation with ErbB3 yet remains sensitive to the dual EGFR/ErbB2 kinase inhibitor GW572016. (English)

1 reference

Europe PubMed Central

21 September 2017

author name string

Wenle Xia

1

1 reference

Europe PubMed Central

21 September 2017

Lei-Hua Liu

2

1 reference

Europe PubMed Central

21 September 2017

Peter Ho

3

1 reference

Europe PubMed Central

21 September 2017

Neil L Spector

4

1 reference

Europe PubMed Central

21 September 2017

language of work or name

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publication date

1 January 2004

1 reference

Europe PubMed Central

21 September 2017

1 reference

Europe PubMed Central

21 September 2017

23

1 reference

Europe PubMed Central

21 September 2017

646-653

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Europe PubMed Central

21 September 2017

3

1 reference

Europe PubMed Central

21 September 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1207166

0 references

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

1 reference

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Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease

1 reference

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Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2.

1 reference

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c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes

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21 January 2018

Epidermal growth factor receptors: critical mediators of multiple receptor pathways

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Soluble c-erbB-2 fragment in serum correlates with disease stage and predicts for shortened survival in patients with early-stage and advanced breast cancer

1 reference

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Expression of the ERBB3 gene product in breast cancer

1 reference

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21 January 2018

Involvement of pp60c-src with two major signaling pathways in human breast cancer

1 reference

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21 January 2018

Epidermal growth factor-related peptides and their receptors in human malignancies

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Structural alterations of the epidermal growth factor receptor gene in human gliomas

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AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival

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7 January 2021

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Oncogenic activation of the neu-encoded receptor protein by point mutation and deletion

1 reference

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7 January 2021

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Neu differentiation factor activation of ErbB-3 and ErbB-4 is cell specific and displays a differential requirement for ErbB-2.

1 reference

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7 January 2021

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The c-erbB transmembrane growth factor receptors as serum biomarkers in human cancer studies

1 reference

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erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells

1 reference

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7 January 2021

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ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

1 reference

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7 January 2021

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New model of ErbB-2 over-expression in human mammary luminal epithelial cells

1 reference

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ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner

1 reference

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7 January 2021

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The type I growth factor receptors in human breast cancer

1 reference

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7 January 2021

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Specificity within the EGF family/ErbB receptor family signaling network

1 reference

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7 January 2021

based on heuristic

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Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene

1 reference

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7 January 2021

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Strain-dependent epithelial defects in mice lacking the EGF receptor

1 reference

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7 January 2021

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Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207166

7 January 2021

based on heuristic

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Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

1 reference

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7 January 2021

based on heuristic

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ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207166

7 January 2021

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Matrix metalloproteinases in tumor invasion and metastasis

1 reference

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7 January 2021

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Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype

1 reference

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7 January 2021

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Blockage of heregulin expression inhibits tumorigenicity and metastasis of breast cancer

1 reference

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7 January 2021

based on heuristic

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A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207166

7 January 2021

based on heuristic

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Signal transduction by receptors with tyrosine kinase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207166

7 January 2021

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

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Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function

1 reference

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7 January 2021

based on heuristic

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Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways

1 reference

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7 January 2021

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Prediction of response to antiestrogen therapy in advanced breast cancer patients by pretreatment circulating levels of extracellular domain of the HER-2/c-neu protein

1 reference

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7 January 2021

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inferred from DOI database lookup

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10.1038/SJ.ONC.1207166

1 reference

Europe PubMed Central

21 September 2017

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1 reference

Europe PubMed Central

21 September 2017

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