(Q40601029)

21 September 2017

title

Intravenous infusion of a replication-selective adenovirus (ONYX-015) in cancer patients: safety, feasibility and biological activity (English)

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21 September 2017

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Nemunaitis J

1

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21 September 2017

Cunningham C

2

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21 September 2017

Buchanan A

3

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21 September 2017

Blackburn A

4

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21 September 2017

Edelman G

5

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21 September 2017

Maples P

6

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21 September 2017

Netto G

7

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21 September 2017

Tong A

8

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21 September 2017

Randlev B

9

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21 September 2017

Olson S

10

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21 September 2017

Kirn D

11

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21 September 2017

publication date

1 May 2001

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21 September 2017

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21 September 2017

volume

8

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21 September 2017

issue

10

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21 September 2017

page(s)

746-759

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Adenovirus-mediated correction of the genetic defect in hepatocytes from patients with familial hypercholesterolemia

21 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Gene therapy for cancer: what have we done and where are we going?

21 January 2018

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Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant

21 January 2018

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Replication-selective microbiological agents: fighting cancer with targeted germ warfare

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Replication-selective adenoviruses as oncolytic agents

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

A Novel Three-Pronged Approach to Kill Cancer Cells Selectively: Concomitant Viral, Double Suicide Gene, and Radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

NAS report under scrutiny.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

p53 and DNA polymerase alpha compete for binding to SV40 T antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Clinical implications of the p53 tumor-suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Toxicological Comparison of E2a-Deleted and First-Generation Adenoviral Vectors Expressingα1-Antitrypsin after Systemic Delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Upregulation of class I major histocompatibility complex antigens by interferon gamma is necessary for T-cell-mediated elimination of recombinant adenovirus-infected hepatocytes in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Effects of liposome-encapsulated dichloromethylene diphosphonate on macrophage function and endotoxin-induced mortality

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

The liposome-mediated macrophage 'suicide' technique

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Early events in the interaction of adenoviruses with HeLa cells. I. Penetration of type 5 and intracellular release of the DNA genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Rac GTPase interacts specifically with phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Phosphatidylinositol-3-OH kinase as a direct target of Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Rho Family GTPases Bind to Phosphoinositide Kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Assessment of recombinant adenoviral vectors for hepatic gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Role of adenovirus antigens in the induction of virus neutralizing antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4Ig administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Anti-T cell receptor monoclonal antibody prolongs transgene expression following adenovirus-mediated in vivo gene transfer to mouse synovium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Suppression of the immune response to an adenovirus vector and enhancement of intratumoral transgene expression by low-dose etoposide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Gene Therapy for Hemophilia B: Host Immunosuppression Prolongs the Therapeutic Effect of Adenovirus-Mediated Factor IX Expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

FK506 immunosuppression to control the immune reactions triggered by first-generation adenovirus-mediated gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Adenovirus proteins that subvert host defenses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Region E3 of adenovirus: A cassette of genes involved in host immunosurveillance and virus-cell interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Characterization of factors involved in modulating persistence of transgene expression from recombinant adenovirus in the mouse lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

Immunosuppression by FK506 markedly prolongs expression of adenovirus-delivered transgene in skeletal muscles of adult dystrophic [mdx] mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

The early region 1B 55-kilodalton oncoprotein of adenovirus relieves growth restrictions imposed on viral replication by the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

7 January 2021

Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

7 January 2021

Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

7 January 2021

Selective Depletion of Liver and Splenic Macrophages Using Liposomes Encapsulating the Drug Dichloromethylene Diphosphonate: Effects on Antimicrobial Resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

7 January 2021

Macrophage subset repopulation in the spleen: differential kinetics after liposome-mediated elimination

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

7 January 2021

Depletion and repopulation of macrophages in spleen and liver of rat after intravenous treatment with liposome-encapsulated dichloromethylene diphosphonate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

7 January 2021

Kupffer cell elimination enhances development of liver schizonts of Plasmodium berghei in rats.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

7 January 2021

Ultrastructural and immunofluorescence studies of early events in adenovirus-HeLa cell interactions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

7 January 2021

Adenovirus Endocytosis via α v Integrins Requires Phosphoinositide-3-OH Kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

7 January 2021

Neutralization of adenoviruses: kinetics, stoichiometry, and mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

7 January 2021

Stepwise dismantling of adenovirus 2 during entry into cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

7 January 2021

Vitronectin receptor antibodies inhibit infection of HeLa and A549 cells by adenovirus type 12 but not by adenovirus type 2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

7 January 2021

Expression of alpha v beta 5 integrin is necessary for efficient adenovirus-mediated gene transfer in the human airway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

7 January 2021

Persistence of Replication-Deficient Adenovirus-Mediated Gene Transfer in Lungs of Immune-Deficient (nu/nu) Mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

7 January 2021

Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

7 January 2021

Use of transient CD4 lymphocyte depletion to prolong transgene expression of E1-deleted adenoviral vectors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

7 January 2021

Cytotoxic T-Lymphocyte Target Proteins and Their Major Histocompatibility Complex Class I Restriction in Response to Adenovirus Vectors Delivered to Mouse Liver

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3301424

7 January 2021

Identifiers

DOI

10.1038/SJ.GT.3301424

1 reference

Dimensions Publication ID

21 September 2017

1024265520

0 references

1 reference