(Q40609387)

22 September 2017

title

The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer (English)

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22 September 2017

Carl O Brown

1

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22 September 2017

Xuan Chi

2

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22 September 2017

Eduardo Garcia-Gras

3

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22 September 2017

Manabu Shirai

4

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22 September 2017

Xin-Hua Feng

5

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22 September 2017

Robert J Schwartz

6

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22 September 2017

language of work or name

English

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publication date

8 December 2003

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Journal of Biological Chemistry

22 September 2017

published in

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22 September 2017

volume

279

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22 September 2017

issue

11

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22 September 2017

page(s)

10659-10669

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NK-2 homeobox genes and heart development

22 September 2017

cites work

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Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, nkx-2.5.

21 January 2018

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Recruitment of the tinman homolog Nkx-2.5 by serum response factor activates cardiac alpha-actin gene transcription

21 January 2018

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GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression

21 January 2018

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Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation

21 January 2018

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Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis

21 January 2018

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The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression.

21 January 2018

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21 January 2018

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Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo

21 January 2018

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Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm

21 January 2018

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Bone morphogenetic proteins induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1 and cardiac transcription factors Csx/Nkx-2.5 and GATA-4

21 January 2018

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Smads, TAK1, and their common target ATF-2 play a critical role in cardiomyocyte differentiation.

21 January 2018

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21 January 2018

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OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways

21 January 2018

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21 January 2018

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21 January 2018

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Smads bind directly to the Jun family of AP-1 transcription factors

21 January 2018

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Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta

21 January 2018

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The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo

21 January 2018

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Smad2 role in mesoderm formation, left-right patterning and craniofacial development

21 January 2018

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Genetic analysis of the mammalian transforming growth factor-beta superfamily

21 January 2018

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Tempting fate: BMP signals for cardiac morphogenesis

21 January 2018

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Cardiac-specific activity of an Nkx2-5 enhancer requires an evolutionarily conserved Smad binding site

21 January 2018

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Nkx-2.5 gene induction in mice is mediated by a Smad consensus regulatory region.

21 January 2018

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Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B)

21 January 2018

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Dissecting long-range transcriptional mechanisms by chromatin immunoprecipitation

21 January 2018

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BMP signaling regulates Nkx2-5 activity during cardiomyogenesis

21 January 2018

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Cardiac and skeletal muscle development in P19 embryonal carcinoma cells

21 January 2018

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Physical and functional interaction between GATA-3 and Smad3 allows TGF-beta regulation of GATA target genes

21 January 2018

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Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer

21 January 2018

1 reference

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Interaction of Smad complexes with tripartite DNA-binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301648200

Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301648200

A (GATA)(7) motif located in the 5' boundary area of the human beta-globin locus control region exhibits silencer activity in erythroid cells

21 January 2018

1 reference

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The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301648200

Bone morphogenetic protein function is required for terminal differentiation of the heart but not for early expression of cardiac marker genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M301648200

21 January 2018

Identifiers

DOI

10.1074/JBC.M301648200

1 reference

22 September 2017

1 reference