(Q40612848)

English

Expression of cyclin E renders cyclin D-CDK4 dispensable for inactivation of the retinoblastoma tumor suppressor protein, activation of E2F, and G1-S phase progression

scientific article published on 25 November 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Expression of cyclin E renders cyclin D-CDK4 dispensable for inactivation of the retinoblastoma tumor suppressor protein, activation of E2F, and G1-S phase progression (English)

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

1 reference

based on heuristic

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author name string

Susan M Keenan

1

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Nathan H Lents

2

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Joseph J Baldassare

3

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

language of work or name

0 references

publication date

25 November 2003

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

279

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

5387-5396

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Regulation of cyclin-Cdk activity in mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Cancer cell cycles

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Ablation of Goalpha overrides G1 restriction point control through Ras/ERK/cyclin D1-CDK activities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

The retinoblastoma protein pathway and the restriction point

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

The retinoblastoma protein and cell cycle control

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Cyclin A and the retinoblastoma gene product complex with a common transcription factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

The E2F transcription factor is a cellular target for the RB protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

The regulation of E2F by pRB-family proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Differential regulation of retinoblastoma tumor suppressor protein by G(1) cyclin-dependent kinase complexes in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Retinoblastoma protein recruits histone deacetylase to repress transcription

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Retinoblastoma protein represses transcription by recruiting a histone deacetylase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Phosphorylation of the retinoblastoma protein by cdk2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Differential regulation of E2F transactivation by cyclin/cdk2 complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Cell cycle regulation of the murine cyclin E gene depends on an E2F binding site in the promoter.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Structure and cell cycle-regulated transcription of the human cyclin A gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

The E2F transcription factor activates a replication-dependent human H2A gene in early S phase of the cell cycle

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Human DNA polymerase alpha gene: sequences controlling expression in cycling and serum-stimulated cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Thymidine kinase transcription is regulated at G1/S phase by a complex that contains retinoblastoma-like protein and a cdc2 kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Transcription factor E2F is required for efficient expression of the hamster dihydrofolate reductase gene in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Regulation of the cyclin E gene by transcription factor E2F1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

The Rb family contains a conserved cyclin-dependent-kinase-regulated transcriptional repressor motif

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Rb-mediated chromatin structure regulation and transcriptional repression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Cyclin D1 provides a link between development and oncogenesis in the retina and breast

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Cyclin-dependent kinase 2 nucleocytoplasmic translocation is regulated by extracellular regulated kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Cells regulate their mitogenic response to thrombin through release of protease nexin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

RhoA stimulates p27(Kip) degradation through its regulation of cyclin E/CDK2 activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Distinct roles for cyclin-dependent kinases in cell cycle control

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

E2F: a link between the Rb tumor suppressor protein and viral oncoproteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Concurrent amplification of cyclin E and CDK2 genes in colorectal carcinomas

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Redundant cyclin overexpression and gene amplification in breast cancer cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Cyclin E and survival in patients with breast cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Cyclin-E is a strong predictor of endocrine therapy failure in human breast cancer.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Ectopic expression of cyclin E in estrogen responsive cells abrogates antiestrogen mediated growth arrest

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Induction of mammary gland hyperplasia and carcinomas in transgenic mice expressing human cyclin E

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Cyclin E ablation in the mouse

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Cdk2 knockout mice are viable

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

The oncogenic activity of cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Rescue of Cyclin D1 Deficiency by Knockin Cyclin E

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310383200

21 January 2018

Identifiers

10.1074/JBC.M310383200

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

ResearchGate publication ID

0 references

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