(Q40618475)

English

The use of in vitro metabolic stability for rapid selection of compounds in early discovery based on their expected hepatic extraction ratios

scientific article published on November 2002

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

The use of in vitro metabolic stability for rapid selection of compounds in early discovery based on their expected hepatic extraction ratios (English)

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

author name string

Yan Yi Lau

1

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Gopal Krishna

2

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Nathan P Yumibe

3

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Diane E Grotz

4

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Elpida Sapidou

5

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Laura Norton

6

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Inhou Chu

7

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Cliff Chen

8

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

A D Soares

9

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Chin-Chung Lin

10

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

publication date

1 November 2002

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Pharmaceutical Research

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

19

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

11

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

1606-1610

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

The use of human hepatocytes to select compounds based on their expected hepatic extraction ratios in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/12458665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the permeability characteristics of a human colonic epithelial (Caco-2) cell line to colon of rabbit, monkey, and dog intestine and human drug absorption

1 reference

https://pubmed.ncbi.nlm.nih.gov/12458665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug-protein binding sites. New trends in analytical and experimental methodology

1 reference

https://pubmed.ncbi.nlm.nih.gov/12458665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12458665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Permeability of lipophilic compounds in drug discovery using in-vitro human absorption model, Caco-2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12458665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/12458665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

1 reference

https://pubmed.ncbi.nlm.nih.gov/12458665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of hepatic extraction ratio from in vitro measurement of intrinsic clearance

1 reference

https://pubmed.ncbi.nlm.nih.gov/12458665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of hepatic metabolic clearance based on interspecies allometric scaling techniques and in vitro-in vivo correlations

1 reference

https://pubmed.ncbi.nlm.nih.gov/12458665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12458665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques

1 reference

https://pubmed.ncbi.nlm.nih.gov/12458665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of hepatic metabolic clearance: comparison and assessment of prediction models

1 reference

https://pubmed.ncbi.nlm.nih.gov/12458665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices

1 reference

https://pubmed.ncbi.nlm.nih.gov/12458665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12458665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integration of in vitro data into allometric scaling to predict hepatic metabolic clearance in man: application to 10 extensively metabolized drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/12458665

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1023/A:1020765025857

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q40618475&oldid=2099966836"