(Q40619186)

English

Apigenin Induces Apoptosis through Proteasomal Degradation of HER2/neu in HER2/neu-overexpressing Breast Cancer Cells via the Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

scientific article published on November 5, 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Apigenin induces apoptosis through proteasomal degradation of HER2/neu in HER2/neu-overexpressing breast cancer cells via the phosphatidylinositol 3-kinase/Akt-dependent pathway (English)

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Apigenin Induces Apoptosis through Proteasomal Degradation of HER2/neu in HER2/neu-overexpressing Breast Cancer Cells via the Phosphatidylinositol 3-Kinase/Akt-dependent Pathway (English)

1 reference

10.1074/JBC.M305529200

https://api.crossref.org/works/10.1074/JBC.M305529200

29 March 2024

1 reference

based on heuristic

inferred from title

1 reference

10.1074/JBC.M305529200

https://api.crossref.org/works/10.1074/JBC.M305529200

29 March 2024

1 reference

10.1074/JBC.M305529200

https://api.crossref.org/works/10.1074/JBC.M305529200

29 March 2024

author name string

Tzong-Der Way

1

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Ming-Ching Kao

2

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Jen-Kun Lin

3

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

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publication date

5 November 2003

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Europe PubMed Central

PubMed publication ID

22 September 2017

full work available at URL

http://www.jbc.org/content/279/6/4479.full.pdf

Portable Document Format

online access status

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14602723

29 March 2024

https://api.elsevier.com/content/article/PII:S0021925820750325?httpAccept=text/xml

1 reference

10.1074/JBC.M305529200

https://api.crossref.org/works/10.1074/JBC.M305529200

29 March 2024

https://api.elsevier.com/content/article/PII:S0021925820750325?httpAccept=text/plain

1 reference

10.1074/JBC.M305529200

https://api.crossref.org/works/10.1074/JBC.M305529200

29 March 2024

https://syndication.highwire.org/content/doi/10.1074/jbc.M305529200

1 reference

10.1074/JBC.M305529200

https://api.crossref.org/works/10.1074/JBC.M305529200

29 March 2024

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

279

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

4479-4489

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

International comparisons of mortality rates for cancer of the breast, ovary, prostate, and colon, and per capita food consumption

1 reference

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21 January 2018

Apigenin and tangeretin enhance gap junctional intercellular communication in rat liver epithelial cells

1 reference

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21 January 2018

Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes.

1 reference

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21 January 2018

Growth inhibitory effects of flavonoids in human thyroid cancer cell lines

1 reference

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21 January 2018

Height and breast cancer risk--the bias of self-reported versus measured results. Comments on height and breast cancer risk, Tavani et al., Eur J Cancer 1998, 34, 543-547.

1 reference

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21 January 2018

Involvement of nuclear factor-kappa B, Bax and Bcl-2 in induction of cell cycle arrest and apoptosis by apigenin in human prostate carcinoma cells

1 reference

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21 January 2018

Inhibition of protein-tyrosine kinase activity by flavanoids and related compounds

1 reference

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21 January 2018

Inhibitions of protein kinase C and proto-oncogene expressions in NIH 3T3 cells by apigenin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305529200

21 January 2018

Cancer statistics, 2001

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305529200

21 January 2018

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305529200

21 January 2018

Role of HER2 gene overexpression in breast carcinoma

1 reference

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21 January 2018

The ErbB signaling network: receptor heterodimerization in development and cancer

1 reference

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21 January 2018

Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305529200

21 January 2018

Downstream signalling events regulated by phosphatidylinositol 3-kinase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305529200

21 January 2018

Heregulin-dependent activation of phosphoinositide 3-kinase and Akt via the ErbB2/ErbB3 co-receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305529200

21 January 2018

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305529200

21 January 2018

Regulation of cell death protease caspase-9 by phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305529200

21 January 2018

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305529200

21 January 2018

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305529200

21 January 2018

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305529200

21 January 2018

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

1 reference

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21 January 2018

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

1 reference

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21 January 2018

Inhibition of tumor growth by a monoclonal antibody reactive with an oncogene-encoded tumor antigen

1 reference

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21 January 2018

Development of anti-p185HER2 immunoliposomes for cancer therapy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305529200

21 January 2018

Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305529200

21 January 2018

Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: a comparison with tyrosine kinase and protein kinase C inhibition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305529200

21 January 2018

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

1 reference

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21 January 2018

The PI3K-PDK1 connection: more than just a road to PKB

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305529200

21 January 2018

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305529200

21 January 2018

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305529200

21 January 2018

ErbB3 (HER3) interaction with the p85 regulatory subunit of phosphoinositide 3-kinase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305529200

21 January 2018

Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305529200

21 January 2018

Apigenin acts on the tumor cell invasion process and regulates protease production

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305529200

21 January 2018

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305529200

21 January 2018

Expression of the ERBB3 gene product in breast cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305529200

21 January 2018

Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer

1 reference

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21 January 2018

Effects of oncogenic ErbB2 on G1 cell cycle regulators in breast tumour cells

1 reference

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21 January 2018

Tyrosine kinase inhibition: an approach to drug development

1 reference

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21 January 2018

p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.

1 reference

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21 January 2018

Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90

1 reference

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21 January 2018

Lipid-Regulated Kinases: Some Common Themes at Last

1 reference

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21 January 2018

Genotoxicities of nitropyrenes and their modulation by apigenin, tannic acid, ellagic acid and indole-3-carbinol in the Salmonella and CHO systems.

2

1 reference

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29 March 2024

Plant-derived phenolic antioxidants

6

1 reference

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29 March 2024

Phytoestrogen concentration determines effects on DNA synthesis in human breast cancer cells

7

1 reference

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29 March 2024

Flavonoids apigenin and quercetin inhibit melanoma growth and metastatic potential

10

1 reference

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29 March 2024

Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells

12

1 reference

10.1074/JBC.M305529200

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29 March 2024

Cancer Research

20

54

3150

author name string

Yu

publication date

1994

1 reference

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29 March 2024

Low metastatic potential of clone from murine colon adenocarcinoma 26 increased by transfection of activated c-erbB-2 gene

21

1 reference

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29 March 2024

Prevention of breast tumour development in vivo by downregulation of the p185neureceptor

41

1 reference

10.1074/JBC.M305529200

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29 March 2024

Cancer Research

44

52

2771

author name string

Kasprzyk

publication date

1992

1 reference

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29 March 2024

Cancer Research

57

60

5303

author name string

Nakashio

publication date

2000

1 reference

10.1074/JBC.M305529200

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29 March 2024

Expression of the type 1 tyrosine kinase growth factor receptors EGF receptor, c-erbB2 and c-erbB3 in bladder cancer

60

1 reference

10.1074/JBC.M305529200

https://api.crossref.org/works/10.1074/JBC.M305529200

29 March 2024

Cancer Research

67

55

3890

author name string

Zhang

publication date

1995

1 reference

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29 March 2024

Tyrphostins: tyrosine kinase blockers as novel antiproliferative agents and dissectors of signal transduction

68

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29 March 2024

Identifiers

10.1074/JBC.M305529200

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

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