(Q40620999)

22 September 2017

Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPalpha expression (English)

1 reference

22 September 2017

Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBPα expression (English)

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

27 March 2024

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

27 March 2024

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

27 March 2024

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

27 March 2024

author name string

Rui Zheng

1

1 reference

22 September 2017

Mark Levis

3

1 reference

22 September 2017

Li Li

4

1 reference

22 September 2017

Donald Small

6

1 reference

22 September 2017

Alan D. Friedman

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14592841

27 March 2024

Edward G. Weir

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14592841

27 March 2024

language of work or name

English

0 references

publication date

30 October 2003

1 reference

full work available at URL

22 September 2017

8

1 reference

based on heuristic

inferred from page(s)

published in

Blood

1 reference

22 September 2017

103

1 reference

22 September 2017

5

1 reference

22 September 2017

1883-1890

1 reference

The roles of FLT3 in hematopoiesis and leukemia

22 September 2017

2

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines

27 March 2024

4

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

27 March 2024

5

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia

27 March 2024

6

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product

27 March 2024

7

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

Constitutive activation of FLT3 in acute myeloid leukaemia and its consequences for growth of 32D cells

27 March 2024

8

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia. The Children's Cancer and Leukemia Study Group, Japan

27 March 2024

9

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

27 March 2024

11

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations

27 March 2024

13

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

Transcriptional regulation of granulocyte and monocyte development

27 March 2024

14

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice

27 March 2024

16

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

CCAAT/enhancer binding protein alpha is a regulatory switch sufficient for induction of granulocytic development from bipotential myeloid progenitors

27 March 2024

17

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia

27 March 2024

19

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene

27 March 2024

20

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

C/EBP, c-Myb, and PU.1 cooperate to regulate the neutrophil elastase promoter

27 March 2024

22

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

Temporal mapping of gene expression levels during the differentiation of individual primary hematopoietic cells

27 March 2024

23

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.

27 March 2024

24

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

Heterozygous PU.1 mutations are associated with acute myeloid leukemia.

27 March 2024

26

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

Cross-talk between regulators of myeloid development: C/EBPalpha binds and activates the promoter of the PU.1 gene

27 March 2024

27

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

27 March 2024

28

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo

27 March 2024

29

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

CCAAT-enhancer binding protein: a component of a differentiation switch

27 March 2024

32

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia. Leukemia Study Group of the Ministry of Health and Welfare (Kohseisho)

27 March 2024

33

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

Molecular evolution of acute myeloid leukaemia in relapse: unstable N-ras and FLT3 genes compared with p53 gene.

27 March 2024

34

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

27 March 2024

35

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice

27 March 2024

38

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model

27 March 2024

39

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

Induction of C/EBPalpha activity alters gene expression and differentiation of human CD34+ cells.

27 March 2024

40

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes

27 March 2024

41

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

High level activity of the mouse CCAAT/enhancer binding protein (C/EBP alpha) gene promoter involves autoregulation and several ubiquitous transcription factors

27 March 2024

42

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

BCR-ABL suppresses C/EBPalpha expression through inhibitory action of hnRNP E2.

27 March 2024

43

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells

27 March 2024

44

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

Inhibition of cell proliferation by C/EBP alpha occurs in many cell types, does not require the presence of p53 or Rb, and is not affected by large T-antigen

27 March 2024

45

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia

27 March 2024

46

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha

27 March 2024

47

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha

27 March 2024

48

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2003-06-1978

27 March 2024

Identifiers

1 reference

22 September 2017

1 reference