(Q40621243)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12437122%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

title

Trypsin mutants for structure-based drug design: expression, refolding and crystallisation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12437122%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

1 reference

1

1 reference

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15 December 2019

Milton T Stubbs

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12437122%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

author name string

Sabine Reyda

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12437122%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

Gerhard Klebe

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12437122%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

publication date

1 July 2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12437122%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12437122%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

volume

383

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12437122%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

issue

7-8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12437122%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

page(s)

1309-1314

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12437122%20AND%20SRC:MED&resulttype=core&format=json

X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition

15 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

The coagulation cascade: initiation, maintenance, and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

Hydrophobic interactions control zymogen activation in the trypsin family of serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

An integrated approach to structural genomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

High-throughput three-dimensional protein structure determination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

Structural genomics for science and society.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

Improved methods for building protein models in electron density maps and the location of errors in these models

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

Exploiting subsite S1 of trypsin-like serine proteases for selectivity: potent and selective inhibitors of urokinase-type plasminogen activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

Crystal structures of human factor Xa complexed with potent inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

Kinetics of papain-catalyzed hydrolysis of -N-benzoyl-L-arginine-p-nitroanilide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

Structural basis for inhibition promiscuity of dual specific thrombin and factor Xa blood coagulation inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

Structure-directed discovery of potent non-peptidic inhibitors of human urokinase that access a novel binding subsite.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

Structure of human des(1-45) factor Xa at 2.2 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

High-level bacterial expression and 15N-alanine-labeling of bovine trypsin. Application to the study of trypsin-inhibitor complexes and trypsinogen activation by NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enz

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

Structural and functional analyses of benzamidine-based inhibitors in complex with trypsin: implications for the inhibition of factor Xa, tPA, and urokinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

Protein structure modeling for structural genomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

Docking ligands onto binding site representations derived from proteins built by homology modelling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

(Z,Z)-2,7-Bis(4-amidinobenzylidene)cycloheptan-1-one: identification of a highly active inhibitor of blood coagulation factor Xa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

Urethanyl-3-amidinophenylalanine derivatives as inhibitors of factor Xa. X-ray crystal structure of a trypsin/inhibitor complex and modeling studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

(4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

A player of many parts: the spotlight falls on thrombin's structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

Crystal structures of factor Xa specific inhibitors in complex with trypsin: structural grounds for inhibition of factor Xa and selectivity against thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

pH-dependent binding modes observed in trypsin crystals: lessons for structure-based drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2002.148

21 January 2018

Identifiers

DOI

10.1515/BC.2002.148

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12437122%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

1 reference