(Q40623520)

22 September 2017

title

AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression (English)

1 reference

22 September 2017

1 reference

Joseph F Gera

1

1 reference

22 September 2017

Ingo K Mellinghoff

2

1 reference

22 September 2017

Yijiang Shi

3

1 reference

22 September 2017

Matthew B Rettig

4

1 reference

22 September 2017

Chris Tran

5

1 reference

22 September 2017

Jung-hsin Hsu

6

1 reference

22 September 2017

Charles L Sawyers

7

1 reference

22 September 2017

Alan K Lichtenstein

8

1 reference

22 September 2017

language of work or name

English

0 references

publication date

23 October 2003

1 reference

Journal of Biological Chemistry

22 September 2017

published in

1 reference

22 September 2017

volume

279

1 reference

22 September 2017

issue

4

1 reference

22 September 2017

page(s)

2737-2746

1 reference

Identification of TOR signaling complexes: more TORC for the cell growth engine

22 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

Mammalian TOR: a homeostatic ATP sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

Regulation of translation initiation by FRAP/mTOR

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

Tor signalling in bugs, brain and brawn

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

TOR signalling and control of cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

The AKT kinase is activated in multiple myeloma tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

Messenger RNA translation state: the second dimension of high-throughput expression screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

Control of cyclin-dependent kinase inhibitor p27 expression by cap-independent translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

TOR controls translation initiation and early G1 progression in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

Evidence that cyclin D1 mediates both growth and proliferation downstream of TOR in hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

C-Myc 5' untranslated region contains an internal ribosome entry segment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

Analysis of the c-myc IRES; a potential role for cell-type specific trans-acting factors and the nuclear compartment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

Derivation of a structural model for the c-myc IRES

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

The ribosome filter hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

Irresistible IRES. Attracting the translation machinery to internal ribosome entry sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

Role of translation initiation factor 2B in control of cell survival by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309999200

21 January 2018

Identifiers

DOI

10.1074/JBC.M309999200

1 reference

22 September 2017

1 reference