(Q40627442)

English

Mutations in the lipid-binding domain of α-synuclein confer overlapping, yet distinct, functional properties in the regulation of dopamine transporter activity

scientific article published on September 1, 2003

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scholarly article

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Europe PubMed Central

PubMed publication ID

22 September 2017

Mutations in the lipid-binding domain of alpha-synuclein confer overlapping, yet distinct, functional properties in the regulation of dopamine transporter activity (English)

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Mutations in the lipid-binding domain of α-synuclein confer overlapping, yet distinct, functional properties in the regulation of dopamine transporter activity (English)

1 reference

10.1016/S1044-7431(03)00124-6

https://api.crossref.org/works/10.1016/S1044-7431(03)00124-6

20 March 2024

1 reference

based on heuristic

inferred from title

membrane glycoprotein

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14550771

20 March 2024

1 reference

10.1016/S1044-7431(03)00124-6

https://api.crossref.org/works/10.1016/S1044-7431(03)00124-6

20 March 2024

author name string

Christophe Wersinger

1

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Delphine Prou

2

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Philippe Vernier

3

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Anita Sidhu

5

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Hyman B. Niznik

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14550771

20 March 2024

language of work or name

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=14550771

20 March 2024

publication date

1 September 2003

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

full work available at URL

https://api.elsevier.com/content/article/PII:S1044743103001246?httpAccept=text/xml

1 reference

10.1016/S1044-7431(03)00124-6

https://api.crossref.org/works/10.1016/S1044-7431(03)00124-6

20 March 2024

https://api.elsevier.com/content/article/PII:S1044743103001246?httpAccept=text/plain

1 reference

10.1016/S1044-7431(03)00124-6

https://api.crossref.org/works/10.1016/S1044-7431(03)00124-6

20 March 2024

Molecular and Cellular Neuroscience

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

24

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

91-105

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Absence of mutations in the coding region of the alpha-synuclein gene in pathologically proven Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

A broken alpha -helix in folded alpha -Synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Review: formation and properties of amyloid-like fibrils derived from alpha-synuclein and related proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Conformational properties of alpha-synuclein in its free and lipid-associated states

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Multiple-system atrophy: a new alpha-synuclein disease?

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Lewy body diseases and multiple system atrophy as alpha-synucleinopathies

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Filamentous nerve cell inclusions in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Postnatal expression of alpha-synuclein protein in the rodent substantia nigra and striatum

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

alpha-Synuclein membrane interactions and lipid specificity

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Human alpha-synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Dopaminergic cell loss induced by human A30P alpha-synuclein gene transfer to the rat substantia nigra

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of cytoplasmic alpha-synuclein aggregates. Fibril formation is tightly linked to the inclusion-forming process in cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential localization of alpha-, beta- and gamma-synucleins in the rat CNS

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Antibodies to alpha-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Measurement of cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Recent advances in the genetics and pathogenesis of Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction of alpha-synuclein aggregation by intracellular nitrative insult.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Multiple coupling of human D5 dopamine receptors to guanine nucleotide binding proteins Gs and Gz

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Alpha-synuclein in Lewy bodies

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Fatal attractions: abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Aggregation of neurofilament and alpha-synuclein proteins in Lewy bodies: implications for the pathogenesis of Parkinson disease and Lewy body dementia

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Neuropathology in mice expressing human alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Synphilin-1 is present in Lewy bodies in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential cytotoxicity of dopamine and H2O2 in a human neuroblastoma divided cell line transfected with α-synuclein and its familial Parkinson's disease-linked mutants

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Attenuation of dopamine transporter activity by alpha-synuclein

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Overexpression of human alpha-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Overexpression of human alpha-synuclein causes dopamine neuron death in primary human mesencephalic culture

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Lipid binding inhibits alpha-synuclein fibril formation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-7431%2803%2900124-6

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S1044-7431(03)00124-6

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

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