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A novel rationale for inhibition of gelatinase B in multiple sclerosis: MMP-9 destroys alpha B-crystallin and generates a promiscuous T cell epitope.
scientific article published on August 2003
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12965253
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12965253%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
title
A novel rationale for inhibition of gelatinase B in multiple sclerosis: MMP-9 destroys alpha B-crystallin and generates a promiscuous T cell epitope
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12965253
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12965253%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
main subject
multiple sclerosis
0 references
author
Johannes M van Noort
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12965253
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12965253%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
Philippe E Van den Steen
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12965253
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12965253%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
Ghislain Opdenakker
series ordinal
5
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12965253
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12965253%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
author name string
Sofie Starckx
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12965253
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12965253%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
Richard Verbeek
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12965253
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12965253%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
language of work or name
English
1 reference
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publication date
1 August 2003
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12965253
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12965253%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
number of pages
11
1 reference
based on heuristic
inferred from page(s)
published in
Journal of Neuroimmunology
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12965253
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12965253%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
volume
141
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12965253
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12965253%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
issue
1-2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12965253
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12965253%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
page(s)
47-57
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12965253
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12965253%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
cites work
Matrix metalloproteinase expression in an experimentally-induced DTH model of multiple sclerosis in the rat CNS.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of αB-crystallin in glia cells during lesional development in multiple sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Presentation of alpha B-crystallin to T cells in active multiple sclerosis lesions: an early event following inflammatory demyelination
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The degenerative effect of a single intranigral injection of LPS on the dopaminergic system is prevented by dexamethasone, and not mimicked by rh-TNF-alpha, IL-1beta and IFN-gamma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Small heat-shock proteins and their potential role in human disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Plasminogen activators and matrix metalloproteases, mediators of extracellular proteolysis in inflammatory demyelination of the central nervous system.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Expression of Tissue-type Plasminogen Activator, Matrix Metalloproteases and Endogenous Inhibitors in the Central Nervous System in Multiple Sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Analysis of Gelatinases in Complex Biological Fluids and Tissue Extracts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Gelatinase B is diabetogenic in acute and chronic pancreatitis by cleaving insulin.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Resistance of young gelatinase B-deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The heat shock response reduces myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in mice.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ancrod
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Matrix metalloproteinases in the normal human central nervous system, microglial nodules, and multiple sclerosis lesions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human hepatoma cells produce an 85 kDa gelatinase regulated by phorbol 12-myristate 13-acetate.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stromelysin-1 and gelatinase A are upregulated before TNF-alpha in LPS-stimulated neuroinflammation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytokine-regulated proteases in autoimmune diseases.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evaluation of gelatinases and IL-6 in the cerebrospinal fluid of patients with optic neuritis, multiple sclerosis and other inflammatory neurological diseases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Monoclonal Antibodies Specific for Natural Human Neutrophil Gelatinase B Used for Affinity Purification, Quantitation by Two-Site ELISA and Inhibition of Enzymatic Activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Leukocyte Gelatinase B Cleavage Releases Encephalitogens from Human Myelin Basic Protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Matrix metalloproteinases in neuroinflammation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Encephalitogenic and immunogenic potential of the stress protein alphaB-crystallin in Biozzi ABH (H-2A(g7)) mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cleavage of denatured natural collagen type II by neutrophil gelatinase B reveals enzyme specificity, post-translational modifications in the substrate, and the formation of remnant epitopes in rheumatoid arthritis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Do heat shock proteins control the balance of T-cell regulation in inflammatory diseases?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HSP70 protects against TNF-induced lethal inflammatory shock.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The small heat-shock protein αB-crystallin as candidate autoantigen in multiple sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T cells discriminate between differentially phosphorylated forms of alphaB-crystallin, a major central nervous system myelin antigen
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tolerance controls encephalitogenicity of alphaB-crystallin in the Lewis rat
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
T- and B-cell nonresponsiveness to self-alphaB-crystallin in SJL mice prevents the induction of experimental allergic encephalomyelitis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of heat shock proteins in protection from and pathogenesis of infectious diseases.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0165-5728%2803%2900217-0
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0165-5728(03)00217-0
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12965253
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12965253%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
PubMed publication ID
12965253
1 reference
stated in
Europe PubMed Central
PubMed publication ID
12965253
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12965253%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 November 2019
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