(Q40637233)

22 September 2017

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title

The MAP kinase cascade. Discovery of a new signal transduction pathway (English)

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22 September 2017

Ahn NG

1

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22 September 2017

publication date

1 November 1993

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Molecular and Cellular Biochemistry

22 September 2017

published in

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22 September 2017

volume

127-128

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22 September 2017

page(s)

201-209

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https://scigraph.springernature.com/pub.10.1007/bf01076771

22 September 2017

exact match

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cites work

Evidence for one or more Raf-1 kinase kinase(s) activated by insulin and polypeptide growth factors

1 reference

12 December 2020

Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro

1 reference

12 December 2020

Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein

1 reference

12 December 2020

Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells

1 reference

12 December 2020

Multiple phosphorylation of ribosomal protein S6 during transition of quiescent 3T3 cells into early G1, and cellular compartmentalization of the phosphate donor

1 reference

12 December 2020

Meiotic initiation by the mos protein in Xenopus

1 reference

12 December 2020

Activation of S6 kinase activity in 3T3-L1 cells by insulin and phorbol ester

1 reference

12 December 2020

Evidence for an epidermal growth factor-stimulated protein kinase cascade in Swiss 3T3 cells. Activation of serine peptide kinase activity by myelin basic protein kinases in vitro

1 reference

12 December 2020

Increased phosphorylation of ribosomal protein S6 during meiotic maturation of Xenopus oocytes

1 reference

12 December 2020

Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro

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12 December 2020

Raf-1 is a potential substrate for mitogen-activated protein kinase in vivo

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12 December 2020

Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro

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12 December 2020

In vivo phosphorylation and activation of ribosomal protein S6 kinases during Xenopus oocyte maturation

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12 December 2020

Ordered multisite phosphorylation of Xenopus ribosomal protein S6 by S6 kinase II

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12 December 2020

Mouse Erk-1 gene product is a serine/threonine protein kinase that has the potential to phosphorylate tyrosine

1 reference

12 December 2020

Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

1 reference

12 December 2020

Purification and characterization of a protein kinase from Xenopus eggs highly specific for ribosomal protein S6

1 reference

12 December 2020

Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a myelin basic protein/microtubule-associated protein 2 kinase

1 reference

12 December 2020

Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo

1 reference

12 December 2020

Effect of experimental diabetes and insulin on phosphorylation of rat liver ribosomal protein S6

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12 December 2020

An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control

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12 December 2020

Activation of the MAP kinase pathway by the protein kinase raf

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12 December 2020

Immunological characterization of avian MAP kinases: evidence for nuclear localization

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12 December 2020

The phorbol ester-dependent activator of the mitogen-activated protein kinase p42mapk is a kinase with specificity for the threonine and tyrosine regulatory sites

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12 December 2020

Substrate specificity of ribosomal protein S6 kinase II from Xenopus eggs

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12 December 2020

Growth factor-induced activation of a kinase activity which causes regulatory phosphorylation of p42/microtubule-associated protein kinase

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12 December 2020

Activation of myelin basic protein kinases during echinoderm oocyte maturation and egg fertilization

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12 December 2020

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.

1 reference

12 December 2020

Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product

1 reference

12 December 2020

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)

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12 December 2020

A protein factor for ras p21-dependent activation of mitogen-activated protein (MAP) kinase through MAP kinase kinase

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12 December 2020

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1 reference

12 December 2020

Identification of multiple epidermal growth factor-stimulated protein serine/threonine kinases from Swiss 3T3 cells

1 reference

12 December 2020

The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product

1 reference

12 December 2020

Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

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12 December 2020

Purification of a hepatic S6 kinase from cycloheximide-treated Rats

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12 December 2020

cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates

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12 December 2020

Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies

1 reference

12 December 2020

byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype

1 reference

12 December 2020

Identification of Xenopus S6 protein kinase homologs (pp90rsk) in somatic cells: phosphorylation and activation during initiation of cell proliferation

1 reference

12 December 2020

Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase

1 reference

12 December 2020

Activation of a Ca2+-inhibitable protein kinase that phosphorylates microtubule-associated protein 2 in vitro by growth factors, phorbol esters, and serum in quiescent cultured human fibroblasts

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12 December 2020

Involvement of p21ras in activation of extracellular signal-regulated kinase 2.

1 reference

12 December 2020

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

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12 December 2020

S6 kinase in quiescent Swiss mouse 3T3 cells is activated by phosphorylation in response to serum treatment

1 reference

12 December 2020

Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase

1 reference

12 December 2020

Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase

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12 December 2020

Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation

1 reference

12 December 2020

1 reference

12 December 2020

An insulin-stimulated ribosomal protein S6 kinase from rabbit liver

1 reference

12 December 2020

The mitogen-activated protein kinase activator

1 reference

12 December 2020

Purification and characterization of a 40 S ribosomal protein S6 kinase from vanadate-stimulated Swiss 3T3 cells

1 reference

12 December 2020

Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase

1 reference

12 December 2020

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

1 reference

12 December 2020

Raf-1: A kinase currently without a cause but not lacking in effects

1 reference

12 December 2020

A conserved kinase cascade for MAP kinase activation in yeast.

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12 December 2020

Activation of mitogen-activated protein kinase and its activator by ras in intact cells and in a cell-free system

1 reference

12 December 2020

Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms

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12 December 2020

Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily

1 reference

12 December 2020

Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases

1 reference

12 December 2020

MAP kinase activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinase

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12 December 2020

Structure, expression, and regulation of protein kinases involved in the phosphorylation of ribosomal protein S6.

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12 December 2020

Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro

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12 December 2020

Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin

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12 December 2020

MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase

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12 December 2020

Nucleotide sequence of the yeast regulatory gene STE7 predicts a protein homologous to protein kinases

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12 December 2020

Purification and characterization of ribosomal protein S6 kinase I from Xenopus eggs.

1 reference

12 December 2020

Substrate recognition determinants of the mitogen-activated 70K S6 kinase from rat liver

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12 December 2020

Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

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12 December 2020

p21ras-induced meiotic maturation of Xenopus oocytes in the absence of protein synthesis: MPF activation is preceded by activation of MAP and S6 kinases.

1 reference

12 December 2020

Pheromone-induced signal transduction in Saccharomyces cerevisiae requires the sequential function of three protein kinases.

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12 December 2020

Colony stimulating factor-1 (CSF-1) stimulates temperature dependent phosphorylation and activation of the RAF-1 proto-oncogene product

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12 December 2020

Raf-1 activates MAP kinase-kinase

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12 December 2020

Nuclear localization and regulation of erk- and rsk-encoded protein kinases

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12 December 2020

Stimulation of mitogen-activated protein kinase by oncogenic Ras p21 in Xenopus oocytes. Requirement for Ras p21-GTPase-activating protein interaction.

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12 December 2020

Phosphorylation of Xenopus mitogen-activated protein (MAP) kinase kinase by MAP kinase kinase kinase and MAP kinase.

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12 December 2020

Xenopus MAP kinase activator: identification and function as a key intermediate in the phosphorylation cascade

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12 December 2020

ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1 reference

12 December 2020

Complete nucleotide sequence of a gene conferring polymyxin B resistance on yeast: similarity of the predicted polypeptide to protein kinases

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12 December 2020

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

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12 December 2020

Metabolic labeling of mitogen-activated protein kinase kinase in A431 cells demonstrates phosphorylation on serine and threonine residues

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12 December 2020

Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes

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12 December 2020

Protein phosphatase 2A inactivates the mitogen-stimulated S6 kinase from Swiss mouse 3T3 cells.

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12 December 2020

Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1

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12 December 2020

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

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12 December 2020

Activation of multiple protein kinases during the burst in protein phosphorylation that precedes the first meiotic cell division in Xenopus oocytes

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12 December 2020

Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity

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12 December 2020

Evidence that extracellular signal-regulated kinases are the insulin-activated Raf-1 kinase kinases

1 reference

12 December 2020

The wis1 protein kinase is a dosage-dependent regulator of mitosis in Schizosaccharomyces pombe

1 reference

12 December 2020

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

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12 December 2020

Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade

1 reference

12 December 2020

The amino acid sequence of a mammalian MAP kinase kinase

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12 December 2020

Epidermal growth factor-mediated activation of an S6 kinase in Swiss mouse 3T3 cells.

1 reference

12 December 2020

A Xenopus ribosomal protein S6 kinase has two apparent kinase domains that are each similar to distinct protein kinases

1 reference

12 December 2020

Requirements for Phosphorylation of Map Kinase During Meiosis in Xenopus Oocytes

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12 December 2020

An insulin-stimulated ribosomal protein S6 kinase in 3T3-L1 cells

1 reference

12 December 2020

A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf

1 reference

12 December 2020

Early events in insulin actions

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12 December 2020

MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways

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12 December 2020

Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes

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12 December 2020

Phosphorylation of c-jun mediated by MAP kinases.

1 reference

12 December 2020

A gene which encodes a predicted protein kinase can restore some functions of the ras gene in fission yeast.

1 reference

12 December 2020

ERKs, extracellular signal-regulated MAP-2 kinases

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12 December 2020

Xenopus oocytes and the biochemistry of cell division

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12 December 2020

Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation

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12 December 2020

Dual-specificity protein kinases: will any hydroxyl do?

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12 December 2020

Autophosphorylation in vitro of recombinant 42-kilodalton mitogen-activated protein kinase on tyrosine

1 reference

12 December 2020

Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase

1 reference

12 December 2020

The phosphorylation of liver ribosomal proteins in vivo. Evidence that only a single small subunit protein (S6) is phosphorylated

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF01076771

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22 September 2017

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