(Q40637880)

22 September 2017

Identification of residues and domains of Raf important for function in vivo and in vitro (English)

1 reference

22 September 2017

Angus Harding

1

1 reference

22 September 2017

Virginia Hsu

series ordinal

2

1 reference

22 September 2017

Kerry Kornfeld

series ordinal

3

1 reference

22 September 2017

John F Hancock

series ordinal

4

1 reference

22 September 2017

language of work or name

English

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publication date

3 September 2003

1 reference

Journal of Biological Chemistry

22 September 2017

1 reference

22 September 2017

278

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22 September 2017

46

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22 September 2017

45519-45527

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Raf functions downstream of Ras1 in the Sevenless signal transduction pathway

22 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

MEK-1 phosphorylation by MEK kinase, Raf, and mitogen-activated protein kinase: analysis of phosphopeptides and regulation of activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Mutational activation of c-raf-1 and definition of the minimal transforming sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Definition of the human raf amino-terminal regulatory region by deletion mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Ras-Raf complexes: analyses of complexes formed in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Activation of Raf as a result of recruitment to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Mammalian Ras interacts directly with the serine/threonine kinase Raf

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

p50(cdc37) binds directly to the catalytic domain of Raf as well as to a site on hsp90 that is topologically adjacent to the tetratricopeptide repeat binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Disruption of Raf-1/heat shock protein 90 complex and Raf signaling by dexamethasone in mast cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Interactions of c-Raf-1 with phosphatidylserine and 14-3-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Usage of tautomycetin, a novel inhibitor of protein phosphatase 1 (PP1), reveals that PP1 is a positive regulator of Raf-1 in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

14-3-3 facilitates Ras-dependent Raf-1 activation in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

MEK kinase activity is not necessary for Raf-1 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Endothelial apoptosis in Braf-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Craf-1 protein kinase is essential for mouse development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Ras is required for a limited number of cell fates and not for general proliferation in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Plasma membrane-targeted ras GTPase-activating protein is a potent suppressor of p21ras function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Positive and negative regulation of Raf kinase activity and function by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Activation loop phosphorylation and catalysis in protein kinases: is there functional evidence for the autoinhibitor model?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

14-3-3 proteins are required for maintenance of Raf-1 phosphorylation and kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

The complexity of Raf-1 regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Signal transduction: hanging on a scaffold.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

SIGNAL TRANSDUCTION:Routing MAP Kinase Cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

Activity of plasma membrane-recruited Raf-1 is regulated by Ras via the Raf zinc finger

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303106200

21 January 2018

Identifiers

DOI

10.1074/JBC.M303106200

1 reference

22 September 2017

1 reference