(Q40643213)

English

Phosphorylation of initiation factor 4E is resistant to SB203580 in cells expressing a drug-resistant mutant of stress-activated protein kinase 2a/p38.

scientific article published on August 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Phosphorylation of initiation factor 4E is resistant to SB203580 in cells expressing a drug-resistant mutant of stress-activated protein kinase 2a/p38. (English)

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

phosphorylation

1 reference

based on heuristic

inferred from title

author name string

Simon J Morley

1

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Susanne Naegele

2

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

publication date

1 August 2003

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

number of pages

9

1 reference

based on heuristic

inferred from page(s)

Cellular Signalling

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

15

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

741-749

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Signal transduction pathways that regulate eukaryotic protein synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structures of 7-methylguanosine 5'-triphosphate (m(7)GTP)- and P(1)-7-methylguanosine-P(3)-adenosine-5',5'-triphosphate (m(7)GpppA)-bound human full-length eukaryotic initiation factor 4E: biological importance of the C-terminal flexible reg

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

A tale of two termini: a functional interaction between the termini of an mRNA is a prerequisite for efficient translation initiation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Circularization of mRNA by eukaryotic translation initiation factors

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

eIF4G dramatically enhances the binding of eIF4E to the mRNA 5'-cap structure

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of eukaryotic protein synthesis initiation factor 4E at Ser-209

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Serine 209, not serine 53, is the major site of phosphorylation in initiation factor eIF-4E in serum-treated Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Chromatographic resolution of in vivo phosphorylated and nonphosphorylated eukaryotic translation initiation factor eIF-4E: increased cap affinity of the phosphorylated form

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Signalling through either the p38 or ERK mitogen-activated protein (MAP) kinase pathway is obligatory for phorbol ester and T cell receptor complex (TCR-CD3)-stimulated phosphorylation of initiation factor (eIF) 4E in Jurkat T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Involvement of stress-activated protein kinase and p38/RK mitogen-activated protein kinase signaling pathways in the enhanced phosphorylation of initiation factor 4E in NIH 3T3 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of eukaryotic initiation factor 4E (eIF4E) at Ser209 is not required for protein synthesis in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of eukaryotic initiation factor (eIF) 4E is not required for de novo protein synthesis following recovery from hypertonic stress in human kidney cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of the cap-binding protein eIF4E by the MAPK-activated protein kinase Mnk1.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Eukaryotic translation initiation factor 4E (eIF4E) binding site and the middle one-third of eIF4GI constitute the core domain for cap-dependent translation, and the C-terminal one-third functions as a modulatory region

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Use of a drug-resistant mutant of stress-activated protein kinase 2a/p38 to validate the in vivo specificity of SB 203580.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activate

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2803%2900008-1

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0898-6568(03)00008-1

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

release_3feqoke3v5deba5nffh2t746vm

1 reference

https://api.fatcat.wiki/v0/release/3feqoke3v5deba5nffh2t746vm

24 November 2022

based on heuristic

mapped directly with Wikidata item

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

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