(Q40653038)

22 September 2017

title

Identification of the Antineoplastic Agent 6-Mercaptopurine as an Activator of the Orphan Nuclear Hormone Receptor Nurr1 (English)

1 reference

https://api.crossref.org/works/10.1074/JBC.M302167200

26 December 2023

1 reference

1 reference

https://api.crossref.org/works/10.1074/JBC.M302167200

26 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M302167200

26 December 2023

author name string

Peter Ordentlich

1

1 reference

22 September 2017

Yingzhuo Yan

2

1 reference

22 September 2017

Sihong Zhou

3

1 reference

22 September 2017

Richard A. Heyman

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12709433

26 December 2023

language of work or name

English

0 references

publication date

22 April 2003

1 reference

full work available at URL

22 September 2017

http://www.jbc.org/article/S0021925820869373/pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12709433

https://api.elsevier.com/content/article/PII:S0021925820869373?httpAccept=text/xml

26 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M302167200

https://api.elsevier.com/content/article/PII:S0021925820869373?httpAccept=text/plain

26 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M302167200

https://syndication.highwire.org/content/doi/10.1074/jbc.M302167200

26 December 2023

1 reference

https://api.crossref.org/works/10.1074/JBC.M302167200

Journal of Biological Chemistry

26 December 2023

published in

1 reference

22 September 2017

volume

278

1 reference

22 September 2017

issue

27

1 reference

22 September 2017

page(s)

24791-24799

1 reference

Studies on Condensed Pyrimidine Systems. IX. The Synthesis of Some 6-Substituted Purines

22 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

The purine path to chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

6‐Methylmercaptopurine Riboside Is a Potent and Selective Inhibitor of Nerve Growth Factor‐Activated Protein Kinase N

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

Association of a purine-analogue-sensitive protein kinase activity with p75 nerve growth factor receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

Orphan nuclear receptors: from gene to function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

Identification of a potential nurr1 response element that activates the tyrosine hydroxylase gene promoter in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

Dopamine neuron agenesis in Nurr1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

Dopamine biosynthesis is selectively abolished in substantia nigra/ventral tegmental area but not in hypothalamic neurons in mice with targeted disruption of the Nurr1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

Novel dimeric Nur77 signaling mechanism in endocrine and lymphoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

Antagonism between Nur77 and glucocorticoid receptor for control of transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

Involvement of the nuclear orphan receptor NURR1 in the regulation of corticotropin-releasing hormone expression and actions in human inflammatory arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

LXR, a nuclear receptor that defines a distinct retinoid response pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

Identification of a nuclear receptor for bile acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

Identification of the DNA binding site for NGFI-B by genetic selection in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

Akt phosphorylates and regulates the orphan nuclear receptor Nur77

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

Activation and induction of NUR77/NURR1 in corticotrophs by CRH/cAMP: involvement of calcium, protein kinase A, and MAPK pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

Axon Outgrowth Is Regulated by an Intracellular Purine-sensitive Mechanism in Retinal Ganglion Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M302167200

Interaction of deoxyguanosine nucleotide analogs with human telomerase

21 January 2018

5

1 reference

https://api.crossref.org/works/10.1074/JBC.M302167200

A purine-sensitive pathway regulates multiple genes involved in axon regeneration in goldfish retinal ganglion cells

26 December 2023

9

1 reference

https://api.crossref.org/works/10.1074/JBC.M302167200

26 December 2023

Molecular Pharmacology

10

51

414

Hortelano

1997

1 reference

https://api.crossref.org/works/10.1074/JBC.M302167200

26 December 2023

12

20

689

Giguere

1999

1 reference

https://api.crossref.org/works/10.1074/JBC.M302167200

Neuroendocrine regulation of the hypothalamic pituitary adrenal axis by the nurr1/nur77 subfamily of nuclear receptors

26 December 2023

22

1 reference

https://api.crossref.org/works/10.1074/JBC.M302167200

The importance of methylthio-IMP for methylmercaptopurine ribonucleoside (Me-MPR) cytotoxicity in Molt F4 human malignant T-lymphoblasts

26 December 2023

39

1 reference

https://api.crossref.org/works/10.1074/JBC.M302167200

26 December 2023

40

34

738

Tidd

1974

1 reference

https://api.crossref.org/works/10.1074/JBC.M302167200

26 December 2023

41

40

99

Hoki

1990

1 reference

https://api.crossref.org/works/10.1074/JBC.M302167200

Reversal of methylmercaptopurine ribonucleoside cytotoxicity by purine ribonucleosides and adenine

26 December 2023

42

1 reference

https://api.crossref.org/works/10.1074/JBC.M302167200

26 December 2023

43

59

2417

Presta

1999

1 reference

https://api.crossref.org/works/10.1074/JBC.M302167200

26 December 2023

Identifiers

1 reference

22 September 2017

1 reference