(Q40662696)

22 September 2017

title

A novel RGD antagonist that targets both alphavbeta3 and alpha5beta1 induces apoptosis of angiogenic endothelial cells on type I collagen (English)

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22 September 2017

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Karen Meerovitch

1

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22 September 2017

Frédéric Bergeron

2

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22 September 2017

Lorraine Leblond

3

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22 September 2017

Brigitte Grouix

4

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22 September 2017

Cathy Poirier

5

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22 September 2017

Monica Bubenik

6

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22 September 2017

Laval Chan

7

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22 September 2017

Henriette Gourdeau

8

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22 September 2017

Terry Bowlin

9

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22 September 2017

Giorgio Attardo

10

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22 September 2017

language of work or name

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1 February 2003

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22 September 2017

published in

Vascular Pharmacology

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22 September 2017

volume

40

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22 September 2017

issue

2

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22 September 2017

page(s)

77-89

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Glycoprotein IIb/IIIa antagonists induce apoptosis in rat cardiomyocytes by caspase-3 activation

22 September 2017

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Integrin alpha v beta 3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor alpha 5 beta 1.

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Requirement of vascular integrin alpha v beta 3 for angiogenesis

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Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

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Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin

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RGD peptides induce apoptosis by direct caspase-3 activation.

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7 January 2021

Affinity of integrins for damaged extracellular matrix: alpha v beta 3 binds to denatured collagen type I through RGD sites

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7 January 2021

Disruption of epithelial cell-matrix interactions induces apoptosis

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alpha(v)beta(3) Integrin antagonists as inhibitors of bone resorption

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Inhibition of angiogenesis by thrombospondin-1 is mediated by 2 independent regions within the type 1 repeats

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Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alpha v beta 3 integrin to promote epidermal growth factor receptor phosphorylation and growth

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Matrix metalloproteinase and alphavbeta3 integrin-dependent vascular smooth muscle cell invasion through a type I collagen lattice

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7 January 2021

Regulation of angiogenesis in vivo by ligation of integrin alpha5beta1 with the central cell-binding domain of fibronectin

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7 January 2021

A simplified method for growth of human microvascular endothelial cells results in decreased senescence and continued responsiveness to cytokines and growth factors.

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7 January 2021

Induction of apoptotic cell death in vascular endothelial cells cultured in three-dimensional collagen lattice

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Synergy between an antiangiogenic integrin alphav antagonist and an antibody-cytokine fusion protein eradicates spontaneous tumor metastases.

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The extracellular matrix as a cell survival factor

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Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines

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Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen

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Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI

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Ligand binding to integrins

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7 January 2021

Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells

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Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins

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7 January 2021

Growth factor-induced angiogenesis in vivo requires specific cleavage of fibrillar type I collagen.

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7 January 2021

Adhesive properties of osteopontin: regulation by a naturally occurring thrombin-cleavage in close proximity to the GRGDS cell-binding domain

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7 January 2021

Matrix metalloproteinases in angiogenesis: a moving target for therapeutic intervention

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7 January 2021

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7 January 2021

Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins

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7 January 2021

Structural Requirements of Echistatin for the Recognition of αvβ3and α5β1Integrins

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Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo

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7 January 2021

Cell Adhesion Receptors for Native and Denatured Type I Collagens and Fibronectin in Rabbit Arterial Smooth Muscle Cells in Culture

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7 January 2021

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Identifiers

DOI

1 reference

22 September 2017

1 reference