(Q40667913)

22 September 2017

1 reference

title

Mechanisms of action of the p53 tumor suppressor and prospects for cancer gene therapy by reconstitution of p53 function (English)

1 reference

22 September 2017

0 references

1 reference

Roemer K

1

1 reference

PubMed ID

8024199

22 September 2017

Friedmann T

series ordinal

2

1 reference

PubMed ID

8024199

22 September 2017

language of work or name

English

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publication date

1 May 1994

1 reference

Annals of the New York Academy of Sciences

22 September 2017

1 reference

22 September 2017

716

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22 September 2017

265-80; discussion 280-2

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

22 September 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Characterization of the human p53 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Localization of gene for human p53 tumour antigen to band 17p13.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Human p53 oncogene contains one promoter upstream of exon 1 and a second, stronger promoter within intron 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Immunologically distinct p53 molecules generated by alternative splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

p53 is covalently linked to 5.8S rRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Tumor suppressor p53: analysis of wild-type and mutant p53 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Regulation of the specific DNA binding function of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

A mutant p53 protein is required for maintenance of the transformed phenotype in cells transformed with p53 plus ras cDNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Phosphorylation sites in the amino-terminal region of mouse p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

The murine p53 protein blocks replication of SV40 DNA in vitro by inhibiting the initiation functions of SV40 large T antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Definition of a consensus binding site for p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

The MCK enhancer contains a p53 responsive element

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

The tumor suppressor p53 regulates its own transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Wild-type p53 can down-modulate the activity of various promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Wild-type p53 binds to the TATA-binding protein and represses transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

The p53 activation domain binds the TATA box-binding polypeptide in Holo-TFIID, and a neighboring p53 domain inhibits transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Physical and functional interaction between WT1 and p53 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Growth regulation of a cellular tumour antigen, p53, in nontransformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Wild-type p53 is a cell cycle checkpoint determinant following irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Cancer. p53, guardian of the genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Role of the p53 Protein in Cell Proliferation as Studied by Microinjection of Monoclonal Antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

p53 is required for radiation-induced apoptosis in mouse thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Thymocyte apoptosis induced by p53-dependent and independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Involvement of wild-type p53 in pre-B-cell differentiation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

T antigen is bound to a host protein in SY40-transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Rearrangements of the cellular p53 gene in erythroleukaemic cells transformed by Friend virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

The p53 proto-oncogene can act as a suppressor of transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Wild-type p53 can inhibit oncogene-mediated focus formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Rearrangement of the p53 gene in human osteogenic sarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Mutations in the p53 gene occur in diverse human tumour types

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Reconstitution of p53 expression in a nonproducer Ab-MuLV-transformed cell line by transfection of a functional p53 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Gain of function mutations in p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Two Distinct Mechanisms Regulate the Levels of a Cellular Tumor Antigen, p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Mouse p53 inhibits SV40 origin-dependent DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Expression of wild-type p53 is not compatible with continued growth of p53-negative tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Concepts and strategies for human gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Post-Translational Regulation of the 54K Cellular Tumor Antigen in Normal and Transformed Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Amplification of a gene encoding a p53-associated protein in human sarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

p53 functions as a cell cycle control protein in osteosarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Inhibition of DNA replication factor RPA by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Wild-type p53 activates transcription in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

Overproduction of p53 antigen makes established cells highly tumorigenic

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1749-6632.1994.TB21718.X

10.1111/J.1749-6632.1994.TB21718.X

21 January 2018

Identifiers

DOI

1 reference

22 September 2017

1 reference

PubMed ID

8024199