(Q40670213)

22 September 2017

title

Role of the connecting peptide in insulin biosynthesis (English)

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22 September 2017

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Ming Liu

1

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22 September 2017

Jose Ramos-Castañeda

series ordinal

2

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22 September 2017

Peter Arvan

series ordinal

3

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22 September 2017

language of work or name

English

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publication date

14 February 2003

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Journal of Biological Chemistry

22 September 2017

published in

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22 September 2017

volume

278

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22 September 2017

issue

17

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22 September 2017

page(s)

14798-14805

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The insulin A and B chains contain structural information for the formation of the native molecule. Studies with protein disulphide-isomerase

22 September 2017

cites work

1 reference

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21 January 2018

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21 January 2018

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21 January 2018

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Structure of a protein in a kinetic trap

21 January 2018

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21 January 2018

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The different energetic state of the intra A-chain/domain disulfide of insulin and insulin-like growth factor 1 is mainly controlled by their B-chain/domain.

21 January 2018

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The different folding behavior of insulin and insulin-like growth factor 1 is mainly controlled by their B-chain/domain

21 January 2018

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Intracellular transport of proinsulin in pancreatic beta-cells. Structural maturation probed by disulfide accessibility

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi

21 January 2018

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21 January 2018

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21 January 2018

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Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

21 January 2018

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Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response

21 January 2018

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XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

21 January 2018

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IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

21 January 2018

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ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response

21 January 2018

1 reference

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Catalytic activity and chaperone function of human protein-disulfide isomerase are required for the efficient refolding of proinsulin

21 January 2018

1 reference

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Secretory pathway quality control operating in Golgi, plasmalemmal, and endosomal systems

21 January 2018

1 reference

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Effects of cysteine to serine substitutions in the two inter-chain disulfide bonds of insulin

21 January 2018

1 reference

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21 January 2018

1 reference

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A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M212070200

1 reference

22 September 2017

1 reference