(Q40675146)

22 September 2017

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title

MAP kinases ERK1 and ERK2: pleiotropic enzymes in a ubiquitous signaling network (English)

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22 September 2017

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Robbins DJ

1

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22 September 2017

Zhen E

2

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22 September 2017

Cheng M

3

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22 September 2017

Xu S

4

1 reference

22 September 2017

Ebert D

5

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22 September 2017

Cobb MH

6

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22 September 2017

1 January 1994

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Advances in Cancer Research

22 September 2017

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22 September 2017

63

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22 September 2017

93-116

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Identification of an Activator of the Microtubule‐Associated Protein 2 Kinases ERK1 and ERK2 in PC12 Cells Stimulated with Nerve Growth Factor or Bradykinin

22 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Phorbol ester stimulates a protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Raf-1 is a potential substrate for mitogen-activated protein kinase in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Purification and properties of extracellular signal-regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

An osmosensing signal transduction pathway in yeast.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Order of action of components in the yeast pheromone response pathway revealed with a dominant allele of the STE11 kinase and the multiple phosphorylation of the STE7 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Nuclear localization and regulation of erk- and rsk-encoded protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mpk from sea star oocytes and participate in the regulation of pp90rsk activity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Extracellular signal-regulated kinases: ERKs in progress

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Mouse Erk-1 gene product is a serine/threonine protein kinase that has the potential to phosphorylate tyrosine

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

MsERK1: a mitogen-activated protein kinase from a flowering plant.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

FUS3 phosphorylates multiple components of the mating signal transduction cascade: evidence for STE12 and FAR1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Mitogen-activated protein kinase activation resulting from selective oncogene expression in NIH 3T3 and rat 1a cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Signal transduction in Saccharomyces cerevisiae requires tyrosine and threonine phosphorylation of FUS3 and KSS1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Heterogeneous expression of four MAP kinase isoforms in human tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

In vitro effects on microtubule dynamics of purified Xenopus M phase-activated MAP kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Mutants of Saccharomyces cerevisiae unresponsive to cell division control by polypeptide mating hormone

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Ordered phosphorylation of p42mapk by MAP kinase kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Sequence of pp42/MAP kinase, a serine/threonine kinase regulated by tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Activation of the MAP kinase pathway by the protein kinase raf

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

A Xenopus ribosomal protein S6 kinase has two apparent kinase domains that are each similar to distinct protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Pheromone response in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Raf-1 activates MAP kinase-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Growth factor-induced activation of a kinase activity which causes regulatory phosphorylation of p42/microtubule-associated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Cytosolic phospholipase A2 is coupled to hormonally regulated release of arachidonic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

cPLA2 is phosphorylated and activated by MAP kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

NGF and other growth factors induce an association between ERK1 and the NGF receptor, gp140prototrk

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Signal transduction during pheromone response in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Signal transduction by the epidermal growth factor receptor after functional desensitization of the receptor tyrosine protein kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Activation of myelin basic protein kinases during echinoderm oocyte maturation and egg fertilization

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

FAR1 links the signal transduction pathway to the cell cycle machinery in yeast.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Requirements for Phosphorylation of Map Kinase During Meiosis in Xenopus Oocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Tyrosine phosphorylation and activation of homologous protein kinases during oocyte maturation and mitogenic activation of fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Phosphorylation of c-jun mediated by MAP kinases.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

A dominant truncation allele identifies a gene, STE20, that encodes a putative protein kinase necessary for mating in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Extracellular signal-regulated kinases 2 autophosphorylates on a subset of peptides phosphorylated in intact cells in response to insulin and nerve growth factor: analysis by peptide mapping

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Identification of Tyr-185 as the site of tyrosine autophosphorylation of recombinant mitogen-activated protein kinase p42mapk

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Rapid phosphorylation of MAP-2-related cytoplasmic and nuclear Mr 300,000 protein by serine kinases after growth stimulation in quiescent cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Purified maturation promoting factor phosphorylates pp60c-src at the sites phosphorylated during fibroblast mitosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Identification of insulin-stimulated protein kinase-1 as the rabbit equivalent of rskmo-2. Identification of two threonines phosphorylated during activation by mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Epidermal growth factor (EGF) receptor T669 peptide kinase from 3T3-L1 cells is an EGF-stimulated "MAP" kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Complex formation between RAS and RAF and other protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Mammalian Ras interacts directly with the serine/threonine kinase Raf

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Autophosphorylation in vitro of recombinant 42-kilodalton mitogen-activated protein kinase on tyrosine

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Renaturation and partial peptide sequencing of mitogen-activated protein kinase (MAP kinase) activator from rabbit skeletal muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Crystallization and preliminary X-ray studies of extracellular signal-regulated kinase-2/MAP kinase with an incorporated His-tag

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2808%2960399-1

7 January 2021

10.1016/S0065-230X(08)60399-1

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