(Q40677247)

English

Amifostine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential as a radioprotector and cytotoxic chemoprotector

scientific article published on December 1995

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

1 reference

Europe PubMed Central

Amifostine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential as a radioprotector and cytotoxic chemoprotector (English)

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

0 references

1 reference

ChEBI release 2020-05-28

pharmacokinetics

1 reference

based on heuristic

inferred from title

pharmacodynamics

1 reference

based on heuristic

inferred from title

author name string

C M Spencer

1

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

K L Goa

2

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

1 December 1995

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

50

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

1001-1031

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Modification of the oral radiation death syndrome with combined WR-2721 and misonidazole

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioprotection of mouse skin vasculature and the RIF-1 fibrosarcoma by WR-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection by WR-2721 against radiation plus cis-diamminedichloroplatinum II caused injury to colonic epithelium in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modification of WR-2721 radiation protection from gastrointestinal injury and death in mice by 2-mercaptopropionylglycine

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of Ethiofos on cytotoxicity of pharmacological purging protocols used for autologous marrow grafts in acute lymphoblastic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radiosensitisation and radioprotection by BSO and WR-2721: the role of oxygenation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of recombinant human granulocyte-macrophage colony-stimulating factor on myelosuppression induced by multiple cycles of high-dose chemotherapy in patients with advanced breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radiation protection in vivo by prostaglandins and related compounds of the arachidonic acid cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of WR 2721 on radiation response of canine soft tissue sarcomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modification of stromal radiosensitivity by misonidazole and WR-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase I trial of amifostine (WR-2721) and melphalan in children with refractory cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioprotection of mouse jejunum by WR-2721 and WR-1065: effects on DNA strand-break induction and rejoining

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of tumours with the combination of WR-2721 and cis-dichlorodiammineplatinum (II) or cyclophosphamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioprotection of two mouse tumors by WR-2721 in single and fractionated treatments

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection against cis-diamminedichloroplatinum cytotoxicity and mutagenicity in V79 cells by 2-[(aminopropyl)amino]ethanethiol

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraduodenal administration of ethiofos (WR-2721): dose proportionality study in the rhesus monkey

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WR-2721 as cytotoxic and radioprotective agent in treatment of murine lymphoma with total body irradiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative effects of amifostine (Ethyol) on normal hematopoietic stem cells versus human leukemic cells during ex vivo purging in autologous bone marrow transplants

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection and potentiation of nitrogen mustard cytotoxicity by WR-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uptake of WR-2721 derivatives by cells in culture: identification of the transported form of the drug

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypocalcemia and Inhibition of Parathyroid Hormone Secretion after Administration of WR-2721 (a Radioprotective and Chemoprotective Agent)

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human pharmacokinetics of WR-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical trials of WR-2721 and cis-platinum

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modification of tumour and host response to cyclophosphamide by misonidazole and by WR 2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Final report on phase I trial of WR-2721 before protracted fractionated radiation therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection of mouse bone marrow by WR-2721 after fractionated irradiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxicity of WR-2721 administered in single and multiple doses

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of X ray dose levels on normal tissue radioprotection by WR-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adjunctive use of ethiofos (WR-2721) with free radical-generating chemotherapeutic agents in mice: new caveats for therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioprotection of mouse colony forming units-spleen against heavy-charged particle damage by WR 2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the clastogenic effect of cyclophosphamide by WR-2721 in the bone marrow of mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radiation protection of murine intestine by WR-2721, 16,16-dimethyl prostaglandin E2, and the combination of both agents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioprotective effect of combinations of WR-2721 and mercaptopropionylglycine on mouse bone marrow chromosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WR-2,721: Enhanced chemoprotection by increasing cyclophosphamide activation with phenobarbitol

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modification of the radiation response of the mouse kidney by misonidazole and WR-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2-[(Aminopropyl)amino]ethanethiol (WR1065) is anti-neoplastic and anti-mutagenic when given during 60Co gamma-ray irradiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antimutagenic properties of WR 2721 and of a radioprotective mixture, ATP-AET-serotonin, with regard to X ray induced reciprocal translocations in mouse spermatogonia

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential chemoprotection of normal and malignant tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhaled thiol and phosphorothiol radioprotectors fail to protect the mouse lung

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of WR-2721 in normal and malignant tissues of mice and rats bearing solid tumors: dependence on tumor type, drug dose and species.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine improves the antileukemic therapeutic index of mafosfamide: implications for bone marrow purging

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I Controlled trials of WR-2721 and cyclophosphamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purging of small cell lung cancer cells from human bone marrow using ethiofos (WR-2721) and light-activated merocyanine 540 phototreatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of tumor size on S-2-(3-aminopropylamino)ethylphosphorothioic acid and misonidazole alteration of tumor response to cyclophosphamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WR-2721 protection of pneumonitis and fibrosis in mouse lung after single doses of x rays

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WR-2721 and high-dose cisplatin: an active combination in the treatment of metastatic melanoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of synergistic toxicity of the radioprotective agent, WR2721, and 6-hydroxydopamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential protection against cytotoxic chemotherapeutic effects on bone marrow CFUs by Wr-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WR 2721 modification of type II cell and endothelial cell function in mouse lung after single doses of radiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical study of radioprotective effects of amifostine (YM-08310, WR-2721) on long-term outcome for patients with cervical cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of WR2721 on DNA cross-linking by nitrogen mustard in normal mouse bone marrow and leukemia cells in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic pathways of WR-2721 (ethyol, amifostine) in the BALB/c mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical use of radioprotector amifostine (YM-08310)

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytotoxic effects of WR-2721 on mouse testicular cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effect of S-2-(3-aminopropylamino)ethylphosphorothioic acid against induction of altered hepatocyte foci in rats treated once with gamma-radiation within one day after birth

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improvement in radiotherapy for a murine sarcoma by indomethacin plus WR-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparison of radioprotection from three neutron sources and 60Co by WR-2721 and WR-151327

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of Cultured Mammalian Cells with WR-2721 and Its Thiol, WR-1065: Implications for Mechanisms of Radioprotection

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection of spermatogonial survival and testicular function by WR-2721 against high and low doses of radiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transplacental uptake of WR 2721 by the rat embryo

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Phase I study of WR-2721 in combination with total body irradiation (TBI) in patients with refractory lymphoid malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modification of radiation-induced carcinogenesis in mice by misonidazole and WR-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Factors influencing the oxidation of the radioprotector WR-1065

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The radioprotector WR-2721 reduces neutron-induced mutations at the hypoxanthine-guanine phosphoribosyl transferase locus in mouse splenocytes when administered prior to or following irradiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radiobiolgoical and biochemical studies of thiophosphate radioprotective compounds related to cysteamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antimutagenic effects of radioprotector WR-2721 against fission-spectrum neurons and 60Co gamma-rays in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of radiation carcinogenesis in mice by S-2-(3-aminopropylamino)-ethylphosphorothioic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Radioprotective Effects of WR-2721 on Radiation-Induced Goblet Cell Loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Further studies on selective radioprotection by organic zinc salts and synergism of zinc aspartate with WR 2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The time course of radioprotection by WR 2721 in mouse skin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recombinant human granulocyte-macrophage colony-stimulating factor as an adjunct to conventional-dose ifosfamide-based chemotherapy for patients with advanced or relapsed germ cell tumors: a randomized trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the protective effects of three phosphorothioate radioprotectors in the RIF-1 tumor

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined modality radioprotection: the use of glucan and selenium with WR-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time dependence of the selective modulation of cisplatin-induced nephrotoxicity by WR2721 in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of misonidazole combined with WR2721 on tumour response and leucopenia due to cyclophosphamide or melphalan

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraoperative radiotherapy with localized radioprotection: Diminished duodenal toxicity with intraluminal WR2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Postirradiation treatment with granulocyte colony-stimulating factor and preirradiation WR-2721 administration synergize to enhance hemopoietic reconstitution and increase survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pilot trial of cisplatin, radiation, and WR2721 in carcinoma of the uterine cervix: a New York Gynecologic Oncology Group study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[An evaluation of the clinical usefulness of amifostine (YM-08310), radioprotective agent. A double-blind placebo-controlled study. 2. Abdominal and pelvic tumors]

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection of mouse jejunal crypt cells by WR-2721 after small doses of radiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of WR-2721.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical study of the radioprotective effects of Amifostine (YM-08310, WR-2721) on chronic radiation injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical trial of the effect of S-2-(3-aminopropylamino)-ethylphosphorothioic acid (WR-2721) (NSC 296961) on the toxicity of cyclophosphamide

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modification by WR 2721 of the response to chemotherapy of tumours and normal tissues in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection of acute and late radiation damage of the gastrointestinal tract by WR-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of misonidazole and WR-2721—II. Modification of tumour radiosensitization

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo protection by the aminothiol WR-2721 against neutron-induced carcinogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of tumor type, size, and endpoint on tumor radioprotection by WR-2721.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Active versus passive absorption kinetics as the basis for selective protection of normal tissues by S-2-(3-aminopropylamino)-ethylphosphorothioic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the modulating agent WR2721 on myelotoxicity and antitumour activity in carboplatin-treated mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topical or systemic 16, 16 dm prostaglandin E2 or WR-2721 (WR-1065) protects mice from alopecia after fractionated irradiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of radiation with or without WR-2721 in advanced rectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of cis-platinum renal toxicity by the radioprotective agent WR 2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WR-2721 protects against the hematologic toxicity of cyclophosphamide: a controlled phase II trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection by S-2-(3-aminopropylamino)ethylphosphorothioic acid against radiation- and cyclophosphamide-induced attenuation in antitumor resistance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amifostine (WR-2721) shortens the engraftment period of 4-hydroperoxycyclophosphamide-purged bone marrow in breast cancer patients receiving high-dose chemotherapy with autologous bone marrow support

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection against late effects of radiation by S-2-(3-aminopropylamino)-ethylphosphorothioic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioprotection of mouse skin by WR-2721 in single and fractionated treatments

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioprotection by WR-2721 in vitro at low oxygen tensions: Implications for its mechanisms of action

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Postirradiation glucan administration enhances the radioprotective effects of WR-2721.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection by WR-2721 of the toxicity induced by the combination of cisplatin and 5-fluorouracil

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioprotection in rat spinal cord with WR-2721 following cerebral lateral intraventricular injection

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of radiosensitizers and WR-2721. I. Modification of skin radioprotection

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cystine depletion by WR-1065 in cystinotic cells. Mechanism of action

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-acyl dehydroalanines protect from radiation toxicity and inhibit radiation carcinogenesis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of WR-1065 in mouse tissue following treatment with WR-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radiation response of E. coli after combined treatment with misonidazole and WR-2721 at various oxygen concentrations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cisplatin-associated neurotoxicity: can it be prevented?

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I/II trials of WR-2721 and cis-platinum

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioprotective effects of WR-2721, Broncho-Vaxom and their combinations: survival, myelopoietic restoration and induction of colony-stimulating activity in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Post-irradiation modification of O2, N2, and N2O-mediated damage in dry barley seeds by glutathione and cysteine: probable radiation chemical events.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomized clinical trial of mitomycin-C with or without pretreatment with WR-2721 in patients with advanced colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioprotection by WR-2721 of gamma-irradiated rat parotid gland: effect on gland weight and secretion at 8-10 days post irradiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of 35 S-Labeled WR-2721 in Normal and Malignant Tissues of the Mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of the modulating agent WR2721 and its main metabolites on the formation and stability of cisplatin-DNA adducts in vitro in comparison to the effects of thiosulphate and diethyldithiocarbamate

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential protection of normal and malignant tissues against the cytotoxic effects of mechlorethamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carboplatin combined with amifostine, a bone marrow protectant, in the treatment of non-small-cell lung cancer: a randomised phase II study

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cisplatin neuropathy. Risk factors, prognosis, and protection by WR-2721.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Duration and degree of radioprotection of WR-2721 in mice following its intraperitoneal, intramuscular and subcutaneous administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variation in normal tissue responsiveness to WR-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I study of WR-2721 and carboplatin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection by WR-2721 of human bone marrow function following irradiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dose and interval relationship for the interaction of WR-2721 and nitrogen mustard with normal and malignant cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of misonidazole, SR-2508, RSU-1069 and WR-2721 on spontaneous metastases in C57BL mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative biodistribution and radioprotection studies with three radioprotective drugs in mouse tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein binding of N-2-mercaptoethyl-1,3-diaminopropane via mixed disulfide formation after oral administration of WR 2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of WR-2721 in radiotherapy and/or chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in oxygen transport following WR-2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effects of 2-[(aminopropyl)amino] ethanethiol against bleomycin and nitrogen mustard-induced mutagenicity in V79 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioprotection of cells in culture by WR-2721 and derivatives: form of the drug responsible for protection.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective inhibition of the nephrotoxicity of cis-dichlorodiammineplatinum(II) by WR-2721 without altering its antitumor properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection of mice against fission neutron irradiation by WR-2721 or WR-151327

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radiation-induced lymphoid tumors and radiation lethality are inhibited by combined treatment with small doses of zinc aspartate and WR 2721

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracolonic WR 2721 protection of the rat colon from acute radiation injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dose-intensive therapy for breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[An evaluation of the clinical usefulness of amifostine (YM-08310), radioprotective agent. A double-blind placebo-controlled study. 1. Head and neck tumors]

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Management of hypocalcemic effects of WR2721 administered on a daily times five schedule with cisplatin and radiation therapy. The New York Gynecologic Oncology Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The modification of melphalan toxicity in tumor bearing mice by S-2-(3-aminopropylamino)-ethylphosphorothioic acid (WR2721)

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection of mouse lung by WR-2721 after fractionated doses of irradiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preliminary results of a pilot study using WR-2721 before fractionated irradiation of the head and neck to reduce salivary gland dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Final report of the phase I trial of single-dose WR-2721 [S-2-(3-aminopropylamino)ethylphosphorothioic acid]

1 reference

https://pubmed.ncbi.nlm.nih.gov/8612469

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2165/00003495-199550060-00008

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

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