(Q40679508)

English

Constitutive activation of c-kit by the juxtamembrane but not the catalytic domain mutations is inhibited selectively by tyrosine kinase inhibitors STI571 and AG1296.

scientific article published on December 2002

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12512837%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

Constitutive activation of c-kit by the juxtamembrane but not the catalytic domain mutations is inhibited selectively by tyrosine kinase inhibitors STI571 and AG1296 (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12512837%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

1 reference

based on heuristic

inferred from title

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12512837%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

author name string

Shuji Ueda

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12512837%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

Hirokazu Ikeda

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12512837%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

Masao Mizuki

3

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12512837%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

Itaru Matsumura

5

1 reference

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16 December 2019

Hirokazu Tanaka

6

1 reference

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16 December 2019

Hirohiko Shibayama

7

1 reference

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PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12512837%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

Hiroyuki Sugahara

8

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12512837%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

Emi Takai

9

1 reference

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PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12512837%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

Xian Zhang

10

1 reference

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16 December 2019

Takashi Machii

11

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12512837%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

Yuzuru Kanakura

12

1 reference

Europe PubMed Central

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16 December 2019

language of work or name

1 reference

based on heuristic

inferred from title

publication date

1 December 2002

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12512837%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

International Journal of Hematology

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12512837%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

76

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Europe PubMed Central

PubMed publication ID

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16 December 2019

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12512837%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

427-435

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12512837%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation analysis of C-KIT in patients with myelodysplastic syndromes without mastocytosis and cases of systemic mastocytosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hereditary anemias of the mouse: a review for geneticists

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Germline mutation in the juxtamembrane domain of the kit gene in a family with gastrointestinal stromal tumors and urticaria pigmentosa

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetically mast-cell-deficient W/Wv and Sl/Sld mice. Their value for the analysis of the roles of mast cells in biologic responses in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activating mutation in the catalytic domain of c-kit elicits hematopoietic transformation by receptor self-association not at the ligand-induced dimerization site.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-kit mutation and osteopetrosis-like osteopathy in a patient with systemic mast cell disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive activation of c-kit in FMA3 murine mastocytoma cells caused by deletion of seven amino acids at the juxtamembrane domain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial gastrointestinal stromal tumor with hyperpigmentation: association with a germline mutation of the c-kit gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel gain-of-function mutation of c-kit gene in gastrointestinal stromal tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinicopathological features of gastric stromal tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligand-independent activation of c-kit receptor tyrosine kinase in a murine mastocytoma cell line P-815 generated by a point mutation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical correlates of the presence of the Asp816Val c-kit mutation in the peripheral blood mononuclear cells of patients with mastocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical roles of c-Kit tyrosine residues 567 and 719 in stem cell factor-induced chemotaxis: contribution of src family kinase and PI3-kinase on calcium mobilization and cell migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disturbed intestinal movement, bile reflux to the stomach, and deficiency of c-kit-expressing cells in Ws/Ws mutant rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Systemic mastocytosis associated with acute myeloid leukaemia: report of two cases and detection of the c-kit mutation Asp-816 to Val

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

pEF-BOS, a powerful mammalian expression vector

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family--oncogenic activation of v-kit involves deletion of extracellular domain and C terminus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneity of mast cells and phenotypic change between subpopulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neoplastic transformation of normal hematopoietic cells by constitutively activating mutations of c-kit receptor tyrosine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substitution of an aspartic acid results in constitutive activation of c-kit receptor tyrosine kinase in a rat tumor mast cell line RBL-2H3

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: a prospective study

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

KIT activation is a ubiquitous feature of gastrointestinal stromal tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cell lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial gastrointestinal stromal tumours with germline mutation of the KIT gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mastocytosis cells bearing a c-kit activating point mutation are characterized by hypersensitivity to stem cell factor and increased apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12512837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF02982808

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12512837%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12512837%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

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