(Q40683693)

22 September 2017

title

Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic beta-cells (English)

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22 September 2017

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reactive oxygen species

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Koji Sakai

1

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22 September 2017

Kazuya Matsumoto

2

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22 September 2017

Takeshi Nishikawa

3

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22 September 2017

Mihoshi Suefuji

4

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22 September 2017

Kazuhiko Nakamaru

5

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22 September 2017

Yoshiaki Hirashima

6

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22 September 2017

Junji Kawashima

7

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22 September 2017

Tetsuya Shirotani

8

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22 September 2017

Kenshi Ichinose

9

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22 September 2017

Michael Brownlee

10

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22 September 2017

Eiichi Araki

11

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22 September 2017

publication date

1 January 2003

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Biochemical and Biophysical Research Communications

22 September 2017

number of pages

7

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based on heuristic

inferred from page(s)

published in

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22 September 2017

volume

300

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22 September 2017

issue

1

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22 September 2017

page(s)

216-222

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Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion

22 September 2017

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Oxidative stress induces p21 expression in pancreatic islet cells: possible implication in beta-cell dysfunction

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Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes.

7 January 2021

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Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells

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Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation

7 January 2021

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Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress

7 January 2021

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Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations

7 January 2021

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Glucose induces an acute increase of superoxide dismutase activity in incubated rat pancreatic islets

7 January 2021

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Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Activation of stimulus-secretion coupling in pancreatic beta-cells by specific products of glucose metabolism. Evidence for privileged signaling by glycolysis.

7 January 2021

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Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion

7 January 2021

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Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity

7 January 2021

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Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial

7 January 2021

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10.1016/S0006-291X(02)02832-2

7 January 2021

Identifiers

DOI

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22 September 2017

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