(Q40686393)

English

DNA replication arrest in XP variant cells after UV exposure is diverted into an Mre11-dependent recombination pathway by the kinase inhibitor wortmannin

scientific article published on December 2002

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scholarly article

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Europe PubMed Central

22 September 2017

DNA replication arrest in XP variant cells after UV exposure is diverted into an Mre11-dependent recombination pathway by the kinase inhibitor wortmannin (English)

1 reference

Europe PubMed Central

22 September 2017

author name string

Limoli CL

1

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Europe PubMed Central

22 September 2017

Laposa R

2

1 reference

Europe PubMed Central

22 September 2017

Cleaver JE

3

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Europe PubMed Central

22 September 2017

language of work or name

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publication date

1 December 2002

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Europe PubMed Central

22 September 2017

Mutation Research

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Europe PubMed Central

22 September 2017

510

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Europe PubMed Central

22 September 2017

121-129

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Europe PubMed Central

22 September 2017

1-2

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Europe PubMed Central

22 September 2017

UV damage, DNA repair and skin carcinogenesis

1 reference

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Eukaryotic DNA polymerases: proposal for a revised nomenclature.

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Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patients

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hRAD30 mutations in the variant form of xeroderma pigmentosum

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The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta

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A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zeta

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The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light

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Human DINB1-encoded DNA polymerase kappa is a promiscuous extender of mispaired primer termini

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Identification of a protein essential for a major pathway used by human cells to avoid UV- induced DNA damage

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Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions

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Polymerase eta deficiency in the xeroderma pigmentosum variant uncovers an overlap between the S phase checkpoint and double-strand break repair

1 reference

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7 January 2021

UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization

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ATM and ATR: networking cellular responses to DNA damage

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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

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Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

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Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

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The Y-family of DNA polymerases

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Structure of the catalytic core of S. cerevisiae DNA polymerase eta: implications for translesion DNA synthesis

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DNA polymerase eta undergoes alternative splicing, protects against UV sensitivity and apoptosis, and suppresses Mre11-dependent recombination

1 reference

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7 January 2021

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

1 reference

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7 January 2021

Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

1 reference

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7 January 2021

Isolation and characterization of the human MRE11 homologue

1 reference

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7 January 2021

The mammalian Mre11-Rad50-nbs1 protein complex: integration of functions in the cellular DNA-damage response

1 reference

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7 January 2021

Caffeine toxicity is inversely related to DNA repair in simian virus 40-transformed xeroderma pigmentosum cells irradiated with ultraviolet light

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7 January 2021

A phosphatidylinositol 3-kinase inhibitor wortmannin induces radioresistant DNA synthesis and sensitizes cells to bleomycin and ionizing radiation

1 reference

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7 January 2021

Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

1 reference

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7 January 2021

Xeroderma pigmentosum variant cells are resistant to immortalization

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7 January 2021

Effects of caffeine on ultraviolet-irradiated mouse L cells

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Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

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A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

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7 January 2021

Physical and functional interactions of human DNA polymerase eta with PCNA

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Analysis of DNA replication forks encountering a pyrimidine dimer in the template to the leading strand

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Checking That Replication Breakdown Is Not Terminal

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Maintenance of genome stability in Saccharomyces cerevisiae

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Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects

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Production of DNA bifilarly substituted with bromodeoxyuridine in the first round of synthesis: branch migration during isolation of cellular DNA

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Accumulation of DNA growing points in caffeine-treated human lymphoblastoid cells

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Characterization of homologous recombination induced by replication inhibition in mammalian cells

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An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells.

1 reference

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Stopping DNA replication in its tracks

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Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint

1 reference

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The DNA replication checkpoint response stabilizes stalled replication forks

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ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones.

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7 January 2021

Identifiers

10.1016/S0027-5107(02)00257-9

1 reference

Europe PubMed Central

22 September 2017

1 reference

Europe PubMed Central

22 September 2017

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