(Q40691164)

English

Cytosine deaminase and thymidine kinase gene therapy in a Dunning rat prostate tumour model: absence of bystander effects and characterisation of 5-fluorocytosine metabolism with 19F-NMR spectroscopy

scientific article published on December 2002

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Cytosine deaminase and thymidine kinase gene therapy in a Dunning rat prostate tumour model: absence of bystander effects and characterisation of 5-fluorocytosine metabolism with 19F-NMR spectroscopy (English)

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

0 references

5-fluorocytosine

1 reference

based on heuristic

inferred from title

author name string

Corban-Wilhelm H

1

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Hull WE

2

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Becker G

3

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Bauder-Wüst U

4

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Greulich D

5

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Debus J

6

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

publication date

1 December 2002

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

9

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Europe PubMed Central

PubMed publication ID

22 September 2017

23

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Europe PubMed Central

PubMed publication ID

22 September 2017

1564-1575

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Biochemical pharmacology and analysis of fluoropyrimidines alone and in combination with modulators

1 reference

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In VivoAdenovirus-Mediated Gene Transfer of theEscherichia coliCytosine Deaminase Gene to Human Colon Carcinoma-Derived Tumors Induces Chemosensitivity to 5-Fluorocytosine

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In vivo replication-deficient adenovirus vector-mediated transduction of the cytosine deaminase gene sensitizes glioma cells to 5-fluorocytosine

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Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with in vivo magnetic resonance spectroscopy

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Enzyme/prodrug therapy for head and neck cancer using a catalytically superior cytosine deaminase

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Metabolism of pyrimidine analogues and their nucleosides

1 reference

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Experimental gene therapy for brain tumors using adenovirus-mediated transfer of cytosine deaminase gene and uracil phosphoribosyltransferase gene with 5-fluorocytosine

1 reference

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Killing Epstein-Barr virus-positive B lymphocytes by gene therapy: comparing the efficacy of cytosine deaminase and herpes simplex virus thymidine kinase

1 reference

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The bystander effect exerted by tumor cells expressing the herpes simplex virus thymidine kinase (HSVtk) gene is dependent on connexin expression and cell communication via gap junctions

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In vitro and in vivo antitumor effects of retrovirus-mediated herpes simplex thymidine kinase gene-transfer in human medulloblastoma

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The bystander effect in the HSVtk/ganciclovir system and its relationship to gap junctional communication

1 reference

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Cytotoxicity of adenoviral-mediated cytosine deaminase plus 5-fluorocytosine gene therapy is superior to thymidine kinase plus acyclovir in a human renal cell carcinoma model

1 reference

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Glioma cells transduced with an Escherichia coli CD/HSV-1 TK fusion gene exhibit enhanced metabolic suicide and radiosensitivity

1 reference

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Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins

1 reference

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Mechanism of 'bystander effect' killing in the herpes simplex thymidine kinase gene therapy model of cancer treatment

1 reference

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Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase

1 reference

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Locoregional administration of 5-fluoro-2'-deoxyuridine (FdUrd) in Novikoff hepatoma in the rat: effects of dose and infusion time on tumor growth and on FdUrd metabolite levels in tumor tissue as determined by 19F-NMR spectroscopy

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Fluorine nuclear magnetic resonance, a privileged tool for metabolic studies of fluoropyrimidine drugs

1 reference

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19F nuclear magnetic resonance study of fluoropyrimidine metabolism in strains of Candida glabrata with specific defects in pyrimidine metabolism

1 reference

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A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumour sensitivity to fluorouracil

1 reference

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Tumor trapping of 5-fluorouracil: in vivo 19F NMR spectroscopic pharmacokinetics in tumor-bearing humans and rabbits

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A pharmacokinetic and pharmacodynamic study in vivo of human HT29 tumours using 19F and 31P magnetic resonance spectroscopy

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Influence of pH on the uptake of 5-fluorouracil into isolated tumour cells

1 reference

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Characterization of the Escherichia coli codBA operon encoding cytosine permease and cytosine deaminase

1 reference

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Detection of cytosine deaminase in genetically modified tumor cells by specific antibodies

1 reference

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

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Assignment and pH dependence of the 19F-NMR resonances from the fluorouracil anabolites involved in fluoropyrimidine chemotherapy

1 reference

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inferred from DOI database lookup

Association of intratumoral pharmacokinetics of fluorouracil with clinical response

1 reference

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inferred from DOI database lookup

Tumor pH: implications for treatment and novel drug design

1 reference

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inferred from DOI database lookup

Identifiers

10.1038/SJ.GT.3301834

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 September 2017

ResearchGate publication ID

0 references

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