(Q40694313)

22 September 2017

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title

Yeast Saccharomyces cerevisiae as a model system to study the cytotoxic activity of the antitumor drug camptothecin (English)

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22 September 2017

main subject

Saccharomyces cerevisiae

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Bjornsti MA

1

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22 September 2017

Knab AM

series ordinal

2

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22 September 2017

Benedetti P

series ordinal

3

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22 September 2017

publication date

1 January 1994

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Cancer Chemotherapy and Pharmacology

22 September 2017

published in

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22 September 2017

volume

34 Suppl

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22 September 2017

page(s)

S1-5

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A novel mutation in DNA topoisomerase I of yeast causes DNA damage and RAD9-dependent cell cycle arrest.

22 September 2017

cites work

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12 December 2020

Getting started with yeast

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12 December 2020

Supercoiling of intracellular DNA can occur in eukaryotic cells.

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12 December 2020

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

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12 December 2020

Cloning of yeast TOP1, the gene encoding DNA topoisomerase I, and construction of mutants defective in both DNA topoisomerase I and DNA topoisomerase II.

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12 December 2020

DNA topoisomerase I is essential in Drosophila melanogaster

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12 December 2020

Mitotic recombination in the rDNA of S. cerevisiae is suppressed by the combined action of DNA topoisomerases I and II.

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12 December 2020

DNA topoisomerase poisons as antitumor drugs

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12 December 2020

cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment

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12 December 2020

Structural modifications of camptothecin and effects on topoisomerase I inhibition

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12 December 2020

Isolation and characterization of a gene encoding DNA topoisomerase I in Drosophila melanogaster

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12 December 2020

Cloning, characterization, and sequence of the yeast DNA topoisomerase I gene

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12 December 2020

Protein-linked DNA strand breaks induced in mammalian cells by camptothecin, an inhibitor of topoisomerase I.

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12 December 2020

Covalent bonds between protein and DNA. Formation of phosphotyrosine linkage between certain DNA topoisomerases and DNA

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12 December 2020

Peptide sequencing and site-directed mutagenesis identify tyrosine-727 as the active site tyrosine of Saccharomyces cerevisiae DNA topoisomerase I.

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12 December 2020

Cellular and SV40 Chromatin: Replication, Segregation, Ubiqiritination, Nuclease-hypersensitive Sites, HMG-containing Nueleosomes, and Heterochromatin-specific Protein

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12 December 2020

On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex

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12 December 2020

DNA topoisomerases: from a laboratory curiosity to a subject in cancer chemotherapy

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12 December 2020

Cloning and sequencing of Schizosaccharomyces pombe DNA topoisomerase I gene, and effect of gene disruption.

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12 December 2020

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin

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12 December 2020

Cloning of Chinese hamster DNA topoisomerase I cDNA and identification of a single point mutation responsible for camptothecin resistance

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12 December 2020

Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells

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12 December 2020

Characterization of vaccinia virus DNA topoisomerase I expressed in Escherichia coli

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12 December 2020

Supercoiling of the DNA template during transcription

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12 December 2020

Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin.

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12 December 2020

Transcription-dependent DNA supercoiling in yeast DNA topoisomerase mutants

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12 December 2020

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12 December 2020

Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin

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12 December 2020

Mapping of the active site tyrosine of eukaryotic DNA topoisomerase I

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12 December 2020

Mapping the active-site tyrosine of vaccinia virus DNA topoisomerase I.

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12 December 2020

Molecular cloning of a cDNA of a camptothecin-resistant human DNA topoisomerase I and identification of mutation sites

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12 December 2020

DNA topoisomerases as targets for cancer therapy

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12 December 2020

Mechanisms of camptothecin resistance in yeast DNA topoisomerase I mutants.

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12 December 2020

A general topoisomerase I-dependent transcriptional repression in the stationary phase in yeast

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12 December 2020

Studies on the antitumor activity, mechanism of action, and cell cycle effects of camptothecin

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12 December 2020

The basis for camptothecin enhancement of DNA breakage by eukaryotic topoisomerase I.

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12 December 2020

DNA topoisomerase-targeting antitumor drugs can be studied in yeast

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12 December 2020

Detection of topoisomerase I gene point mutation in CPT-11 resistant lung cancer cell line

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12 December 2020

Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons

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12 December 2020

DNA topoisomerases: enzymes that control DNA conformation

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12 December 2020

A subthreshold level of DNA topoisomerases leads to the excision of yeast rDNA as extrachromosomal rings

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12 December 2020

DNA topoisomerase I is involved in both repression and activation of transcription

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12 December 2020

DNA is linked to the rat liver DNA nicking-closing enzyme by a phosphodiester bond to tyrosine

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12 December 2020

Camptothecin resistance from a single mutation changing glycine 363 of human DNA topoisomerase I to cysteine

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12 December 2020

Identifiers

DOI

10.1007/BF00684856

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Dimensions Publication ID

22 September 2017

1049851437

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