(Q40694343)

22 September 2017

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title

Novel actions of inhibitors of DNA topoisomerase II in drug-resistant tumor cells (English)

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22 September 2017

Beck WT

1

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22 September 2017

Kim R

series ordinal

2

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22 September 2017

Chen M

series ordinal

3

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22 September 2017

publication date

1 January 1994

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Cancer Chemotherapy and Pharmacology

22 September 2017

published in

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22 September 2017

volume

34 Suppl

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22 September 2017

page(s)

S14-8

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Expression of a mutant DNA topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide

22 September 2017

cites work

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12 December 2020

Topoisomerase-targeting antitumor drugs

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12 December 2020

Isolation of cDNA clones encoding the beta isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24

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12 December 2020

Stabilization of the topoisomerase II-DNA cleavage complex by antineoplastic drugs: inhibition of enzyme-mediated DNA religation by 4'-(9-acridinylamino)methanesulfon-m-anisidide.

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12 December 2020

Altered catalytic activity of and DNA cleavage by DNA topoisomerase II from human leukemic cells selected for resistance to VM-26.

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12 December 2020

In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone

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12 December 2020

Inhibition of type II topoisomerase by fostriecin

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12 December 2020

DNA topoisomerase poisons as antitumor drugs

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12 December 2020

Differential induction of apoptosis in undifferentiated and differentiated HL-60 cells by DNA topoisomerase I and II inhibitors

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12 December 2020

A model for tumor cell killing by topoisomerase poisons.

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12 December 2020

Cell death induced by topoisomerase inhibitors. Role of calcium in mammalian cells

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12 December 2020

Resistance of mammalian tumor cells to inhibitors of DNA topoisomerase II.

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12 December 2020

Teniposide-resistant CEM cells, which express mutant DNA topoisomerase II alpha, when treated with non-complex-stabilizing inhibitors of the enzyme, display no cross-resistance and reveal aberrant functions of the mutant enzyme

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12 December 2020

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

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12 December 2020

Activation of the c-jun protooncogene in human myeloid leukemia cells treated with etoposide

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12 December 2020

Differences in the regulation of protein synthesis, cyclin B accumulation, and cellular growth in response to the inhibition of DNA synthesis in Chinese hamster ovary and HeLa S3 cells

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12 December 2020

Topoisomerase II alpha and topoisomerase II beta genes: characterization and mapping to human chromosomes 17 and 3, respectively

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12 December 2020

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin

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12 December 2020

HT1080/DR4: a P-glycoprotein-negative human fibrosarcoma cell line exhibiting resistance to topoisomerase II-reactive drugs despite the presence of a drug-sensitive topoisomerase II.

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12 December 2020

Drug resistance associated with altered DNA topoisomerase II.

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12 December 2020

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12 December 2020

Identification of a point mutation in the topoisomerase II gene from a human leukemia cell line containing an amsacrine-resistant form of topoisomerase II

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12 December 2020

Camptothecin and its derivatives induce expression of the c-jun protooncogene in human myeloid leukemia cells

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12 December 2020

Participation of p53 protein in the cellular response to DNA damage

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12 December 2020

Etoposide-induced apoptosis in human HL-60 cells is associated with intracellular acidification

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12 December 2020

Mode of action of topoisomerase II-targeting agents at a specific DNA sequence. Uncoupling the DNA binding, cleavage and religation events

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12 December 2020

Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22

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12 December 2020

The role of topoisomerase II alpha and beta in drug resistance

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12 December 2020

Mechanisms of resistance to drugs that inhibit DNA topoisomerases

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12 December 2020

Localization of the active type I DNA topoisomerase gene on human chromosome 20q11.2-13.1, and two pseudogenes on chromosomes 1q23-24 and 22q11.2-13.1.

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12 December 2020

Mechanistic aspects of DNA topoisomerases.

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12 December 2020

The tumor suppressor p53.

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12 December 2020

Mitoxantrone resistance in HL-60 leukemia cells: reduced nuclear topoisomerase II catalytic activity and drug-induced DNA cleavage in association with reduced expression of the topoisomerase II beta isoform

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12 December 2020

Coinduction of c-jun gene expression and internucleosomal DNA fragmentation by ionizing radiation

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12 December 2020

DNA topoisomerases: enzymes that control DNA conformation

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12 December 2020

Biochemical basis for the interactions of type I and type II topoisomerases with DNA.

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12 December 2020

Single-strand conformational polymorphism analysis of the M(r) 170,000 isozyme of DNA topoisomerase II in human tumor cells

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12 December 2020

Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20q12-13.2.

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12 December 2020

Identifiers

DOI

10.1007/BF00684858

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Dimensions Publication ID

22 September 2017

1051275677

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