(Q40697333)

English

Mycophenolic acid inhibits inosine 5'-monophosphate dehydrogenase and suppresses production of pro-inflammatory cytokines, nitric oxide, and LDH in macrophages

scientific article published on March 2002

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scholarly article

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Europe PubMed Central

22 September 2017

Mycophenolic acid inhibits inosine 5'-monophosphate dehydrogenase and suppresses production of pro-inflammatory cytokines, nitric oxide, and LDH in macrophages (English)

1 reference

Europe PubMed Central

22 September 2017

author name string

Charlotte A Jonsson

1

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Europe PubMed Central

22 September 2017

Hans Carlsten

2

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Europe PubMed Central

22 September 2017

language of work or name

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publication date

1 March 2002

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Europe PubMed Central

22 September 2017

Cellular Immunology

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Europe PubMed Central

22 September 2017

216

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Europe PubMed Central

22 September 2017

1-2

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Europe PubMed Central

22 September 2017

93-101

1 reference

Europe PubMed Central

22 September 2017

Mycophenolate mofetil: selective T cell inhibition

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Mycophenolate mofetil: suggested guidelines for use in kidney transplantation

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Efficacy of mycophenolate mofetil in patients with diffuse proliferative lupus nephritis. Hong Kong-Guangzhou Nephrology Study Group

1 reference

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Beneficial effect of the inosine monophosphate dehydrogenase inhibitor mycophenolate mofetil on survival and severity of glomerulonephritis in systemic lupus erythematosus (SLE)-prone MRLlpr/lpr mice

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Mycophenolate Mofetil Ameliorates Perivascular T Lymphocyte Inflammation and Reduces the Double-Negative T Cell Population in SLE-Prone MRLlpr/lpr Mice

1 reference

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Mycophenolate mofetil limits renal damage and prolongs life in murine lupus autoimmune disease

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Inosine monophosphate dehydrogenase (IMPDH) inhibition in vitro suppresses lymphocyte proliferation and the production of immunoglobulins, autoantibodies and cytokines in splenocytes from MRLlpr/lpr mice

1 reference

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The structure of inosine 5'-monophosphate dehydrogenase and the design of novel inhibitors

1 reference

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Mycophenolate mofetil and its mechanisms of action

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Immunological observations on patients with Lesch-Nyhan syndrome, and on the role of de-novo purine synthesis in lymphocyte transformation

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The design and development of an immunosuppressive drug, mycophenolate mofetil

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Mycophenolic acid and some antioxidants induce differentiation of monocytic lineage cells and augment production of the IL-1 receptor antagonist.

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Mycophenolic acid increases apoptosis, lysosomes and lipid droplets in human lymphoid and monocytic cell lines

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Infection and transformation of mouse peritoneal macrophages by simian virus 40.

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Uncoupling of apoptosis and Jun/AP-1 activity in human promonocytic cells treated with DNA-damaging and stress-inducing agents

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Etoposide and cisplatin induced apoptosis in activated RAW 264.7 macrophages is attenuated by cAMP-induced gene expression

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Effect of irradiation, cyclophosphamide, and etoposide (VP-16) on number of peripheral blood and peritoneal leukocytes in mice under normal conditions and during acute inflammatory reaction

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Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

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Cellular interactions in the pathogenesis of lupus nephritis: the role of T cells and macrophages in the amplification of the inflammatory process in the kidney

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Predictive power of the second renal biopsy in lupus nephritis: significance of macrophages

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Nitric oxide: biosynthesis and biological significance

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Nitric oxide synthesis is increased in patients with systemic lupus erythematosus

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Expression of inducible nitric oxide synthase and apoptosis in human lupus nephritis

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The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orall

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Clinical and serologic manifestations of autoimmune disease in MRL-lpr/lpr mice lacking nitric oxide synthase type 2.

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Mycophenolic acid, an inhibitor of IMP dehydrogenase that is also an immunosuppressive agent, suppresses the cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells.

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The nitric oxide and cGMP signal transduction system: regulation and mechanism of action

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Protein translocation at the membrane of the endoplasmic reticulum.

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Intracellular Aspects of the Process of Protein Synthesis

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A part of the transmembrane domain of pro-TNF can function as a cleavable signal sequence that generates a biologically active secretory form of TNF

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The secretory route of the leaderless protein interleukin 1beta involves exocytosis of endolysosome-related vesicles

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Interleukin 1 is processed and released during apoptosis

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Fusion of a signal sequence to the interleukin-1 beta gene directs the protein from cytoplasmic accumulation to extracellular release

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Extracellular ATP activates transcription factor NF-kappaB through the P2Z purinoreceptor by selectively targeting NF-kappaB p65

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Identifiers

10.1016/S0008-8749(02)00502-6

1 reference

Europe PubMed Central

22 September 2017

1 reference

Europe PubMed Central

22 September 2017

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