(Q40700889)

22 September 2017

1 reference

title

Metabolic activation and detoxification of tobacco-specific nitrosamines--a model for cancer prevention strategies (English)

1 reference

22 September 2017

S S Hecht

1

1 reference

PubMed ID

8082576

22 September 2017

language of work or name

English

0 references

publication date

1 January 1994

1 reference

22 September 2017

Drug Metabolism Reviews

1 reference

22 September 2017

26

1 reference

22 September 2017

1-2

1 reference

22 September 2017

373-390

1 reference

Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke.

22 September 2017

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

A study of betel quid carcinogenesis. IX. Comparative carcinogenicity of 3-(methylnitrosamino)propionitrile and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone upon local application to mouse skin and rat oral mucosa.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

Induction of respiratory tract tumors in Syrian golden hamsters by a single dose of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and the effect of smoke inhalation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

Tumorigenic activity of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanol (iso-NNAL) and N'-nitrosonornicotine (NNN) on topical application to Sencar mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

Metabolism of tobacco-specific N-nitrosamines by cultured human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

Metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the patas monkey: pharmacokinetics and characterization of glucuronide metabolites.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

Characterization of a glucuronide metabolite of 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its dose-dependent excretion in the urine of mice and rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

Matabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by cytochrome P450IIB1 in a reconstituted system

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

Evidence for 4-(3-pyridyl)-4-oxobutylation of DNA in F344 rats treated with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

Effects of deuterium substitution on the tumorigenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in A/J mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

Effects of alpha-deuterium substitution on the tumorigenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

Role of DNA methylation in the activation of proto-oncogenes and the induction of pulmonary neoplasia by nitrosamines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

Effects of alpha-deuterium substitution on the mutagenicity of 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

Analysis of mutagenic activity and ability to induce replication of polyoma DNA sequences by different model metabolites of the carcinogenic tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

Lack of correlation between DNA methylation and hepatocarcinogenesis in rats and hamsters treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

Metabolic beta-hydroxylation and N-oxidation of N'-nitrosonornicotine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

Comprehensive analysis of urinary metabolites of N'-nitrosonornicotine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

Investigations of metabolic precursors to hemoglobin and DNA adducts of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

In vivo and in vitro persistence of pyridyloxobutyl DNA adducts from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

Comparative mutagenicity of 4-(carbethoxynitrosamino)-4-(3-pyridyl)butanal and 4-(carbethoxynitrosamino)-1-(3-pyridyl)-1-butanone, model compounds for alpha-hydroxylation of N'-nitrosonornicotine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

Alkylation of macromolecules for detecting mutagenic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

Protein adducts in the molecular dosimetry of chemical carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

DNA adducts in humans as biomarkers of exposure to environmental and occupational carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

Tobacco-specific nitrosamine adducts: studies in laboratory animals and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

Mass spectrometric analysis of tobacco-specific nitrosamine-DNA adducts in smokers and nonsmokers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

Effects of dietary indoles and isothiocyanates on N-nitrosodimethylamine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone alpha-hydroxylation and DNA methylation in rat liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

Effects of alkyl chain length on the inhibition of NNK-induced lung neoplasia in A/J mice by arylalkyl isothiocyanates.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602539409029803

10.3109/03602539409029803

21 January 2018

Identifiers

DOI

1 reference

22 September 2017

1 reference

PubMed ID

8082576