(Q40705435)

22 September 2017

Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice (English)

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22 September 2017

11

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22 September 2017

Niall C Tebbutt

1

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22 September 2017

Andrew S Giraud

2

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22 September 2017

Melissa Inglese

3

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22 September 2017

Brendan Jenkins

4

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22 September 2017

Paul Waring

5

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22 September 2017

Fiona J Clay

6

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22 September 2017

Sina Malki

7

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22 September 2017

Barbara M Alderman

8

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22 September 2017

Dianne Grail

9

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22 September 2017

Frédéric Hollande

10

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22 September 2017

Matthias Ernst

12

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22 September 2017

language of work or name

English

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publication date

9 September 2002

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22 September 2017

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22 September 2017

8

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22 September 2017

1089-1097

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22 September 2017

10

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https://scigraph.springernature.com/pub.10.1038/nm763

22 September 2017

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cites work

Protein modules and signalling networks

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Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

21 January 2018

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Gp130 and the interleukin-6 family of cytokines

21 January 2018

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Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors

21 January 2018

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Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses.

21 January 2018

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X. Trefoil peptide and EGF receptor/ligand transgenic mice

21 January 2018

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Intestinal trefoil factor confers colonic epithelial resistance to apoptosis

21 January 2018

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The role of interleukin-6 in mucosal IgA antibody responses in vivo

21 January 2018

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Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation

21 January 2018

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Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein

21 January 2018

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Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor.

21 January 2018

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Impaired immune and acute-phase responses in interleukin-6-deficient mice.

21 January 2018

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Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation

21 January 2018

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Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders

21 January 2018

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Keratinocyte growth factor ameliorates dextran sodium sulfate colitis in mice

21 January 2018

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Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis

21 January 2018

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HGF regulates tight junctions in new nontumorigenic gastric epithelial cell line

21 January 2018

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Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

21 January 2018

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The trefoil gene family are coordinately expressed immediate-early genes: EGF receptor- and MAP kinase-dependent interregulation

21 January 2018

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DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites

21 January 2018

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Molecular cloning of the rat intestinal trefoil factor gene. Characterization of an intestinal goblet cell-associated promoter

21 January 2018

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Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects

21 January 2018

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Extramedullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R double transgenic mice

21 January 2018

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Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice

21 January 2018

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CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation

21 January 2018

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The trefoil factor 1 participates in gastrointestinal cell differentiation by delaying G1-S phase transition and reducing apoptosis

21 January 2018

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Hypertrophic gastropathy resembling Ménétrier's disease in transgenic mice overexpressing transforming growth factor alpha in the stomach

21 January 2018

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The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.

21 January 2018

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SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130

21 January 2018

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Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

21 January 2018

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Dual signaling role of the protein tyrosine phosphatase SHP-2 in regulating expression of acute-phase plasma proteins by interleukin-6 cytokine receptors in hepatic cells.

21 January 2018

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Spatio-temporal expression of trefoil peptide following severe gastric ulceration in the rat implicates it in late-stage repair processes

21 January 2018

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The carboxyl-terminal domains of gp130-related cytokine receptors are necessary for suppressing embryonic stem cell differentiation. Involvement of STAT3

21 January 2018

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Characterization of the mouse TFF1 (pS2) gene promoter region

21 January 2018

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7 January 2021

Somatic mutations of the trefoil factor family 1 gene in gastric cancer

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7 January 2021

Biliary epithelial trefoil peptide expression is increased in biliary diseases

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7 January 2021

The trefoil peptides spasmolytic polypeptide and intestinal trefoil factor are major secretory products of the rat gut

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7 January 2021

Identifiers

DOI

10.1038/NM763

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Dimensions Publication ID

22 September 2017

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