(Q40708934)

23 September 2017

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title

Cellular models for multiple drug resistance in cancer (English)

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23 September 2017

multiple drug resistance

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Clynes M

1

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23 September 2017

1 March 1993

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In Vitro Cellular & Developmental Biology

23 September 2017

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23 September 2017

29A

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23 September 2017

3 Pt 1

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23 September 2017

171-179

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Mouse-human chimeric antibody MH171 against the multidrug transporter P-glycoprotein.

23 September 2017

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https://api.crossref.org/works/10.1007%2FBF02634176

Differential recognition of mdr1a and mdr1b gene products in multidrug resistant mouse tumour cell lines by different monoclonal antibodies

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02634176

Investigation of the relationship between altered intracellular pH and multidrug resistance in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02634176

Structure and expression of the human MDR (P-glycoprotein) gene family

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02634176

Elevated expression of annexin II (lipocortin II, p36) in a multidrug resistant small cell lung cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02634176

Retention of activity by selected anthracyclines in a multidrug resistant human large cell lung carcinoma line without P-glycoprotein hyperexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02634176

The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02634176

DNA-mediated transfer of multiple drug resistance and plasma membrane glycoprotein expression

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02634176

Expression of a human multidrug resistance cDNA (MDR1) in the bone marrow of transgenic mice: resistance to daunomycin-induced leukopenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02634176

Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02634176

P-glycoprotein overexpression cannot explain the complete doxorubicin-resistance phenotype in rat glioblastoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02634176

Glycosylation of P-glycoprotein in a multidrug-resistant KB cell line, and in the human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02634176

The enzymes of glutathione metabolism: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02634176

Identification of members of the P-glycoprotein multigene family

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02634176

Multidrug resistance (mdr) genes in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02634176

Doxorubicin selected multidrug-resistant small cell lung cancer cell lines characterised by elevated cytoplasmic Ca2+ and resistance modulation by verapamil in absence of P-glycoprotein overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02634176

Identification and Characterization of Three DNA-binding Proteins on the Promoter of the Human MDRl Gene in Drug-sensitive and -resistant Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02634176

A novel multidrug resistance in cultured leukemia and lymphoma cells detected by a monoclonal antibody to 85-kDa protein, MRK20.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02634176

A phase I study on the reversal of multidrug resistance (MDR) in vivo: nifedipine plus etoposide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02634176

Different types of non-P-glycoprotein mediated multiple drug resistance in children with relapsed acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02634176

Cell-specific activity of cis-acting regulatory elements in the promoter of the mouse multidrug resistance gene mdr1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02634176

Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02634176

Non-P-glycoprotein-mediated multidrug resistance with reduced EGF receptor expression in a human large cell lung cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02634176

From amplification to function: the case of the MDR1 gene

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02634176

Hypoxia-induced drug resistance: comparison to P-glycoprotein-associated drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02634176

Immunohistochemical detection of the multi-drug-resistance marker P-glycoprotein in uterine cervical carcinomas and normal cervical tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02634176

Double minute chromosomes carrying the human multidrug resistance 1 and 2 genes are generated from the dimerization of submicroscopic circular DNAs in colchicine-selected KB carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02634176

Amplicon structure in multidrug-resistant murine cells: a nonrearranged region of genomic DNA corresponding to large circular DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02634176

Different mechanisms of decreased drug accumulation in doxorubicin and mitoxantrone resistant variants of the MCF7 human breast cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02634176

Overexpression of P-glycoprotein and glutathione S-transferase-π in resistant non-small cell lung carcinomas of smokers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02634176

The role of glutathione in determining the response of normal and tumor cells to anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02634176

Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies

21 January 2018

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12 December 2020

Analysis of the mechanism of resistance of 7 novel MDR variants

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12 December 2020

Role of cytochrome P-450 from the human CYP3A gene family in the potentiation of morpholino doxorubicin by human liver microsomes

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12 December 2020

Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody

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12 December 2020

Reduced DNA topoisomerase II activity and drug-induced DNA cleavage activity in an adriamycin-resistant human small cell lung carcinoma cell line

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12 December 2020

Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins

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12 December 2020

Altered catalytic activity of and DNA cleavage by DNA topoisomerase II from human leukemic cells selected for resistance to VM-26.

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12 December 2020

The clinical relevance of multidrug resistance

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12 December 2020

Drug transport mechanisms in HL60 cells isolated for resistance to adriamycin: evidence for nuclear drug accumulation and redistribution in resistant cells

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12 December 2020

Expression of the mdr1 gene in human colorectal carcinomas: relationship with multidrug resistance inferred from analysis of human colorectal carcinoma cell lines

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12 December 2020

Biochemical characterization of resistance to mitoxantrone and adriamycin in Caco-2 human colon adenocarcinoma cells: a possible role for glutathione S-transferases

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12 December 2020

Expression of glutathione transferase pi as a predictor for treatment results at different stages of acute nonlymphoblastic leukemia

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12 December 2020

Magnetic-Affinity Cell Sorting of Human Multidrug-Resistant Cells

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12 December 2020

12 V79 Chinese hamster cells genetically engineered for stable expression of cytochromes P450

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12 December 2020

Mechanism of multidrug resistance

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12 December 2020

Multidrug sensitivity phenotype of human lung cancer cells associated with topoisomerase II expression

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12 December 2020

Clinical Relevance of Immunohistochemical Detection of Multidrug Resistance P-Glycoprotein in Breast Carcinoma

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12 December 2020

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

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12 December 2020

Pharmacology of drugs that alter multidrug resistance in cancer

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12 December 2020

Glutathione content and glutathione-S-transferase expression in 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human malignant astrocytoma cell lines

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12 December 2020

Overexpression of multidrug resistance-associated p170-glycoprotein in acute non-lymphocytic leukemia

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12 December 2020

Multidrug resistance phenotype of human BRO melanoma cells transfected with a wild-type human mdr1 complementary DNA.

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12 December 2020

Multidrug resistance in cells transfected with human genes encoding a variant P-glycoprotein and glutathione S-transferase-pi

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12 December 2020

The over-expression of P-glycoprotein in K-562 and DAUDI cells, is associated with a high susceptibility to NK and LAK cells

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12 December 2020

Establishment of two new multi-drug resistant variants of the human tumor line Hep-2.

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12 December 2020

An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

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12 December 2020

Expression of multidrug resistance gene mdr1 mRNA in a subset of normal bone marrow cells

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12 December 2020

Elevated level of nuclear protein kinase C in multidrug-resistant MCF-7 human breast carcinoma cells

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12 December 2020

The human multidrug resistance gene: sequences upstream and downstream of the initiation site influence transcription

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12 December 2020

Monoclonal antibodies to human DNA topoisomerase I and the two isoforms of DNA topoisomerase II: 170- and 180-kDa isozymes

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12 December 2020

Biological characterization of multidrug-resistant human colon carcinoma sublines induced/selected by two methods

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12 December 2020

L-histidinol in experimental cancer chemotherapy: improving the selectivity and efficacy of anticancer drugs, eliminating metastatic disease and reversing the multidrug-resistant phenotype

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12 December 2020

Modulation of multidrug-resistant multiple myeloma by cyclosporin. The Leukaemia Group of the EORTC and the HOVON

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12 December 2020

Expression of glutathione-S-transferase-pi in human tumours.

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12 December 2020

Immunohistochemical identification of P-glycoprotein in previously untreated, diffuse large cell and immunoblastic lymphomas

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12 December 2020

Multiple drug-resistance in variant of a human non-small cell lung carcinoma cell line, DLKP-A

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12 December 2020

Biosynthesis, processing and half-life of P-glycoprotein in a human multidrug-resistant KB cell

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12 December 2020

Is the multidrug transporter a flippase?

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12 December 2020

Expression of a human complementary DNA for the multidrug resistance gene in murine hematopoietic precursor cells with the use of retroviral gene transfer.

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12 December 2020

Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells. Evidence that distinct P-glycoprotein precursors are encoded by unique mdr genes

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12 December 2020

Genetic transfer of non-P-glycoprotein-mediated multidrug resistance (MDR) in somatic cell fusion: dissection of a compound MDR phenotype

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12 December 2020

Preliminary studies of a monoclonal antibody raised to the over expressed plasma membrane associated glycoprotein of a multidrug resistant cell line

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12 December 2020

The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles.

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12 December 2020

Drug resistance to cis-diamminedichloroplatinum (II) in Chinese hamster ovary cell lines transfected with glutathione S-transferase pi gene

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12 December 2020

Clinical correlates of MDR1 (P-glycoprotein) gene expression in ovarian and small-cell lung carcinomas

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12 December 2020

Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues. Analysis with 3 monoclonal antibodies recognizing different epitopes of the P-glycoprotein molecule

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12 December 2020

Doxorubicin inhibits human DNA topoisomerase I

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12 December 2020

Cross-resistance and glutathione-S-transferase-pi levels among four human melanoma cell lines selected for alkylating agent resistance

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12 December 2020

The hypersensitivity of the Chinese hamster ovary variant BL-10 to bleomycin killing is due to a lack of glutathione S-transferase-alpha activity

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12 December 2020

Increased ATP requirement for activity of and complex formation by DNA topoisomerase II from human leukemic CCRF-CEM cells selected for resistance to teniposide

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12 December 2020

DNA-mediated transfer and cloning of a human multidrug-resistant gene of adriamycin-resistant myelogenous leukemia K562.

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12 December 2020

The role of the MDR1 (P-glycoprotein) gene in multidrug resistance in vitro and in vivo

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12 December 2020

The biochemistry of P-glycoprotein-mediated multidrug resistance

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12 December 2020

A distinct human testis and brain mu-class glutathione S-transferase. Molecular cloning and characterization of a form present even in individuals lacking hepatic type mu isoenzymes

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12 December 2020

Energy-dependent processes involved in reduced drug accumulation in multidrug-resistant human lung cancer cell lines without P-glycoprotein expression

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12 December 2020

Mechanisms of multidrug resistance in cancer treatment

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12 December 2020

Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer cell line

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12 December 2020

Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells

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12 December 2020

Modulation of activity of the promoter of the human MDR1 gene by Ras and p53.

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12 December 2020

Glutathione-S-transferase pi as a determinant of drug resistance in transfectant cell lines

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12 December 2020

Unknotting the complexities of multidrug resistance: the involvement of DNA topoisomerases in drug action and resistance.

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12 December 2020

An evaluation of the role of glutathione and its associated enzymes in the expression of differential sensitivities to antitumour agents shown by a range of human tumour cell lines.

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12 December 2020

Effect of buthionine sulfoximine on toxicity of verapamil and doxorubicin to multidrug resistant cells and to mice

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12 December 2020

Quantitative expression patterns of multidrug-resistance P-glycoprotein (MDR1) and differentially spliced cystic-fibrosis transmembrane-conductance regulator mRNA transcripts in human epithelia

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12 December 2020

Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins

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12 December 2020

Alterations in glutathione and glutathione-related enzymes in a multidrug-resistant small cell lung cancer cell line

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12 December 2020

Potentiation of doxorubicin cytotoxicity by buthionine sulfoximine in multidrug-resistant human breast tumor cells.

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12 December 2020

Reversal of Vinca alkaloid resistance by anti-P-glycoprotein monoclonal antibody HYB-241 in a human tumor xenograft

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12 December 2020

Structure of an mdr-like gene from Arabidopsis thaliana. Evolutionary implications.

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12 December 2020

Correlation between reversing of multidrug resistance and inhibiting of [3H]azidopine photolabeling of P-glycoprotein by newly synthesized dihydropyridine analogues in a human cell line.

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12 December 2020

Decreased DNA topoisomerase II in daunorubicin-resistant Ehrlich ascites tumor cells

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12 December 2020

Expression of mdr1 and mdr3 multidrug-resistance genes in human acute and chronic leukemias and association with stimulation of drug accumulation by cyclosporine

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12 December 2020

Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.

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12 December 2020

Chromosomal location of human P-glycoprotein gene sequences.

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12 December 2020

Isolation and characterization of putative intrinsic multidrug resistant Chinese hamster ovary cells by fluorescence activated cell sorting

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12 December 2020

Confluence-dependent resistance in human colon cancer cells: role of reduced drug accumulation and low intrinsic chemosensitivity of resting cells

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12 December 2020

Coinduction of MDR-1 multidrug-resistance and cytochrome P-450 genes in rat liver by xenobiotics.

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12 December 2020

Amino acid substitutions in the sixth transmembrane domain of P-glycoprotein alter multidrug resistance

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12 December 2020

Acid phosphatase: endpoint for in vitro toxicity tests

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12 December 2020

Relationship between topoisomerase II level and chemosensitivity in human tumor cell lines

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12 December 2020

SDZ PSC 833, a non-immunosuppressive cyclosporine: its potency in overcoming P-glycoprotein-mediated multidrug resistance of murine leukemia

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12 December 2020

Reduced topoisomerase II and elevated alpha class glutathione S-transferase expression in a multidrug resistant CHO cell line highly cross-resistant to mitomycin C.

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12 December 2020

New mechanisms of hormone secretion: MDR-like gene products as extrusion pumps for hormones?

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12 December 2020

Peptide transport by the multidrug resistance pump

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12 December 2020

Immunohistologic localization of alpha, mu, and pi class glutathione S-transferases in human tissues.

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12 December 2020

Structure of the human MDR3 gene and physical mapping of the human MDR locus

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12 December 2020

P-glycoprotein gene (MDR1) cDNA from human adrenal: normal P-glycoprotein carries Gly185 with an altered pattern of multidrug resistance.

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12 December 2020

Attenuated topoisomerase II content directly correlates with a low level of drug resistance in a Chinese hamster ovary cell line

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12 December 2020

Human hepatocellular carcinoma cell lines exhibit multidrug resistance unrelated to MRD1 gene expression

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12 December 2020

Modulation of multidrug resistance by verapamil or mdr1 anti-sense oligodeoxynucleotide does not change the high susceptibility to lymphokine-activated killers in mdr-resistant human carcinoma (LoVo) line.

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12 December 2020

Genetics of multidrug resistance: relationship of a cloned gene to the complete multidrug resistant phenotype.

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12 December 2020

Glutathione S-transferases and glutathione peroxidases in doxorubicin-resistant murine leukemic P388 cells.

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12 December 2020

Various methods of analysis of mdr-1/P-glycoprotein in human colon cancer cell lines

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12 December 2020

Overexpression of glutathione S-transferase and elevation of thiol pools in a multidrug-resistant human colon cancer cell line

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12 December 2020

Resistance to drugs associated with the multidrug resistance phenotype following selection with high-concentration methotrexate

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12 December 2020

Topoisomerase II alpha and topoisomerase II beta genes: characterization and mapping to human chromosomes 17 and 3, respectively

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12 December 2020

Altered regulation of P-450IA1 expression in a multidrug-resistant MCF-7 human breast cancer cell line.

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12 December 2020

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

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12 December 2020

DNA topoisomerase poisons as antitumor drugs

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12 December 2020

The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein

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12 December 2020

DNA topoisomerases in chemotherapy

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12 December 2020

Relationship of VP-16 to the classical multidrug resistance phenotype

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12 December 2020

Characterization of the multidrug resistance protein expressed in cell clones stably transfected with the mouse mdr1 cDNA.

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12 December 2020

A lack of detectable modification of topoisomerase II activity in a series of human tumor cell lines expressing only low levels of etoposide resistance

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12 December 2020

Cystic fibrosis: molecular biology and therapeutic implications

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12 December 2020

Non-P-glycoprotein-mediated multidrug resistance in a small cell lung cancer cell line: evidence for decreased susceptibility to drug-induced DNA damage and reduced levels of topoisomerase II.

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12 December 2020

Analysis of the Chinese hamster P-glycoprotein/multidrug resistance gene pgp1 reveals that the AP-1 site is essential for full promoter activity

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12 December 2020

Mechanisms of resistance to etoposide and teniposide in acquired resistant human colon and lung carcinoma cell lines

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12 December 2020

Glutathione S-transferase and glutathione peroxidase expression in normal and tumour human tissues

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12 December 2020

Involvement of Vacuolar H+-Adenosine Triphosphatase Activity in Multidrug Resistance in HL60 Cells

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12 December 2020

Glutathione S-transferases: role in alkylating agent resistance and possible target for modulation chemotherapy--a review.

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12 December 2020

The products of the mdr1a and mdr1b genes from multidrug resistant murine cells have similar degradation rates

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12 December 2020

Evidence for linear extrachromosomal elements mediating gene amplification in the multidrug-resistant J774.2 murine cell line

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12 December 2020

Progesterone interacts with P-glycoprotein in multidrug-resistant cells and in the endometrium of gravid uterus

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12 December 2020

Expression of a mutant DNA topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide

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12 December 2020

Expression of human mu or alpha class glutathione S-transferases in stably transfected human MCF-7 breast cancer cells: effect on cellular sensitivity to cytotoxic agents

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12 December 2020

Proliferation-dependent topoisomerase II content as a determinant of antineoplastic drug action in human, mouse, and Chinese hamster ovary cells

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12 December 2020

Thiol manipulation as a means of overcoming drug resistance in a novel cyclophosphamide-induced resistant cell line

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12 December 2020

Multifactorial mechanisms associated with broad cross-resistance of ovarian carcinoma cells selected by cyanomorpholino doxorubicin

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12 December 2020

Identifiers

DOI

10.1007/BF02634176

1 reference

23 September 2017

1 reference

PubMed ID

8096505