(Q40733277)

23 September 2017

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title

The cell cycle and the retinoblastoma protein family (English)

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23 September 2017

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M E Ewen

1

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PubMed ID

8143345

23 September 2017

language of work or name

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1 March 1994

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Cancer and Metastasis Reviews

23 September 2017

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23 September 2017

13

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23 September 2017

1

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23 September 2017

45-66

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https://scigraph.springernature.com/pub.10.1007/bf00690418

23 September 2017

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cites work

Human DNA polymerase alpha gene: sequences controlling expression in cycling and serum-stimulated cells

1 reference

https://api.crossref.org/works/10.1007%2FBF00690418

Transcription factor E2F is required for efficient expression of the hamster dihydrofolate reductase gene in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00690418

The HIP1 binding site is required for growth regulation of the dihydrofolate reductase gene promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00690418

The retinoblastoma protein physically associates with the human cdc2 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF00690418

Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen

21 January 2018

1 reference

12 December 2020

Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product

1 reference

12 December 2020

Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation

1 reference

12 December 2020

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1 reference

12 December 2020

D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA

1 reference

12 December 2020

1 reference

12 December 2020

Hyperphosphorylation of the retinoblastoma gene product is determined by domains outside the simian virus 40 large-T-antigen-binding regions

1 reference

12 December 2020

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

1 reference

12 December 2020

Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene

1 reference

12 December 2020

Adenovirus E1A is associated with a serine/threonine protein kinase

1 reference

12 December 2020

Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner

1 reference

12 December 2020

Multiple functional domains in the adenovirus E1A gene

1 reference

12 December 2020

Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma

1 reference

12 December 2020

Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells.

1 reference

12 December 2020

A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway

1 reference

12 December 2020

Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F.

1 reference

12 December 2020

Regions controlling hyperphosphorylation and conformation of the retinoblastoma gene product are independent of domains required for transcriptional repression

1 reference

12 December 2020

Structural evidence for the authenticity of the human retinoblastoma gene

1 reference

12 December 2020

Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle

1 reference

12 December 2020

Cell cycle regulation of histone H1 kinase activity associated with the adenoviral protein E1A.

1 reference

12 December 2020

Point mutational inactivation of the retinoblastoma antioncogene

1 reference

12 December 2020

Somatic inactivation of genes on chromosome 13 is a common event in retinoblastoma

1 reference

12 December 2020

A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter

1 reference

12 December 2020

TGF beta inhibition of Cdk4 synthesis is linked to cell cycle arrest

1 reference

12 December 2020

Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation

1 reference

12 December 2020

Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein

1 reference

12 December 2020

Distinct, essential roles of type 1 and 2A protein phosphatases in the control of the fission yeast cell division cycle.

1 reference

12 December 2020

Genomic organization, chromosomal localization, and independent expression of human cyclin D genes

1 reference

12 December 2020

Interactions of the p107 and Rb proteins with E2F during the cell proliferation response

1 reference

12 December 2020

Deletion of a splice donor site ablates expression of the following exon and produces an unphosphorylated RB protein unable to bind SV40 T antigen

1 reference

12 December 2020

Interaction between human cyclin A and adenovirus E1A-associated p107 protein

1 reference

12 December 2020

The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity

1 reference

12 December 2020

Growth inhibition by TGF-beta linked to suppression of retinoblastoma protein phosphorylation

1 reference

12 December 2020

The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus

1 reference

12 December 2020

Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product

1 reference

12 December 2020

Universal control mechanism regulating onset of M-phase

1 reference

12 December 2020

Cellular targets for transformation by the adenovirus E1A proteins

1 reference

12 December 2020

The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F

1 reference

12 December 2020

Adenovirus E1a prevents the retinoblastoma gene product from complexing with a cellular transcription factor

1 reference

12 December 2020

Retinoblastoma protein switches the E2F site from positive to negative element

1 reference

12 December 2020

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1 reference

12 December 2020

Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeast

1 reference

12 December 2020

Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product

1 reference

12 December 2020

Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts

1 reference

12 December 2020

Effects of an Rb mutation in the mouse

1 reference

12 December 2020

Human retinoblastoma susceptibility gene: cloning, identification, and sequence.

1 reference

12 December 2020

cdc2 is a component of the M phase-specific histone H1 kinase: evidence for identity with MPF

1 reference

12 December 2020

Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts

1 reference

12 December 2020

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1 reference

12 December 2020

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1 reference

12 December 2020

E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor

1 reference

12 December 2020

E2F: a link between the Rb tumor suppressor protein and viral oncoproteins

1 reference

12 December 2020

Independent regulation of human D-type cyclin gene expression during G1 phase in primary human T lymphocytes

1 reference

12 December 2020

The NFAT-1 DNA binding complex in activated T cells contains Fra-1 and JunB.

1 reference

12 December 2020

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

1 reference

12 December 2020

Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells

1 reference

12 December 2020

Integration of Friend murine leukemia virus into both alleles of the p53 oncogene in an erythroleukemic cell line

1 reference

12 December 2020

A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1

1 reference

12 December 2020

The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle

1 reference

12 December 2020

A region of SV40 large T antigen can substitute for a transforming domain of the adenovirus E1A products

1 reference

12 December 2020

The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines

1 reference

12 December 2020

Changes in growth and tumorigenicity following reconstitution of retinoblastoma gene function in various human cancer cell types by microcell transfer of chromosome 13

1 reference

12 December 2020

G1 events and regulation of cell proliferation

1 reference

12 December 2020

The transforming growth factor-beta family

1 reference

12 December 2020

Transcription factor E2F binds DNA as a heterodimer

1 reference

12 December 2020

SV40 T antigen binds specifically to a cellular 53 K protein in vitro

1 reference

12 December 2020

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product

1 reference

12 December 2020

Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering

1 reference

12 December 2020

Physical interaction of the retinoblastoma protein with human D cyclins

1 reference

12 December 2020

In vitro phosphorylation of the tumor suppressor gene RB protein by mitosis-specific histone H1 kinase

1 reference

12 December 2020

In vitro mutagenesis of a putative DNA binding domain of SV40 large-T

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12 December 2020

Cyclin A is required in S phase in normal epithelial cells.

1 reference

12 December 2020

A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene product

1 reference

12 December 2020

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein

1 reference

12 December 2020

Transforming growth factor-beta inhibits phosphorylation of the retinoblastoma susceptibility gene product in human monocytic leukemia cell line JOSK-I.

1 reference

12 December 2020

Functional domains of adenovirus type 5 E1a proteins.

1 reference

12 December 2020

Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family.

1 reference

12 December 2020

Negative regulation of human c-fos expression by the retinoblastoma gene product

1 reference

12 December 2020

The E2F transcription factor is a cellular target for the RB protein

1 reference

12 December 2020

Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: a novel mechanism for E1A trans-activation

1 reference

12 December 2020

Oncogenic activation of cyclin A.

1 reference

12 December 2020

Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product

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12 December 2020

Early gene responses to transforming growth factor-beta in cells lacking growth-suppressive RB function

1 reference

12 December 2020

Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle

1 reference

12 December 2020

Absence of TGF-beta receptors and growth inhibitory responses in retinoblastoma cells

1 reference

12 December 2020

Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B.

1 reference

12 December 2020

Tumor suppressor genes

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12 December 2020

Nuclear Binding of Purified Retinoblastoma Gene Product Is Determined by Cell Cycle-Regulated Phosphorylation

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12 December 2020

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1 reference

12 December 2020

Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene.

1 reference

12 December 2020

C-terminal truncation of the retinoblastoma gene product leads to functional inactivation

1 reference

12 December 2020

Protein phosphatase type 1 in mammalian cell mitosis: chromosomal localization and involvement in mitotic exit

1 reference

12 December 2020

Co-purification of p34cdc2/p58cyclin A proline-directed protein kinase and the retinoblastoma tumor susceptibility gene product: interaction of an oncogenic serine/threonine protein kinase with a tumor-suppressor protein

1 reference

12 December 2020

Cell cycle regulation of the human cdc2 gene

1 reference

12 December 2020

Mutation and cancer: statistical study of retinoblastoma

1 reference

12 December 2020

The release of growth arrest by microinjection of adenovirus E1A DNA.

1 reference

12 December 2020

An N-terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110Rb and a second cellular protein, p120.

1 reference

12 December 2020

The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

1 reference

12 December 2020

Retinoblastoma gene product activates expression of the human TGF-β2 gene through transcription factor ATF-2

1 reference

12 December 2020

Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins

1 reference

12 December 2020

Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase

1 reference

12 December 2020

Requirement for a functional Rb-1 gene in murine development

1 reference

12 December 2020

Cyclin a is required for the onset of DNA replication in mammalian fibroblasts

1 reference

12 December 2020

Binding of the Rb1 protein to E1A products is required for adenovirus transformation

1 reference

12 December 2020

A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding

1 reference

12 December 2020

Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts

1 reference

12 December 2020

The p53 proto-oncogene can act as a suppressor of transformation

1 reference

12 December 2020

Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein

1 reference

12 December 2020

The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit

1 reference

12 December 2020

Association of human cyclin E with a periodic G1-S phase protein kinase

1 reference

12 December 2020

The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations

1 reference

12 December 2020

Identification of a 70-base-pair cell cycle regulatory unit within the promoter of the human thymidine kinase gene and its interaction with cellular factors

1 reference

12 December 2020

Suppression of growth factor-induced CYL1 cyclin gene expression by antiproliferative agents

1 reference

12 December 2020

A- and B-type cyclins differentially modulate substrate specificity of cyclin-cdk complexes

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12 December 2020

When the products of oncogenes and anti-oncogenes meet

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12 December 2020

Cell cycle analysis of E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F.

1 reference

12 December 2020

A general theory of carcinogenesis

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12 December 2020

Thymidine kinase transcription is regulated at G1/S phase by a complex that contains retinoblastoma-like protein and a cdc2 kinase

1 reference

12 December 2020

TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains.

1 reference

12 December 2020

Factor-binding element in the human c-myc promoter involved in transcriptional regulation by transforming growth factor beta 1 and by the retinoblastoma gene product

1 reference

12 December 2020

SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family

1 reference

12 December 2020

A new component of the transcription factor DRTF1/E2F.

1 reference

12 December 2020

CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle

1 reference

12 December 2020

Identification of a growth suppression domain within the retinoblastoma gene product

1 reference

12 December 2020

A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells

1 reference

12 December 2020

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1 reference

12 December 2020

Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes

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12 December 2020

Stability of retinoblastoma gene expression determines the tumorigenicity of reconstituted retinoblastoma cells

1 reference

12 December 2020

Loss of a highly conserved domain on p53 as a result of gene deletion during Friend virus-induced erythroleukemia

1 reference

12 December 2020

Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F

1 reference

12 December 2020

The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A.

1 reference

12 December 2020

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

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12 December 2020

Role for cyclin A in the dependence of mitosis on completion of DMA replication

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12 December 2020

Association of adenovirus early-region 1A proteins with cellular polypeptides

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12 December 2020

Patient with 13 Chromosome Deletion: Evidence That the Retinoblastoma Gene Is a Recessive Cancer Gene

1 reference

12 December 2020

Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells

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12 December 2020

The retinoblastoma gene product regulates Sp1-mediated transcription

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12 December 2020

The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression

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12 December 2020

The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein

1 reference

12 December 2020

Detection of cellular proteins associated with human adenovirus type 5 early region 1A polypeptides.

1 reference

12 December 2020

Identification of separate domains in the adenovirus E1A gene for immortalization activity and the activation of virus early genes

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12 December 2020

Cyclin-dependent regulation of G1 in mammalian fibroblasts.

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12 December 2020

Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein

1 reference

12 December 2020

G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment

1 reference

12 December 2020

Osteosarcoma and retinoblastoma: a shared chromosomal mechanism revealing recessive predisposition

1 reference

12 December 2020

A novel cyclin encoded by a bcl1-linked candidate oncogene

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12 December 2020

Animal cell cycles and their control

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12 December 2020

Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product

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12 December 2020

Molecular detection of deletions involving band q14 of chromosome 13 in retinoblastomas

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12 December 2020

Cyclin D and oncogenesis

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12 December 2020

A family of human cdc2-related protein kinases

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12 December 2020

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

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12 December 2020

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

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12 December 2020

A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex.

1 reference

12 December 2020

Regulation of transforming growth factor beta 1 gene expression by the product of the retinoblastoma-susceptibility gene

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12 December 2020

E1a regions of the human adenoviruses and of the highly oncogenic simian adenovirus 7 are closely related

1 reference

12 December 2020

Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase

1 reference

12 December 2020

Gene for hereditary retinoblastoma assigned to human chromosome 13 by linkage to esterase D

1 reference

12 December 2020

Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein

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12 December 2020

Specific enzymatic dephosphorylation of the retinoblastoma protein

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12 December 2020

The retinoblastoma protein is phosphorylated on multiple sites by human cdc2

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12 December 2020

Adenovirus E1a prevents the retinoblastoma gene product from repressing the activity of a cellular transcription factor

1 reference

12 December 2020

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

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12 December 2020

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

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12 December 2020

The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T.

1 reference

12 December 2020

Prediction of similar transforming regions in simian virus 40 large T, adenovirus E1A, and myc oncoproteins

1 reference

12 December 2020

Transforming growth factor beta 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation

1 reference

12 December 2020

Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta.

1 reference

12 December 2020

Cyclin A is required at two points in the human cell cycle

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12 December 2020

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12 December 2020

Separation of simian virus 40 large-T-antigen-transforming and origin-binding functions from the ability to block differentiation

1 reference

12 December 2020

Two regions of the adenovirus early region 1A proteins are required for transformation.

1 reference

12 December 2020

The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB

1 reference

12 December 2020

Cloning of a D-type cyclin from murine erythroleukemia cells

1 reference

12 December 2020

Abrogation by c-myc of G1 phase arrest induced by RB protein but not by p53

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12 December 2020

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

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12 December 2020

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F

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12 December 2020

A cdc2-like protein is involved in the initiation of DNA replication in Xenopus egg extracts

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12 December 2020

Identification of a region of simian virus 40 large T antigen required for cell transformation

1 reference

12 December 2020

Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF00690418

1 reference

PubMed ID

8143345

Dimensions Publication ID

23 September 2017

0 references

1 reference

PubMed ID

8143345