(Q40734731)

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N-(4-hydroxyphenyl)retinamide increases ceramide and is cytotoxic to acute lymphoblastic leukemia cell lines, but not to non-malignant lymphocytes.

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10 December 2019

N-(4-hydroxyphenyl)retinamide increases ceramide and is cytotoxic to acute lymphoblastic leukemia cell lines, but not to non-malignant lymphocytes (English)

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10 December 2019

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lymphoblastic leukemia

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3

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10 December 2019

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O'Donnell PH

1

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10 December 2019

Guo WX

2

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10 December 2019

Maurer BJ

4

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10 December 2019

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1 May 2002

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10 December 2019

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10 December 2019

16

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10 December 2019

5

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10 December 2019

902-910

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10 December 2019

describes a project that uses

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Acute lymphoblastic leukemia

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Growth inhibition and induction of apoptosis by fenretinide in small-cell lung cancer cell lines.

1 reference

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7 January 2021

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Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl)- retinamide in neuroblastoma cell lines

1 reference

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7 January 2021

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Neuroblastoma cell apoptosis induced by the synthetic retinoid N-(4-hydroxyphenyl)retinamide

1 reference

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7 January 2021

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N-(4-hydroxyphenyl)retinamide: a Potent Inducer of Apoptosis in Human Neuroblastoma Cells

1 reference

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7 January 2021

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Combined effect of tamoxifen or interferon-beta and 4-hydroxyphenylretinamide on the growth of breast cancer cell lines

1 reference

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7 January 2021

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N-(4-hydroxyphenyl) retinamide induces cell cycle specific growth inhibition in PC3 cells

1 reference

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7 January 2021

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Effects of fenretinide (4-HPR) on prostate LNCaP cell growth, apoptosis, and prostate-specific gene expression

1 reference

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7 January 2021

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Induction of apoptosis by fenretinide (4HPR) in human ovarian carcinoma cells and its association with retinoic acid receptor expression

1 reference

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7 January 2021

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Retinoic acid receptor beta expression and growth inhibition of gynecologic cancer cells by the synthetic retinoid N-(4-hydroxyphenyl) retinamide

1 reference

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7 January 2021

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Involvement of reactive oxygen species in N-(4-hydroxyphenyl)retinamide-induced apoptosis in cervical carcinoma cells

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

N-(4-hydroxyphenyl)retinamide-induced death in human lymphoblastoid cells: 50 kb DNA breakage as a means of distinguishing apoptosis from necrosis

1 reference

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7 January 2021

based on heuristic

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N-(4-hydroxyphenyl)retinamide induces apoptosis in T lymphoma and T lymphoblastoid leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Phase I/II trial of tamoxifen with or without fenretinide, an analog of vitamin A, in women with metastatic breast cancer

1 reference

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7 January 2021

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Phase IIa study of fenretinide in superficial bladder cancer, using DNA flow cytometry as an intermediate end point

1 reference

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7 January 2021

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Successful topical treatment of oral lichen planus and leukoplakias with fenretinide (4-HPR)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of antioxidants and intracellular free radicals in retinamide-induced cell death.

1 reference

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7 January 2021

based on heuristic

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Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of G1/S transition and induction of apoptosis in HL-60 leukemia cells by fenretinide (4HPR)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

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Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

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Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Signal transduction of stress via ceramide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of ceramide production and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Glucosylceramide synthase: assay and properties

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

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Purification and characterization of 1-O-acylceramide synthase, a novel phospholipase A2 with transacylase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibitors of glucosylceramide synthase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Improved Inhibitors of Glucosylceramide Synthase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

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The C.B.17 scid mouse strain as a model for human disseminated leukaemia and myeloma in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

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Sensitivity of cultured human lymphoblasts (CCRF-CEM cells) to inhibition by thymidine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Analysis of human leukemia/lymphoma cell lines with monoclonal antibodies BA-1, BA-2 and BA-3

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Human leukemic “null” cell line (NALL-1)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Alternative splicing of the p53 tumor suppressor gene in the Molt-4 T-lymphoblastic leukemia cell line

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Accumulation of glucosylceramides in multidrug-resistant cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Ceramide synthase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Serine palmitoyltransferase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Drug combinations: from laboratory to practice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Enzymes of ceramide biosynthesis

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of cytotoxicity induced by sphingolipids in multidrug-resistant leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Cytotoxic effects of sphingolipids as single or multi-modality agents on human melanoma and soft tissue sarcoma in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

inferred from DOI database lookup

Glucosylceramide synthase does not attenuate the ceramide pool accumulating during apoptosis induced by CD95 or anti-cancer regimens

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485

7 January 2021

based on heuristic

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Identifiers

10.1038/SJ.LEU.2402485

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11986953%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11986953%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

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