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N-(4-hydroxyphenyl)retinamide increases ceramide and is cytotoxic to acute lymphoblastic leukemia cell lines, but not to non-malignant lymphocytes.
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1 reference
stated in
Europe PubMed Central
PubMed publication ID
11986953
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11986953%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
title
N-(4-hydroxyphenyl)retinamide increases ceramide and is cytotoxic to acute lymphoblastic leukemia cell lines, but not to non-malignant lymphocytes
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11986953
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11986953%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
main subject
cell line
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cytotoxicity
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lymphocyte
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leukemia
1 reference
based on heuristic
inferred from title
ceramides
1 reference
based on heuristic
inferred from title
lymphoblastic leukemia
1 reference
based on heuristic
inferred from title
author
C P Reynolds
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11986953
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11986953%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
author name string
O'Donnell PH
series ordinal
1
1 reference
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Europe PubMed Central
PubMed publication ID
11986953
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11986953%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
Guo WX
series ordinal
2
1 reference
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Europe PubMed Central
PubMed publication ID
11986953
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11986953%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
Maurer BJ
series ordinal
4
1 reference
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Europe PubMed Central
PubMed publication ID
11986953
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11986953%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
publication date
1 May 2002
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11986953
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11986953%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
published in
Leukemia
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11986953
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11986953%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
volume
16
1 reference
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Europe PubMed Central
PubMed publication ID
11986953
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11986953%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
issue
5
1 reference
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Europe PubMed Central
PubMed publication ID
11986953
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11986953%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
page(s)
902-910
1 reference
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Europe PubMed Central
PubMed publication ID
11986953
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11986953%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
describes a project that uses
MOLT-3
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MOLT-4
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NALL-1
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NALM-6
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SMS-SAL
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SMS-SB
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exact match
https://scigraph.springernature.com/pub.10.1038/sj.leu.2402485
0 references
cites work
Acute lymphoblastic leukemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Growth inhibition and induction of apoptosis by fenretinide in small-cell lung cancer cell lines.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl)- retinamide in neuroblastoma cell lines
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neuroblastoma cell apoptosis induced by the synthetic retinoid N-(4-hydroxyphenyl)retinamide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
N-(4-hydroxyphenyl)retinamide: a Potent Inducer of Apoptosis in Human Neuroblastoma Cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Combined effect of tamoxifen or interferon-beta and 4-hydroxyphenylretinamide on the growth of breast cancer cell lines
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
N-(4-hydroxyphenyl) retinamide induces cell cycle specific growth inhibition in PC3 cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of fenretinide (4-HPR) on prostate LNCaP cell growth, apoptosis, and prostate-specific gene expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of apoptosis by fenretinide (4HPR) in human ovarian carcinoma cells and its association with retinoic acid receptor expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Retinoic acid receptor beta expression and growth inhibition of gynecologic cancer cells by the synthetic retinoid N-(4-hydroxyphenyl) retinamide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Involvement of reactive oxygen species in N-(4-hydroxyphenyl)retinamide-induced apoptosis in cervical carcinoma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
N-(4-hydroxyphenyl)retinamide-induced death in human lymphoblastoid cells: 50 kb DNA breakage as a means of distinguishing apoptosis from necrosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
N-(4-hydroxyphenyl)retinamide induces apoptosis in T lymphoma and T lymphoblastoid leukemia cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase I/II trial of tamoxifen with or without fenretinide, an analog of vitamin A, in women with metastatic breast cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phase IIa study of fenretinide in superficial bladder cancer, using DNA flow cytometry as an intermediate end point
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Successful topical treatment of oral lichen planus and leukoplakias with fenretinide (4-HPR)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of antioxidants and intracellular free radicals in retinamide-induced cell death.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synergistic cytotoxicity in solid tumor cell lines between N-(4-hydroxyphenyl)retinamide and modulators of ceramide metabolism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of G1/S transition and induction of apoptosis in HL-60 leukemia cells by fenretinide (4HPR)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Signal transduction of stress via ceramide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of ceramide production and apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Glucosylceramide synthase: assay and properties
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Purification and characterization of 1-O-acylceramide synthase, a novel phospholipase A2 with transacylase activity.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibitors of glucosylceramide synthase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Improved Inhibitors of Glucosylceramide Synthase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The C.B.17 scid mouse strain as a model for human disseminated leukaemia and myeloma in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sensitivity of cultured human lymphoblasts (CCRF-CEM cells) to inhibition by thymidine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Analysis of human leukemia/lymphoma cell lines with monoclonal antibodies BA-1, BA-2 and BA-3
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human leukemic “null” cell line (NALL-1)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Alternative splicing of the p53 tumor suppressor gene in the Molt-4 T-lymphoblastic leukemia cell line
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Accumulation of glucosylceramides in multidrug-resistant cancer cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ceramide synthase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Serine palmitoyltransferase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Drug combinations: from laboratory to practice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enzymes of ceramide biosynthesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of cytotoxicity induced by sphingolipids in multidrug-resistant leukemia cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cytotoxic effects of sphingolipids as single or multi-modality agents on human melanoma and soft tissue sarcoma in vitro
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Glucosylceramide synthase does not attenuate the ceramide pool accumulating during apoptosis induced by CD95 or anti-cancer regimens
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.LEU.2402485
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/SJ.LEU.2402485
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11986953
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11986953%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
Dimensions Publication ID
1026963025
0 references
PubMed publication ID
11986953
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11986953
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11986953%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 December 2019
ResearchGate publication ID
11383039
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