(Q40741484)

English

A proximal promoter domain containing a homeodomain-binding core motif interacts with multiple transcription factors, including HoxA5 and Phox2 proteins, and critically regulates cell type-specific transcription of the human norepinephrine transport

scientific article published on April 2002

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scholarly article

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8 December 2019

A proximal promoter domain containing a homeodomain-binding core motif interacts with multiple transcription factors, including HoxA5 and Phox2 proteins, and critically regulates cell type-specific transcription of the human norepinephrine transporter gene (English)

1 reference

Europe PubMed Central

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8 December 2019

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author name string

Chun-Hyung Kim

1

1 reference

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8 December 2019

Dong-Youn Hwang

2

1 reference

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8 December 2019

Jae-Joon Park

3

1 reference

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8 December 2019

Kwang-Soo Kim

4

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8 December 2019

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publication date

1 April 2002

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8 December 2019

Journal of Neuroscience

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8 December 2019

22

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8 December 2019

7

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8 December 2019

2579-2589

1 reference

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8 December 2019

Paired-like homeodomain proteins, Phox2a and Phox2b, are responsible for noradrenergic cell-specific transcription of the dopamine beta-hydroxylase gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5' flanking sequences of the rat tyrosine hydroxylase gene target accurate tissue-specific, developmental, and transsynaptic expression in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cooperation by sterol regulatory element-binding protein and Sp1 in sterol regulation of low density lipoprotein receptor gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of norepinephrine in the pathophysiology and treatment of mood disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple protein factors interact with the cis-regulatory elements of the proximal promoter in a cell-specific manner and regulate transcription of the dopamine beta-hydroxylase gene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Hox-1.3 homeo box protein is a sequence-specific DNA-binding phosphoprotein

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Noradrenaline transporter expression in the pons and medulla oblongata of the rat: localisation to noradrenergic and some C1 adrenergic neurones.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A bifunctional genetic regulatory element of the rat dopamine beta-hydroxylase gene influences cell type specificity and second messenger-mediated transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of the noradrenaline transporter in adrenergic chromaffin cells, ganglion cells and nerve fibres of the rat adrenal medulla

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the acute and chronic effects of reboxetine on extracellular noradrenaline and other monoamines in the rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Compromised HOXA5 function can limit p53 expression in human breast tumours

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autocrine regulation of norepinephrine transporter expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of norepinephrine and serotonin transporter mRNAs in the rat superior cervical ganglion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

5' upstream DNA sequence of the rat tyrosine hydroxylase gene directs high-level and tissue-specific expression to catecholaminergic neurons in the central nervous system of transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Uptake, Storage, Release and Metabolism of Noradrenaline in Sympathetic Nerves

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and characterization of potential cis-regulatory elements governing transcriptional activation of the rat tyrosine hydroxylase gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Noradrenergic-specific transcription of the dopamine beta-hydroxylase gene requires synergy of multiple cis-acting elements including at least two Phox2a-binding sites.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and expression of the bovine sodium- and chloride-dependent noradrenaline transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversal by imipramine of beta-adrenoceptor up-regulation induced in a chronic mild stress model of depression

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunolocalization of the cocaine- and antidepressant-sensitive l-norepinephrine transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-type-specific expression of catecholamine transporters in the rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recognition Sites for Norepinephrine Uptake: Regulation by Neurotransmitter

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agonist binding to alpha 2-adrenoceptors is elevated in the locus coeruleus from victims of suicide

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An Improved strategy for rapid direct sequencing of both strands of long DNA molecules cloned in a plasmid

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of norepinephrine in the pathophysiology of cognitive disorders: potential applications to the treatment of cognitive dysfunction in schizophrenia and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of a Purkinje cell-specific promoter by homeodomain proteins: repression by engrailed-2 vs. synergistic activation by Hoxa5 and Hoxb7.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional dissection of the mouse Hox-a5 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential in vivo regulation of mRNA encoding the norepinephrine transporter and tyrosine hydroxylase in rat adrenal medulla and locus ceruleus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A dual role for the cAMP-dependent protein kinase in tyrosine hydroxylase gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-specific expression of the prolactin gene in transgenic mice is controlled by synergistic interactions between promoter and enhancer elements

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progressive restriction in the distribution of the Hox-1.3 homeodomain protein during embryogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defects in sensory and autonomic ganglia and absence of locus coeruleus in mice deficient for the homeobox gene Phox2a

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An E-box motif residing in the exon/intron 1 junction regulates both transcriptional activation and splicing of the human norepinephrine transporter gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuron-specific expression of the human dopamine beta-hydroxylase gene requires both the cAMP-response element and a silencer region.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HOXA5 regulates expression of the progesterone receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding sites for hepatocyte nuclear factor 3 beta or 3 gamma and pancreas transcription factor 1 are required for efficient expression of the gene encoding pancreatic alpha-amylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A high-efficiency synthetic promoter that drives transgene expression selectively in noradrenergic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A homeodomain protein selectively expressed in noradrenergic tissue regulates transcription of neurotransmitter biosynthetic genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A previously undescribed intron and extensive 5' upstream sequence, but not Phox2a-mediated transactivation, are necessary for high level cell type-specific expression of the human norepinephrine transporter gene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of a cocaine-sensitive norepinephrine transporter in the human placental syncytiotrophoblast.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The expression pattern of the transcription factor Phox2 delineates synaptic pathways of the autonomic nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The rat norepinephrine transporter: molecular cloning from PC12 cells and functional expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cAMP-dependent protein kinase regulates transcription of the dopamine beta-hydroxylase gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning and characterization of a human DNA binding factor that represses transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking the norepinephrine transporter are supersensitive to psychostimulants

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cooperation between elements of an organ-specific transcriptional enhancer in animals

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A far-downstream hepatocyte-specific control region directs expression of the linked human apolipoprotein E and C-I genes in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-specific expression from the human dopamine beta-hydroxylase promoter in transgenic mice is controlled via a combination of positive and negative regulatory elements.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11923423

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.22-07-02579.2002

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11923423%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11923423%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11923423%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

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