(Q40775415)

23 September 2017

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title

Prediction and analysis of structure, stability and unfolding of thermolysin-like proteases (English)

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23 September 2017

G Vriend

1

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PubMed ID

8229092

23 September 2017

V Eijsink

series ordinal

2

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23 September 2017

1 August 1993

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Journal of Computer - Aided Molecular Design

23 September 2017

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23 September 2017

7

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23 September 2017

4

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23 September 2017

367-396

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https://scigraph.springernature.com/pub.10.1007/bf02337558

23 September 2017

0 references

cites work

Increasing the thermostability of the neutral proteinase of Bacillus stearothermophilus by improvement of internal hydrogen-bonding

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF02337558

Kinetics of tryptic hydrolysis of the arginine-valine bond in folded and unfolded ribonuclease T1.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF02337558

A correlation between protein thermostability and resistance to proteolysis

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF02337558

Engineering protein thermal stability. Sequence statistics point to residue substitutions in alpha-helices.

21 January 2018

1 reference

12 December 2020

Increasing the thermostability of a neutral protease by replacing positively charged amino acids in the N-terminal turn of alpha-helices

1 reference

12 December 2020

Determinants of a protein fold. Unique features of the globin amino acid sequences

1 reference

12 December 2020

Helix signals in proteins

1 reference

12 December 2020

The role of the pro-sequence in the processing and secretion of the thermolysin-like neutral protease from Bacillus cereus

1 reference

12 December 2020

Hydrophobic packing in T4 lysozyme probed by cavity-filling mutants

1 reference

12 December 2020

One-step affinity purification of Bacillus neutral proteases using bacitracin-silica

1 reference

12 December 2020

Structure of a stabilizing disulfide bridge mutant that closes the active‐site cleft of T4 lysozyme

1 reference

12 December 2020

Amino-acid sequence of thermolysin

1 reference

12 December 2020

Prediction of the folding of short polypeptide segments by uniform conformational sampling

1 reference

12 December 2020

Tertiary templates for proteins. Use of packing criteria in the enumeration of allowed sequences for different structural classes

1 reference

12 December 2020

Effect of cavity-modulating mutations on the stability of Escherichia coli ribonuclease HI

1 reference

12 December 2020

Thermal stability and protein structure

1 reference

12 December 2020

Strength and co-operativity of contributions of surface salt bridges to protein stability

1 reference

12 December 2020

The alpha-helix dipole and the properties of proteins

1 reference

12 December 2020

Contributions of engineered surface salt bridges to the stability of T4 lysozyme determined by directed mutagenesis

1 reference

12 December 2020

Comparison of the structures of carboxypeptidase A and thermolysin

1 reference

12 December 2020

Effect of alanine versus glycine in alpha-helices on protein stability

1 reference

12 December 2020

Prediction of protein folding from amino acid sequence over discrete conformation spaces

1 reference

12 December 2020

Toward a simplification of the protein folding problem: a stabilizing polyalanine alpha-helix engineered in T4 lysozyme

1 reference

12 December 2020

Knowledge-based prediction of protein structures and the design of novel molecules

1 reference

12 December 2020

Internal cavities and buried waters in globular proteins.

1 reference

12 December 2020

Capping and alpha-helix stability

1 reference

12 December 2020

WHAT IF: a molecular modeling and drug design program

1 reference

12 December 2020

pH-induced denaturation of proteins: a single salt bridge contributes 3-5 kcal/mol to the free energy of folding of T4 lysozyme

1 reference

12 December 2020

Stabilization by a disulfide bond of the N-terminal domain of a mutant troponin C (TnC48/82).

1 reference

12 December 2020

Analysis and modulation of protein stability

1 reference

12 December 2020

Crystal structure of neutral protease from Bacillus cereus refined at 3.0 A resolution and comparison with the homologous but more thermostable enzyme thermolysin

1 reference

12 December 2020

Proteolytic specificity of the neutral zinc proteinase from Bacillus mesentericus strain 76 determined by digestion of an alpha-globin chain.

1 reference

12 December 2020

Enhanced protein thermostability from designed mutations that interact with alpha-helix dipoles

1 reference

12 December 2020

Energetic contribution of solvent-exposed ion pairs to alpha-helix structure

1 reference

12 December 2020

Structure of thermolysin refined at 1.6 A resolution

1 reference

12 December 2020

Glycine to alanine substitutions in helices of glyceraldehyde-3-phosphate dehydrogenase: effects on stability.

1 reference

12 December 2020

The primary structure of Bacillus cereus neutral proteinase and comparison with thermolysin and Bacillus subtilis neutral proteinase

1 reference

12 December 2020

Applications of thermolysin in protein structural analysis

1 reference

12 December 2020

Conformational stability and activity of ribonuclease T1 with zero, one, and two intact disulfide bonds

1 reference

12 December 2020

Predicting antibody hypervariable loop conformations. II: Minimization and molecular dynamics studies of MCPC603 from many randomly generated loop conformations

1 reference

12 December 2020

Evolution and the tertiary structure of proteins

1 reference

12 December 2020

Influence of interior packing and hydrophobicity on the stability of a protein.

1 reference

12 December 2020

The effect of cavity-filling mutations on the thermostability of Bacillus stearothermophilus neutral protease

1 reference

12 December 2020

Secondary structure-based profiles: use of structure-conserving scoring tables in searching protein sequence databases for structural similarities

1 reference

12 December 2020

Criteria that discriminate between native proteins and incorrectly folded models

1 reference

12 December 2020

Effects of engineered salt bridges on the stability of subtilisin BPN'

1 reference

12 December 2020

Thermostability of Bacillus subtilis neutral protease

1 reference

12 December 2020

Protein structure. Prediction of progress at last.

1 reference

12 December 2020

Mapping transition states of protein unfolding by protein engineering of ligand-binding sites

1 reference

12 December 2020

A mutant T4 lysozyme (Val 131----Ala) designed to increase thermostability by the reduction of strain within an alpha-helix

1 reference

12 December 2020

1 reference

12 December 2020

Structure and stability of thermophilic enzymes. Studies on thermolysin

1 reference

12 December 2020

Atomic size packing defects in proteins

1 reference

12 December 2020

Thermal motions of surface alpha-helices in the D-galactose chemosensory receptor. Detection by disulfide trapping

1 reference

12 December 2020

Contributions of the large hydrophobic amino acids to the stability of staphylococcal nuclease

1 reference

12 December 2020

Mapping the transition state and pathway of protein folding by protein engineering

1 reference

12 December 2020

The structural stability of a protein is an important determinant of its proteolytic susceptibility in Escherichia coli

1 reference

12 December 2020

Enhancement of the thermostability of subtilisin E by introduction of a disulfide bond engineered on the basis of structural comparison with a thermophilic serine protease

1 reference

12 December 2020

Genes for alkaline protease and neutral protease from Bacillus amyloliquefaciens contain a large open reading frame between the regions coding for signal sequence and mature protein

1 reference

12 December 2020

Physical reasons for secondary structure stability: alpha-helices in short peptides

1 reference

12 December 2020

Environment-specific amino acid substitution tables: tertiary templates and prediction of protein folds

1 reference

12 December 2020

Amino acid preferences for specific locations at the ends of alpha helices

1 reference

12 December 2020

Characterization of the transition state of lysozyme unfolding. I. Effect of protein-solvent interactions on the transition state

1 reference

12 December 2020

Alternative packing arrangements in the hydrophobic core of λrepresser

1 reference

12 December 2020

Replacements of Pro86 in phage T4 lysozyme extend an alpha-helix but do not alter protein stability

1 reference

12 December 2020

Protein engineering of subtilisin BPN': enhanced stabilization through the introduction of two cysteines to form a disulfide bond

1 reference

12 December 2020

A method to configure protein side-chains from the main-chain trace in homology modelling

1 reference

12 December 2020

Measuring and increasing protein stability

1 reference

12 December 2020

Studies of synthetic helical peptides using circular dichroism and nuclear magnetic resonance

1 reference

12 December 2020

Contribution of hydrophobic interactions to protein stability

1 reference

12 December 2020

Assembly of polypeptide and protein backbone conformations from low energy ensembles of short fragments: Development of strategies and construction of models for myoglobin, lysozyme, and thymosin β4

1 reference

12 December 2020

Stabilization of protein structure by interaction of alpha-helix dipole with a charged side chain

1 reference

12 December 2020

A thermodynamic scale for the helix-forming tendencies of the commonly occurring amino acids

1 reference

12 December 2020

Secretion, processing and activation of bacterial extracellular proteases

1 reference

12 December 2020

Addition of a methyl group changes both the catalytic velocity and thermostability of the neutral protease from Bacillus stearothermophilus

1 reference

12 December 2020

Nucleotide sequences of genes encoding heat-stable and heat-labile glyceraldehyde-3-phosphate dehydrogenases; amino acid sequence and protein thermostability

1 reference

12 December 2020

Detection of native-like models for amino acid sequences of unknown three-dimensional structure in a data base of known protein conformations

1 reference

12 December 2020

Cloning and nucleotide sequence of the highly thermostable neutral protease gene from Bacillus stearothermophilus

1 reference

12 December 2020

Using known substructures in protein model building and crystallography

1 reference

12 December 2020

Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

12 December 2020

Stabilization of Escherichia coli ribonuclease H by introduction of an artificial disulfide bond

1 reference

12 December 2020

Role of bound calcium ions in thermostable, proteolytic enzymes. Separation of intrinsic and calcium ion contributions to the kinetic thermal stability

1 reference

12 December 2020

Conformational stability of globular proteins

1 reference

12 December 2020

The relation between the divergence of sequence and structure in proteins

1 reference

12 December 2020

Autolysis of thermolysin. Isolation and characterization of a folded three-fragment complex

1 reference

12 December 2020

Low-temperature unfolding of a mutant of phage T4 lysozyme. 2. Kinetic investigations.

1 reference

12 December 2020

Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect

1 reference

12 December 2020

Mutational effects on protein stability

1 reference

12 December 2020

Correlation between sites of limited proteolysis and segmental mobility in thermolysin

1 reference

12 December 2020

Stabilization of Bacillus stearothermophilus neutral protease by introduction of prolines

1 reference

12 December 2020

Assessment of protein models with three-dimensional profiles

1 reference

12 December 2020

Effects of changing the interaction between subdomains on the thermostability of Bacillus neutral proteases

1 reference

12 December 2020

Contribution of the C-terminal amino acid to the stability of Bacillus subtilis neutral protease

1 reference

12 December 2020

Protein stability and electrostatic interactions between solvent exposed charged side chains

1 reference

12 December 2020

Energetics of protein structure and folding

1 reference

12 December 2020

Stability of proteins: small globular proteins

1 reference

12 December 2020

Unfolding rates of globular proteins determined by kinetics of proteolysis

1 reference

12 December 2020

Enhanced protein thermostability from site-directed mutations that decrease the entropy of unfolding

1 reference

12 December 2020

Identification of autodigestion target sites in Bacillus subtilis neutral proteinase

1 reference

12 December 2020

Stabilization of phage T4 lysozyme by engineered disulfide bonds

1 reference

12 December 2020

Nucleotide sequence and promoter region for the neutral protease gene from Bacillus stearothermophilus

1 reference

12 December 2020

Introduction of a stabilizing 10 residue beta-hairpin in Bacillus subtilis neutral protease

1 reference

12 December 2020

Rebuilding flavodoxin from C alpha coordinates: a test study.

1 reference

12 December 2020

Is protein turnover thermodynamically controlled?

1 reference

12 December 2020

Dominant forces in protein folding

1 reference

12 December 2020

Role of bound calcium ions in thermostable, proteolytic enzymes. II. Thermolysin, the thermostable protease from Bacillus thermoproteolyticus

1 reference

12 December 2020

Genetic analysis of protein stability and function

1 reference

12 December 2020

Structures of two thermolysin-inhibitor complexes that differ by a single hydrogen bond

1 reference

12 December 2020

Database of homology-derived protein structures and the structural meaning of sequence alignment

1 reference

12 December 2020

The Protein Data Bank: a computer-based archival file for macromolecular structures

1 reference

12 December 2020

Construction of side-chains in homology modelling. Application to the C-terminal lobe of rhizopuspepsin

1 reference

12 December 2020

The structure of thermolysin: An electron density map at 2.3 Å resolution

1 reference

12 December 2020

Calculation of protein conformation as an assembly of stable overlapping segments: application to bovine pancreatic trypsin inhibitor

1 reference

12 December 2020

Effect of Glu-143 and His-231 substitutions on the catalytic activity and secretion of Bacillus subtilis neutral protease

1 reference

12 December 2020

Energetics of repacking a protein interior

1 reference

12 December 2020

The folding of an enzyme. III. Structure of the transition state for unfolding of barnase analysed by a protein engineering procedure

1 reference

12 December 2020

Additivity of mutational effects in proteins

1 reference

12 December 2020

Cloning of the neutral protease gene of Bacillus subtilis and the use of the cloned gene to create an in vitro-derived deletion mutation.

1 reference

12 December 2020

Stabilization of lambda repressor against thermal denaturation by site-directed Gly----Ala changes in alpha-helix 3.

1 reference

12 December 2020

Large increases in general stability for subtilisin BPN' through incremental changes in the free energy of unfolding

1 reference

12 December 2020

Helix movements and the reconstruction of the haem pocket during the evolution of the cytochrome c family

1 reference

12 December 2020

Dissection of helix capping in T4 lysozyme by structural and thermodynamic analysis of six amino acid substitutions at Thr 59.

1 reference

12 December 2020

A new approach to protein fold recognition

1 reference

12 December 2020

Folding of thermolysin fragments. Identification of the minimum size of a carboxyl-terminal fragment that can fold into a stable native-like structure

1 reference

12 December 2020

A relational database of protein structures designed for flexible enquiries about conformation

1 reference

12 December 2020

SESAM: a relational database for structure and sequence of macromolecules.

1 reference

12 December 2020

Protein stability curves

1 reference

12 December 2020

Role of conserved proline residues in stabilizing tryptophan synthase alpha subunit: analysis by mutants with alanine or glycine.

1 reference

12 December 2020

Identification of protein sequence homology by consensus template alignment

1 reference

12 December 2020

Reversible denaturation of the gene V protein of bacteriophage f1.

1 reference

12 December 2020

Analysis of the relationship between side-chain conformation and secondary structure in globular proteins

1 reference

12 December 2020

Histidine residues at the N- and C-termini of alpha-helices: perturbed pKas and protein stability

1 reference

12 December 2020

Active site directed irreversible inhibition of thermolysin

1 reference

12 December 2020

A very fast program for visualizing protein surfaces, channels and cavities.

1 reference

12 December 2020

The role of computer simulation techniques in protein engineering

1 reference

12 December 2020

Substantial increase of protein stability by multiple disulphide bonds

1 reference

12 December 2020

How different amino acid sequences determine similar protein structures: the structure and evolutionary dynamics of the globins

1 reference

12 December 2020

A Method to Identify Protein Sequences That Fold into a Known Three-Dimensional Structure

1 reference

12 December 2020

An interactive computer graphics study of thermolysin-catalyzed peptide cleavage and inhibition by N-carboxymethyl dipeptides

1 reference

12 December 2020

Folding of chymotrypsin inhibitor 2. 2. Influence of proline isomerization on the folding kinetics and thermodynamic characterization of the transition state of folding

1 reference

12 December 2020

The alpha-helix as an electric macro-dipole

1 reference

12 December 2020

On the multiple-minima problem in the conformational analysis of polypeptides. IV. Application of the electrostatically driven Monte Carlo method to the 20-residue membrane-bound portion of melittin

1 reference

12 December 2020

Role of Calcium in the thermal stability of thermolysin

1 reference

12 December 2020

Surface electrostatic interactions contribute little of stability of barnase

1 reference

12 December 2020

An algorithm for determining the conformation of polypeptide segments in proteins by systematic search

1 reference

12 December 2020

In vivo formation and stability of engineered disulfide bonds in subtilisin.

1 reference

12 December 2020

Contributions of hydrogen bonds of Thr 157 to the thermodynamic stability of phage T4 lysozyme

1 reference

12 December 2020

Three-dimensional structure of thermolysin

1 reference

12 December 2020

The engineering of binding affinity at metal ion binding sites for the stabilization of proteins: subtilisin as a test case

1 reference

12 December 2020

A new way of enhancing the thermostability of proteases

1 reference

12 December 2020

Crystallographic structural analysis of phosphoramidates as inhibitors and transition-state analogs of thermolysin

1 reference

12 December 2020

Thermal denaturation of bacteriophage T4 lysozyme at neutral pH.

1 reference

12 December 2020

SIRIUS. An automated method for the analysis of the preferred packing arrangements between protein groups.

1 reference

12 December 2020

Helix stabilization by Glu-...Lys+ salt bridges in short peptides of de novo design

1 reference

12 December 2020

Parameter relation rows: a query system for protein structure function relationships

1 reference

12 December 2020

Structural features of neutral protease from Bacillus subtilis deduced from model-building and limited proteolysis experiments.

1 reference

12 December 2020

Proteases of enhanced stability: characterization of a thermostable variant of subtilisin

1 reference

12 December 2020

A new method for building protein conformations from sequence alignments with homologues of known structure

1 reference

12 December 2020

Cumulative stabilizing effects of glycine to alanine substitutions in Bacillus subtilis neutral protease

1 reference

12 December 2020

1 reference

12 December 2020

A highly thermostable neutral protease from Bacillus caldolyticus: cloning and expression of the gene in Bacillus subtilis and characterization of the gene product

1 reference

12 December 2020

Stabilization of the neutral protease of Bacillus stearothermophilus by removal of a buried water molecule

1 reference

12 December 2020

Entropic stabilization of a mutant human lysozyme induced by calcium binding

1 reference

12 December 2020

Stereochemical basis of heat stability in bacterial ferredoxins and in haemoglobin A2

1 reference

12 December 2020

Effect of single amino acid replacements on the folding and stability of dihydrofolate reductase from Escherichia coli

1 reference

12 December 2020

The Structural and Functional Roles of Metal Ions in Thermolysin

1 reference

12 December 2020

The structure of neutral protease from Bacillus cereus at 0.2-nm resolution.

1 reference

12 December 2020

Hydrophobic stabilization in T4 lysozyme determined directly by multiple substitutions of Ile 3

1 reference

12 December 2020

Effect of single amino acid substitutions on the protease susceptibility of tryptophan synthase alpha subunit

1 reference

12 December 2020

Accurate modeling of protein conformation by automatic segment matching

1 reference

12 December 2020

Thermodynamics of alpha-lactalbumin unfolding

1 reference

12 December 2020

Grafting of a calcium-binding loop of thermolysin to Bacillus subtilis neutral protease

1 reference

12 December 2020

Estimating the contribution of engineered surface electrostatic interactions to protein stability by using double-mutant cycles

1 reference

12 December 2020

Determination and analysis of urea and guanidine hydrochloride denaturation curves

1 reference

12 December 2020

Can the stability of protein mutants be predicted by free energy calculations?

1 reference

12 December 2020

Improving the thermostability of the neutral protease of Bacillus stearothermophilus by replacing a buried asparagine by leucine

1 reference

12 December 2020

Dipoles localized at helix termini of proteins stabilize charges

1 reference

12 December 2020

Arginine residues as stabilizing elements in proteins

1 reference

12 December 2020

Domain unfolding and the stability of thermolysin in guanidine hydrochloride.

1 reference

12 December 2020

Identifiers

DOI

10.1007/BF02337558

1 reference

23 September 2017

journals/jcamd/VriendE93

1 reference

DBLP Dataset 2021-01-02

Dimensions Publication ID

28 January 2021

0 references

1 reference

PubMed ID

8229092