(Q40781981)

23 September 2017

title

Approaches to higher-throughput pharmacokinetics (HTPK) in drug discovery (English)

1 reference

23 September 2017

1 reference

1 reference

Watt AP

1

1 reference

23 September 2017

Morrison I I

series ordinal

2

1 reference

23 September 2017

Evans DC

series ordinal

3

1 reference

23 September 2017

publication date

1 January 2000

1 reference

23 September 2017

1 reference

23 September 2017

volume

5

1 reference

23 September 2017

issue

1

1 reference

23 September 2017

page(s)

17-24

1 reference

Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985)

23 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

New technologies for high-throughput screening

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

Preclinical drug metabolism in the age of high-throughput screening: an industrial perspective

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

High-throughput approaches for evaluating absorption, distribution, metabolism and excretion properties of lead compounds

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

Determination of L-365,260, a new cholecystokinin receptor (CCK-B) antagonist, in plasma by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

Determination of L-654,066, a new 5 alpha-reductase inhibitor in plasma by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

Liquid chromatographic analysis of doxazosin in human serum with manual and robotic sample preparation.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

Sample preparation for LC/MS/MS: analyzing biological and environmental samples

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

Straightforward solid-phase extraction method for the determination of verapamil and its metabolite in plasma in a 96-well extraction plate

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

Automated 96-well solid phase extraction for the determination of doramectin in cattle plasma.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

Use of reduced sorbent bed and disk membrane solid-phase extraction for the analysis of pharmaceutical compounds in biological fluids, with applications in the 96-well format

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

High throughput liquid chromatography/mass spectrometry bioanalysis using 96-well disk solid phase extraction plate for the sample preparation.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

On-line solid-phase extraction with automated cartridge exchange for liquid chromatographic determination of lipophilic antioxidants in plasma

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

Automatic solid-phase extraction and high-performance liquid chromatographic determination of quinidine in plasma

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

Determination of Pranlukast and its metabolites in human plasma by LC/MS/MS with PROSPEKT on-line solid-phase extraction

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

A direct technique for the simultaneous determination of 10 drug candidates in plasma by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry interfaced to a Prospekt solid-phase extraction system

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

The use of turbulent flow chromatography/mass spectrometry for the rapid, direct analysis of a novel pharmaceutical compound in plasma

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

Optimisation and routine use of generic ultra-high flow-rate liquid chromatography with mass spectrometric detection for the direct on-line analysis of pharmaceuticals in plasma

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

Liquid-liquid extraction in the 96-well plate format with SRM LC/MS quantitative determination of methotrexate and its major metabolite in human plasma

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

Automated sample preparation for the determination of budesonide in plasma samples by liquid chromatography and tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

Novel procedure for rapid pharmacokinetic screening of discovery compounds in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

In vivo pharmacokinetic screening in cassette dosing experiments; the use of on-line Pprospekt liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry technology in drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

Effect of the sample matrix on the determination of indinavir in human urine by HPLC with turbo ion spray tandem mass spectrometric detection

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

Quantitation of SR 27417 in human plasma using electrospray liquid chromatography-tandem mass spectrometry: A study of ion suppression

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

Matrix effect in quantitative LC/MS/MS analyses of biological fluids: a method for determination of finasteride in human plasma at picogram per milliliter concentrations

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

Signal enhancement for gradient reverse-phase high-performance liquid chromatography-electrospray ionization mass spectrometry analysis with trifluoroacetic and other strong acid modifiers by postcolumn addition of propionic acid and isopropanol

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

Development of high-performance liquid chromatography-tandem mass spectrometric methods for the determination of a new oxytocin receptor antagonist (L-368,899) extracted from human plasma and urine: a case of lack of specificity due to the presence

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

Investigation of the quantitative properties of the quadrupole orthogonal acceleration time-of-flight mass spectrometer with electrospray ionisation using 3,4-methylenedioxymethamphetamine

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

High throughput liquid chromatography/mass spectrometric analyses using a novel multiplexed electrospray interface

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2899%2901434-8

7 January 2021

10.1016/S1359-6446(99)01434-8

Identifiers

DOI

1 reference

23 September 2017

1 reference