(Q40785972)

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Effect of chemopreventive agents on DNA adduction induced by the potent mammary carcinogen dibenzo[a,l]pyrene in the human breast cells MCF-7.

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scholarly article

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Europe PubMed Central

23 September 2017

Effect of chemopreventive agents on DNA adduction induced by the potent mammary carcinogen dibenzo[a,l]pyrene in the human breast cells MCF-7. (English)

1 reference

Europe PubMed Central

23 September 2017

author name string

W A Smith

1

1 reference

Europe PubMed Central

23 September 2017

J W Freeman

2

1 reference

Europe PubMed Central

23 September 2017

R C Gupta

3

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Europe PubMed Central

23 September 2017

language of work or name

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publication date

1 September 2001

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Europe PubMed Central

23 September 2017

Mutation Research

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Europe PubMed Central

23 September 2017

480-481

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Europe PubMed Central

23 September 2017

97-108

1 reference

Europe PubMed Central

23 September 2017

Cancer chemoprevention: principles and prospects.

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Use of azoxymethane-induced foci of aberrant crypts in rat colon to identify potential cancer chemopreventive agents.

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Use of a microsome-mediated test system to assess efficacy and mechanisms of cancer chemopreventive agents.

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Determining efficacy of cancer chemopreventive agents using a cell-free system concomitant with DNA adduction

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7 January 2021

Effect of cancer chemopreventive agents on microsome-mediated DNA adduction of the breast carcinogen dibenzo[a,l]pyrene

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7 January 2021

Genetic and molecular aspects of 2,3,7,8-tetrachlorodibenzo-p-dioxin action

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Cytochromes P450 5: induction of cytochrome P4501A1: a model for analyzing mammalian gene transcription.

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Co-expression of human CYP1A1 and a human analog of cytochrome P450-EF in response to 2,3,7,8-tetrachloro-dibenzo-p-dioxin in the human mammary carcinoma-derived MCF-7 cells

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7 January 2021

Stable expression of human cytochrome P450 1B1 in V79 Chinese hamster cells and metabolically catalyzed DNA adduct formation of dibenzo[a,l]pyrene

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Tissue-specific expression of the mouse dioxin-inducible P(1)450 and P(3)450 genes: differential transcriptional activation and mRNA stability in liver and extrahepatic tissues

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cDNA cloning, sequence analysis, and induction by aryl hydrocarbons of a murine cytochrome P450 gene, Cyp1b1.

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Differential expression of CYP1A1 and CYP1B1 in human breast epithelial cells and breast tumor cells

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7 January 2021

Comparative dose-response tumorigenicity studies of dibenzo[alpha,l]pyrene versus 7,12-dimethylbenz[alpha]anthracene, benzo[alpha]pyrene and two dibenzo[alpha,l]pyrene dihydrodiols in mouse skin and rat mammary gland

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Tumor-initiating activity and carcinogenicity of dibenzo[a,l]pyrene versus 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene at low doses in mouse skin.

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Exceptional tumor-initiating activity of 4-fluorobenzo[j]-fluoranthene on mouse skin: comparison with benzo[j]-fluoranthene, 10-fluoro-benzo[j]fluoranthene, benzo[a]pyrene, dibenzo[a,l]pyrene and 7,12-dimethylbenz[a]anthracene

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Tumor-initiating activity in mouse skin and carcinogenicity in rat mammary gland of dibenzo[a]pyrenes: the very potent environmental carcinogen dibenzo[a, l]pyrene

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Indoor air sampling and mutagenicity studies of emissions from unvented coal combustion

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Metabolic activation of the potent carcinogen dibenzo[a,l]pyrene by human recombinant cytochromes P450, lung and liver microsomes

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7 January 2021

Identification and quantitation of dibenzo[a,l]pyrene--DNA adducts formed by rat liver microsomes in vitro: preponderance of depurinating adducts

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7 January 2021

Synthesis and mutagenicity of the diastereomeric fjord-region 11,12-dihydrodiol 13,14-epoxides of dibenzo[a,l]pyrene.

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Metabolic activation of the (+)-S,S- and (-)-R,R-enantiomers of trans-11,12-dihydroxy-11,12-dihydrodibenzo[a,l]pyrene: stereoselectivity, DNA adduct formation, and mutagenicity in Chinese hamster V79 cells.

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7 January 2021

Mammary carcinogenicity in female CD rats of fjord region diol epoxides of benzo[c]phenanthrene, benzo[g]chrysene and dibenzo[a,l]pyrene.

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Synthesis and tumor-initiating activity in mouse skin of dibenzo[a,l]pyrene syn- and anti-fjord-region diolepoxides

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Microsome-mediated bioactivation of dibenzo[a,l]pyrene and identification of DNA adducts by 32P-postlabeling.

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Tissue distribution of DNA adducts in rats treated by intramammillary injection with dibenzo[a,l]pyrene, 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene

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Stereoselective activation of dibenzo[a,l]pyrene to (-)-anti (11R,12S,13S,14R)- and (+)-syn(11S,12R,13S,14R)-11,12-diol-13,14-epoxides which bind extensively to deoxyadenosine residues of DNA in the human mammary carcinoma cell line MCF-7.

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Non-specific inhibition of cytochrome P450 activities by chlorophyllin in human and rat liver microsomes.

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Mechanisms of the in vitro antimutagenic action of chlorophyllin against benzo[a]pyrene: studies of enzyme inhibition, molecular complex formation and degradation of the ultimate carcinogen.

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Effects of administration of the chemoprotective agent oltipraz on CYP1A and CYP2B in rat liver and rat hepatocytes in culture

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Chemopreventive activity of oltipraz.

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Development of cancer chemopreventive agents: oltipraz as a paradigm

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Potent inhibition of aflatoxin-induced hepatic tumorigenesis by the monofunctional enzyme inducer 1,2-dithiole-3-thione

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Inhibition of cigarette smoke-related lipophilic DNA adducts in rat tissues by dietary oltipraz

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Clinical pharmacology studies of oltipraz--a potential chemopreventive agent

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Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People's Republic of China

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Regulation of phase 2 enzyme induction by oltipraz and other dithiolethiones

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Identification of dithiolethiones with better chemopreventive properties than oltipraz

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Identifiers

10.1016/S0027-5107(01)00173-7

1 reference

Europe PubMed Central

23 September 2017

1 reference

Europe PubMed Central

23 September 2017

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