(Q40796687)

English

p21 Waf1/Cip1 can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents

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scholarly article

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Europe PubMed Central

23 September 2017

p21 Waf1/Cip1 can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents (English)

1 reference

Europe PubMed Central

23 September 2017

apoptotic process

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colon carcinoma

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based on heuristic

inferred from title

author name string

M Mahyar-Roemer

1

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Europe PubMed Central

23 September 2017

K Roemer

2

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Europe PubMed Central

23 September 2017

language of work or name

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publication date

1 June 2001

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Europe PubMed Central

23 September 2017

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Europe PubMed Central

23 September 2017

20

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Europe PubMed Central

23 September 2017

3387-3398

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Europe PubMed Central

23 September 2017

26

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Europe PubMed Central

23 September 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1204440

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p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells

1 reference

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Butyrate regulates E-cadherin transcription, isoform expression and intracellular position in colon cancer cells

1 reference

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Induction of the growth inhibitor IGF-binding protein 3 by p53

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

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Disruption of p53 in human cancer cells alters the responses to therapeutic agents

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Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1.

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Short chain fatty acids in the human colon

1 reference

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Protective role of p21(Waf1/Cip1) against prostaglandin A2-mediated apoptosis of human colorectal carcinoma cells

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Mitochondria and apoptosis

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Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD.

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Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway

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Thrombin inhibits tumor cell growth in association with up-regulation of p21(waf/cip1) and caspases via a p53-independent, STAT-1-dependent pathway

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Allosteric activation of latent p53 tetramers

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p53 regulation by post-translational modification and nuclear retention in response to diverse stresses

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A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

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Mitochondrial control of cell death

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p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2.

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Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis

1 reference

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Mitochondrial proliferation and paradoxical membrane depolarization during terminal differentiation and apoptosis in a human colon carcinoma cell line

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Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

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Apoptotic death in adenocarcinoma cell lines induced by butyrate and other histone deacetylase inhibitors

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Butyrate production from dietary fibre and protection against large bowel cancer in a rat model

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A novel form of Epstein-Barr virus latency in normal B cells in vivo

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Endogenous endothelial cell nitric-oxide synthase modulates apoptosis in cultured breast cancer cells and is transcriptionally regulated by p53

1 reference

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Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line

1 reference

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21 January 2018

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

1 reference

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p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

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21 January 2018

Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression

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Genetic determinants of p53-induced apoptosis and growth arrest

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A model for p53-induced apoptosis

1 reference

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Changes of mitochondrial mass in the hemopoietic stem cell line FDCP-mix after treatment with etoposide: a correlative study by multiparameter flow cytometry and confocal and electron microscopy.

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The role of mucin in colon-cancer metastasis

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Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1.

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Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria

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Induced p21waf expression in H1299 cell line promotes cell senescence and protects against cytotoxic effect of radiation and doxorubicin

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An information-intensive approach to the molecular pharmacology of cancer.

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KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

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Involvement of p85 in p53-dependent apoptotic response to oxidative stress

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Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

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Function, oligomerization, and conformation of tumor-associated p53 proteins with mutated C-terminus

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Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy

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Early features of zidovudine-associated myopathy: histopathological findings and clinical correlations

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Cells lacking CIP1/WAF1 genes exhibit preferential sensitivity to cisplatin and nitrogen mustard

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p53 status and the efficacy of cancer therapy in vivo

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

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Cell-cycle arrest versus cell death in cancer therapy

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Differentiation-promoting effect of 1-O (2 methoxy) hexadecyl glycerol in human colon cancer cells

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Identifiers

10.1038/SJ.ONC.1204440

1 reference

Europe PubMed Central

23 September 2017

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1 reference

Europe PubMed Central

23 September 2017

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