(Q40802434)

English

The proamphiregulin cytoplasmic domain is required for basolateral sorting, but is not essential for constitutive or stimulus-induced processing in polarized Madin-Darby canine kidney cells

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

The proamphiregulin cytoplasmic domain is required for basolateral sorting, but is not essential for constitutive or stimulus-induced processing in polarized Madin-Darby canine kidney cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

author name string

Brown CL

1

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Coffey RJ

2

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Dempsey PJ

3

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

language of work or name

0 references

publication date

29 May 2001

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

276

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

31

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

29538-29549

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Amphiregulin acts as an autocrine growth factor in two human polarizing colon cancer lines that exhibit domain selective EGF receptor mitogenesis.

1 reference

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Transmembrane TGF-alpha precursors activate EGF/TGF-alpha receptors.

1 reference

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The membrane protein CD9/DRAP 27 potentiates the juxtacrine growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor

1 reference

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Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity

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The tetraspanin CD9 associates with transmembrane TGF-alpha and regulates TGF-alpha-induced EGF receptor activation and cell proliferation

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Contact-dependent growth inhibition and apoptosis of epidermal growth factor (EGF) receptor-expressing cells by the membrane-anchored form of heparin-binding EGF-like growth factor

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Ectodomain shedding of epidermal growth factor receptor ligands is required for keratinocyte migration in cutaneous wound healing

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Removal of the membrane-anchoring domain of epidermal growth factor leads to intracrine signaling and disruption of mammary epithelial cell organization

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The carboxyl-terminal valine residues of proTGF alpha are required for its efficient maturation and intracellular routing

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21 January 2018

A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface

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Transmembrane transforming growth factor-alpha tethers to the PDZ domain-containing, Golgi membrane-associated protein p59/GRASP55

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Apical enrichment of human EGF precursor in Madin-Darby canine kidney cells involves preferential basolateral ectodomain cleavage sensitive to a metalloprotease inhibitor

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Association of the transmembrane TGF-alpha precursor with a protein kinase complex

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Release of the neuregulin functional polypeptide requires its cytoplasmic tail.

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Autocrine regulation of keratinocytes: the emerging role of heparin-binding, epidermal growth factor-related growth factors

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Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor

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A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling

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Cell surface ectodomain cleavage of human amphiregulin precursor is sensitive to a metalloprotease inhibitor. Release of a predominant N-glycosylated 43-kDa soluble form

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Tyrosine phosphorylation and proteolysis. Pervanadate-induced, metalloprotease-dependent cleavage of the ErbB-4 receptor and amphiregulin.

1 reference

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21 January 2018

The heparin-binding domain of amphiregulin necessitates the precursor pro-region for growth factor secretion

1 reference

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21 January 2018

Expression of amphiregulin is regulated in cultured human keratinocytes and in developing fetal skin

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21 January 2018

Molecular cloning and expression of an additional epidermal growth factor receptor-related gene

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A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.

1 reference

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21 January 2018

The shedding of membrane-anchored heparin-binding epidermal-like growth factor is regulated by the Raf/mitogen-activated protein kinase cascade and by cell adhesion and spreading

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Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades

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Stimulation of cleavage of membrane proteins by calmodulin inhibitors

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Diphtheria toxin endocytosis and membrane translocation are dependent on the intact membrane-anchored receptor (HB-EGF precursor): studies on the cell-associated receptor cleaved by a metalloprotease in phorbol-ester-treated cells

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LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction

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Membrane traffic in polarized epithelial cells

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A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells

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The cytoplasmic juxtamembrane domain of the epidermal growth factor receptor contains a novel autonomous basolateral sorting determinant

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Mutant keratin expression in transgenic mice causes marked abnormalities resembling a human genetic skin disease

1 reference

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21 January 2018

Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype

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Polarized trafficking of plasma membrane proteins: emerging roles for coats, SNAREs, GTPases and their link to the cytoskeleton

1 reference

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Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors.

1 reference

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EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

1 reference

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Heparin blockade of thrombin-induced smooth muscle cell migration involves inhibition of epidermal growth factor (EGF) receptor transactivation by heparin-binding EGF-like growth factor

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Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype

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Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor

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Matrix metalloproteinase-3 releases active heparin-binding EGF-like growth factor by cleavage at a specific juxtamembrane site

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Activated release of membrane-anchored TGF-alpha in the absence of cytosol

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Biosynthesis and processing by phorbol ester of the cells surface-associated precursor form of heparin-binding EGF-like growth factor.

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Mechanisms controlling the shedding of transmembrane molecules

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A heparin sulfate-regulated human keratinocyte autocrine factor is similar or identical to amphiregulin

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Polarised expression of human intestinal N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase (human meprin) alpha and beta subunits in Madin-Darby canine kidney cells

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Secretion of human meprin from intestinal epithelial cells depends on differential expression of the alpha and beta subunits

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Strain-dependent epithelial defects in mice lacking the EGF receptor

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The TGF-alpha precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction

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Possible role of coexpression of CD9 with membrane-anchored heparin-binding EGF-like growth factor and amphiregulin in cultured human keratinocyte growth

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Calmodulin regulates L-selectin adhesion molecule expression and function through a protease-dependent mechanism

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The release of acetylcholine receptor inducing activity (ARIA) from its transmembrane precursor in transfected fibroblasts

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Extracellular calcium influx stimulates metalloproteinase cleavage and secretion of heparin-binding EGF-like growth factor independently of protein kinase C

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Trafficking and proteolytic release of epidermal growth factor receptor ligands are modulated by their membrane-anchoring domains

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Characterization of a novel amphiregulin-related molecule in 12-O-tetradecanoylphorbol-13-acetate-treated breast cancer cells

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Autocrine regulation of membrane transforming growth factor-alpha cleavage

1 reference

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Overexpression of amphiregulin in the epidermis of transgenic mice induces a psoriasis-like cutaneous phenotype

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An essential role for ectodomain shedding in mammalian development

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The cytoplasmic carboxy-terminal amino acid specifies cleavage of membrane TGF alpha into soluble growth factor

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21 January 2018

Identifiers

10.1074/JBC.M102114200

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

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